OCAD2_HUMAN
ID OCAD2_HUMAN Reviewed; 154 AA.
AC Q56VL3; B4DPE7; Q8N544;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=OCIA domain-containing protein 2;
DE AltName: Full=Ovarian carcinoma immunoreactive antigen-like protein;
GN Name=OCIAD2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Zhang J., Wu M., Mao Y., Xie Y.;
RL Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Kidney;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Uterine endothelium;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-41, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19608861; DOI=10.1126/science.1175371;
RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C.,
RA Olsen J.V., Mann M.;
RT "Lysine acetylation targets protein complexes and co-regulates major
RT cellular functions.";
RL Science 325:834-840(2009).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- SUBCELLULAR LOCATION: Endosome {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q56VL3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q56VL3-2; Sequence=VSP_027626;
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DR EMBL; AY472117; AAS47684.1; -; mRNA.
DR EMBL; AK298305; BAG60559.1; -; mRNA.
DR EMBL; CR749310; CAH18165.1; -; mRNA.
DR EMBL; CH471069; EAW93077.1; -; Genomic_DNA.
DR EMBL; CH471069; EAW93075.1; -; Genomic_DNA.
DR EMBL; BC032808; AAH32808.1; -; mRNA.
DR CCDS; CCDS33981.1; -. [Q56VL3-1]
DR CCDS; CCDS3485.1; -. [Q56VL3-2]
DR RefSeq; NP_001014446.1; NM_001014446.2. [Q56VL3-1]
DR RefSeq; NP_001273702.1; NM_001286773.1. [Q56VL3-2]
DR RefSeq; NP_689611.1; NM_152398.3. [Q56VL3-2]
DR AlphaFoldDB; Q56VL3; -.
DR BioGRID; 126317; 68.
DR IntAct; Q56VL3; 24.
DR MINT; Q56VL3; -.
DR STRING; 9606.ENSP00000423014; -.
DR iPTMnet; Q56VL3; -.
DR PhosphoSitePlus; Q56VL3; -.
DR SwissPalm; Q56VL3; -.
DR BioMuta; OCIAD2; -.
DR DMDM; 74741044; -.
DR EPD; Q56VL3; -.
DR jPOST; Q56VL3; -.
DR MassIVE; Q56VL3; -.
DR MaxQB; Q56VL3; -.
DR PaxDb; Q56VL3; -.
DR PeptideAtlas; Q56VL3; -.
DR PRIDE; Q56VL3; -.
DR ProteomicsDB; 62591; -. [Q56VL3-1]
DR ProteomicsDB; 62592; -. [Q56VL3-2]
DR Antibodypedia; 23867; 167 antibodies from 26 providers.
DR DNASU; 132299; -.
DR Ensembl; ENST00000273860.8; ENSP00000273860.4; ENSG00000145247.12. [Q56VL3-2]
DR Ensembl; ENST00000508632.6; ENSP00000423014.1; ENSG00000145247.12. [Q56VL3-1]
DR Ensembl; ENST00000620187.4; ENSP00000483997.1; ENSG00000145247.12. [Q56VL3-2]
DR GeneID; 132299; -.
DR KEGG; hsa:132299; -.
DR MANE-Select; ENST00000508632.6; ENSP00000423014.1; NM_001014446.3; NP_001014446.1.
DR UCSC; uc003gyt.5; human. [Q56VL3-1]
DR CTD; 132299; -.
DR DisGeNET; 132299; -.
DR GeneCards; OCIAD2; -.
DR HGNC; HGNC:28685; OCIAD2.
DR HPA; ENSG00000145247; Tissue enhanced (kidney).
DR MIM; 619633; gene.
DR neXtProt; NX_Q56VL3; -.
DR OpenTargets; ENSG00000145247; -.
DR PharmGKB; PA128394755; -.
DR VEuPathDB; HostDB:ENSG00000145247; -.
DR eggNOG; ENOG502S4DE; Eukaryota.
DR GeneTree; ENSGT00530000063690; -.
DR HOGENOM; CLU_109198_0_0_1; -.
DR InParanoid; Q56VL3; -.
DR OMA; GGWKCPL; -.
DR OrthoDB; 1322104at2759; -.
DR PhylomeDB; Q56VL3; -.
DR TreeFam; TF327106; -.
DR PathwayCommons; Q56VL3; -.
DR SignaLink; Q56VL3; -.
DR BioGRID-ORCS; 132299; 7 hits in 1048 CRISPR screens.
DR ChiTaRS; OCIAD2; human.
DR GenomeRNAi; 132299; -.
DR Pharos; Q56VL3; Tbio.
DR PRO; PR:Q56VL3; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q56VL3; protein.
DR Bgee; ENSG00000145247; Expressed in kidney epithelium and 177 other tissues.
DR ExpressionAtlas; Q56VL3; baseline and differential.
DR Genevisible; Q56VL3; HS.
DR GO; GO:0005768; C:endosome; ISS:FlyBase.
DR GO; GO:0005794; C:Golgi apparatus; ISS:FlyBase.
DR GO; GO:0005764; C:lysosome; ISS:FlyBase.
DR GO; GO:0006897; P:endocytosis; ISS:FlyBase.
DR GO; GO:0061484; P:hematopoietic stem cell homeostasis; ISS:FlyBase.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; ISS:FlyBase.
DR GO; GO:0009617; P:response to bacterium; IEA:Ensembl.
DR InterPro; IPR040187; OCAD1/2.
DR InterPro; IPR009764; OCIA_dom.
DR PANTHER; PTHR13336; PTHR13336; 1.
DR Pfam; PF07051; OCIA; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Endosome; Reference proteome.
FT CHAIN 1..154
FT /note="OCIA domain-containing protein 2"
FT /id="PRO_0000299392"
FT DOMAIN 1..120
FT /note="OCIA"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 41
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:19608861"
FT VAR_SEQ 89..154
FT /note="LAGLLGFGLGKVSYIGVCQSKFHFFEDQLRGAGFGPQHNRHCLLTCEECKIK
FT HGLSEKGDSQPSAS -> RTASLPVRNAK (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_027626"
FT VARIANT 44
FT /note="R -> Q (in dbSNP:rs7676916)"
FT /id="VAR_053950"
SQ SEQUENCE 154 AA; 16954 MW; B2278F751BA03A3E CRC64;
MASASARGNQ DKDAHFPPPS KQSLLFCPKS KLHIHRAEIS KIMRECQEES FWKRALPFSL
VSMLVTQGLV YQGYLAANSR FGSLPKVALA GLLGFGLGKV SYIGVCQSKF HFFEDQLRGA
GFGPQHNRHC LLTCEECKIK HGLSEKGDSQ PSAS
