ID   OCC1_HUMAN              Reviewed;          63 AA.
AC   Q8TAD7;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-APR-2009, sequence version 2.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Overexpressed in colon carcinoma 1 protein;
DE            Short=OCC-1;
DE   AltName: Full=AGD3;
GN   Name=OCC1; Synonyms=C12orf75;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Kidney;
RX   PubMed=11890990; DOI=10.1016/s0165-4608(01)00634-3;
RA   Pibouin L., Villaudy J., Ferbus D., Muleris M., Prosperi M.T., Remvikos Y.,
RA   Goubin G.;
RT   "Cloning of the mRNA of overexpression in colon carcinoma-1: a sequence
RT   overexpressed in a subset of colon carcinomas.";
RL   Cancer Genet. Cytogenet. 133:55-60(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA   Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA   Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA   Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA   Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA   Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA   Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA   Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA   Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA   Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA   Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA   Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA   Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA   David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA   D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA   Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA   Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA   Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA   LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA   Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA   Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA   Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA   Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA   Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA   Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA   Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA   Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA   Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA   Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA   Gibbs R.A.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Bone marrow, Liver, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   TISSUE SPECIFICITY.
RX   PubMed=19531736; DOI=10.1093/nar/gkp426;
RA   Kikuchi K., Fukuda M., Ito T., Inoue M., Yokoi T., Chiku S., Mitsuyama T.,
RA   Asai K., Hirose T., Aizawa Y.;
RT   "Transcripts of unknown function in multiple-signaling pathways involved in
RT   human stem cell differentiation.";
RL   Nucleic Acids Res. 37:4987-5000(2009).
CC   -!- TISSUE SPECIFICITY: High expression in placenta, skeletal muscle,
CC       kidney and pancreas tissues. Absent or very faint expression in heart,
CC       brain, lung and liver. Expressed during adipogenic differentiation of
CC       mesenchymal stem cells (at protein level).
CC       {ECO:0000269|PubMed:11890990, ECO:0000269|PubMed:19531736}.
CC   -!- SIMILARITY: Belongs to the OCC1 family. {ECO:0000305}.
CC   -!- CAUTION: Was reported to be transcribed but not translated
CC       (PubMed:11890990). However, it was later shown that it is expressed at
CC       protein level (PubMed:19531736). {ECO:0000305|PubMed:11890990,
CC       ECO:0000305|PubMed:19531736}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH13920.2; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
CC       Sequence=AAH45812.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
CC       Sequence=AAH61920.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
CC       Sequence=AAH67897.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
CC       Sequence=CAC85391.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
CC       Sequence=CAC85392.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
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DR   EMBL; AJ311378; CAC85391.1; ALT_SEQ; mRNA.
DR   EMBL; AJ311377; CAC85392.1; ALT_SEQ; mRNA.
DR   EMBL; AK056999; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AC011313; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC013920; AAH13920.2; ALT_SEQ; mRNA.
DR   EMBL; BC045812; AAH45812.1; ALT_SEQ; mRNA.
DR   EMBL; BC061920; AAH61920.1; ALT_SEQ; mRNA.
DR   EMBL; BC067897; AAH67897.1; ALT_SEQ; mRNA.
DR   CCDS; CCDS55879.1; -.
DR   RefSeq; NP_001138671.1; NM_001145199.1.
DR   AlphaFoldDB; Q8TAD7; -.
DR   BioGRID; 132482; 35.
DR   IntAct; Q8TAD7; 9.
DR   STRING; 9606.ENSP00000448536; -.
DR   iPTMnet; Q8TAD7; -.
DR   PhosphoSitePlus; Q8TAD7; -.
DR   SwissPalm; Q8TAD7; -.
DR   BioMuta; C12orf75; -.
DR   EPD; Q8TAD7; -.
DR   jPOST; Q8TAD7; -.
DR   MassIVE; Q8TAD7; -.
DR   MaxQB; Q8TAD7; -.
DR   PaxDb; Q8TAD7; -.
DR   PeptideAtlas; Q8TAD7; -.
DR   PRIDE; Q8TAD7; -.
DR   TopDownProteomics; Q8TAD7; -.
DR   Antibodypedia; 54774; 116 antibodies from 22 providers.
DR   DNASU; 387882; -.
DR   Ensembl; ENST00000443585.6; ENSP00000448536.2; ENSG00000235162.9.
DR   GeneID; 387882; -.
DR   KEGG; hsa:387882; -.
DR   MANE-Select; ENST00000443585.6; ENSP00000448536.2; NM_001145199.2; NP_001138671.1.
DR   UCSC; uc001tlh.4; human.
DR   CTD; 387882; -.
DR   DisGeNET; 387882; -.
DR   GeneCards; C12orf75; -.
DR   HGNC; HGNC:35164; C12orf75.
DR   HPA; ENSG00000235162; Tissue enhanced (seminal).
DR   neXtProt; NX_Q8TAD7; -.
DR   OpenTargets; ENSG00000235162; -.
DR   PharmGKB; PA164716815; -.
DR   VEuPathDB; HostDB:ENSG00000235162; -.
DR   eggNOG; ENOG502SSZ4; Eukaryota.
DR   GeneTree; ENSGT00610000087444; -.
DR   InParanoid; Q8TAD7; -.
DR   OMA; MTQERAC; -.
DR   OrthoDB; 1633686at2759; -.
DR   PhylomeDB; Q8TAD7; -.
DR   PathwayCommons; Q8TAD7; -.
DR   SignaLink; Q8TAD7; -.
DR   BioGRID-ORCS; 387882; 107 hits in 1048 CRISPR screens.
DR   ChiTaRS; C12orf75; human.
DR   GenomeRNAi; 387882; -.
DR   Pharos; Q8TAD7; Tbio.
DR   PRO; PR:Q8TAD7; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q8TAD7; protein.
DR   Bgee; ENSG00000235162; Expressed in skeletal muscle tissue of rectus abdominis and 168 other tissues.
DR   ExpressionAtlas; Q8TAD7; baseline and differential.
DR   Genevisible; Q8TAD7; HS.
DR   InterPro; IPR029133; OCC1.
DR   PANTHER; PTHR38502; PTHR38502; 1.
DR   Pfam; PF15506; OCC1; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..63
FT                   /note="Overexpressed in colon carcinoma 1 protein"
FT                   /id="PRO_0000368221"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   63 AA;  6407 MW;  60F992759DB5FCCD CRC64;
     MGCGNSTATS AGAGQGPAGA AKDVTEESVT EDDKRRNYGG VYVGLPSEAV NMVSSQTKTV
     RKN