ID   OCAD2_MOUSE             Reviewed;         154 AA.
AC   Q9D8W7;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=OCIA domain-containing protein 2;
GN   Name=Ociad2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Pancreas;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, and
RC   Pancreas;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [4]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-41, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=23576753; DOI=10.1073/pnas.1302961110;
RA   Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B.,
RA   Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.;
RT   "Label-free quantitative proteomics of the lysine acetylome in mitochondria
RT   identifies substrates of SIRT3 in metabolic pathways.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013).
CC   -!- SUBCELLULAR LOCATION: Endosome {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK007617; BAB25138.1; -; mRNA.
DR   EMBL; BC044883; AAH44883.1; -; mRNA.
DR   CCDS; CCDS19340.1; -.
DR   RefSeq; NP_081226.1; NM_026950.4.
DR   AlphaFoldDB; Q9D8W7; -.
DR   STRING; 10090.ENSMUSP00000084445; -.
DR   iPTMnet; Q9D8W7; -.
DR   PhosphoSitePlus; Q9D8W7; -.
DR   SwissPalm; Q9D8W7; -.
DR   jPOST; Q9D8W7; -.
DR   MaxQB; Q9D8W7; -.
DR   PaxDb; Q9D8W7; -.
DR   PeptideAtlas; Q9D8W7; -.
DR   PRIDE; Q9D8W7; -.
DR   ProteomicsDB; 294067; -.
DR   Antibodypedia; 23867; 167 antibodies from 26 providers.
DR   DNASU; 433904; -.
DR   Ensembl; ENSMUST00000087195; ENSMUSP00000084445; ENSMUSG00000029153.
DR   GeneID; 433904; -.
DR   KEGG; mmu:433904; -.
DR   UCSC; uc008xsw.1; mouse.
DR   CTD; 132299; -.
DR   MGI; MGI:1916377; Ociad2.
DR   VEuPathDB; HostDB:ENSMUSG00000029153; -.
DR   eggNOG; ENOG502S4DE; Eukaryota.
DR   GeneTree; ENSGT00530000063690; -.
DR   HOGENOM; CLU_109198_0_0_1; -.
DR   InParanoid; Q9D8W7; -.
DR   OMA; GGWKCPL; -.
DR   OrthoDB; 1322104at2759; -.
DR   PhylomeDB; Q9D8W7; -.
DR   TreeFam; TF327106; -.
DR   BioGRID-ORCS; 433904; 3 hits in 73 CRISPR screens.
DR   ChiTaRS; Ociad2; mouse.
DR   PRO; PR:Q9D8W7; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; Q9D8W7; protein.
DR   Bgee; ENSMUSG00000029153; Expressed in ciliary body and 217 other tissues.
DR   ExpressionAtlas; Q9D8W7; baseline and differential.
DR   Genevisible; Q9D8W7; MM.
DR   GO; GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005743; C:mitochondrial inner membrane; HDA:MGI.
DR   GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR   GO; GO:0009617; P:response to bacterium; IEP:MGI.
DR   InterPro; IPR040187; OCAD1/2.
DR   InterPro; IPR009764; OCIA_dom.
DR   PANTHER; PTHR13336; PTHR13336; 1.
DR   Pfam; PF07051; OCIA; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Endosome; Reference proteome.
FT   CHAIN           1..154
FT                   /note="OCIA domain-containing protein 2"
FT                   /id="PRO_0000299393"
FT   DOMAIN          1..120
FT                   /note="OCIA"
FT   MOD_RES         41
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0007744|PubMed:23576753"
SQ   SEQUENCE   154 AA;  16926 MW;  CBA0DB1590C1ED04 CRC64;
     MASVSTHGNQ EKSPHLPPLS KQSLLFCPKS KLHIHRGEIA KIIRECQEES FWKRALPFSL
     ISMLVTQGLV HQGYLAANPR FGSLPKVALA GLLGFGLGKA SYIRVCQSKF HSFEDQLRGA
     GFGPEHNRHC LLTCEDCKTR RGLSEKAGSQ PSAS