ID   OCCR_AGRT4              Reviewed;         298 AA.
AC   P0A4T4; P81526; Q00679;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Octopine catabolism/uptake operon regulatory protein OccR;
GN   Name=occR;
OS   Agrobacterium tumefaciens (strain Ach5).
OG   Plasmid pTiAch5.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium;
OC   Agrobacterium tumefaciens complex.
OX   NCBI_TaxID=176298;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1799698; DOI=10.1094/mpmi-4-370;
RA   von Lintig J., Zanker H., Schroeder J.;
RT   "Positive regulators of opine-inducible promoters in the nopaline and
RT   octopine catabolism regions of Ti plasmids.";
RL   Mol. Plant Microbe Interact. 4:370-378(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Schroeder J., von Lintig J., Zanker H.;
RT   "Catabolism of the guanidino compounds nopaline, octopine, and L-arginine
RT   in Agrobacterium tumefaciens: enzymes, genes, and regulation.";
RL   (In) De Deyn P.P., Marescau B., Stalon V., Qureshi I.A. (eds.);
RL   Guanidino compounds in biology and medicine, pp.19-28, J. Libbey, London
RL   (1992).
CC   -!- FUNCTION: Positive regulatory protein for the occ operon involved in
CC       octopine catabolism and uptake. Also acts as a negative regulator of
CC       its expression.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; M65108; AAA50520.1; -; Genomic_DNA.
DR   EMBL; Z30328; CAA82982.1; -; Genomic_DNA.
DR   PIR; S28672; S28672.
DR   RefSeq; NP_059715.1; NC_002377.1.
DR   PDB; 5VVI; X-ray; 2.28 A; A/B/C=92-298.
DR   PDBsum; 5VVI; -.
DR   AlphaFoldDB; P0A4T4; -.
DR   SMR; P0A4T4; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd08457; PBP2_OccR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR037415; OccR_PBP2.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Activator; DNA-binding; Plasmid; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..298
FT                   /note="Octopine catabolism/uptake operon regulatory protein
FT                   OccR"
FT                   /id="PRO_0000105697"
FT   DOMAIN          1..58
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        18..37
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   STRAND          92..97
FT                   /evidence="ECO:0007829|PDB:5VVI"
FT   HELIX           99..102
FT                   /evidence="ECO:0007829|PDB:5VVI"
FT   HELIX           105..114
FT                   /evidence="ECO:0007829|PDB:5VVI"
FT   STRAND          121..126
FT                   /evidence="ECO:0007829|PDB:5VVI"
FT   HELIX           129..137
FT                   /evidence="ECO:0007829|PDB:5VVI"
FT   STRAND          142..148
FT                   /evidence="ECO:0007829|PDB:5VVI"
FT   STRAND          155..163
FT                   /evidence="ECO:0007829|PDB:5VVI"
FT   STRAND          165..169
FT                   /evidence="ECO:0007829|PDB:5VVI"
FT   HELIX           173..176
FT                   /evidence="ECO:0007829|PDB:5VVI"
FT   HELIX           182..185
FT                   /evidence="ECO:0007829|PDB:5VVI"
FT   STRAND          190..192
FT                   /evidence="ECO:0007829|PDB:5VVI"
FT   HELIX           198..206
FT                   /evidence="ECO:0007829|PDB:5VVI"
FT   TURN            207..209
FT                   /evidence="ECO:0007829|PDB:5VVI"
FT   HELIX           221..229
FT                   /evidence="ECO:0007829|PDB:5VVI"
FT   STRAND          234..237
FT                   /evidence="ECO:0007829|PDB:5VVI"
FT   HELIX           239..242
FT                   /evidence="ECO:0007829|PDB:5VVI"
FT   HELIX           243..245
FT                   /evidence="ECO:0007829|PDB:5VVI"
FT   TURN            246..248
FT                   /evidence="ECO:0007829|PDB:5VVI"
FT   STRAND          249..256
FT                   /evidence="ECO:0007829|PDB:5VVI"
FT   STRAND          259..270
FT                   /evidence="ECO:0007829|PDB:5VVI"
FT   HELIX           274..293
FT                   /evidence="ECO:0007829|PDB:5VVI"
SQ   SEQUENCE   298 AA;  32666 MW;  AC805586D821D64C CRC64;
     MNLRQVEAFR AVMLTGQMTA AAELMLVTQP AISRLIKDFE QATKLQLFER RGNHIIPTQE
     AKTLWKEVDR AFVGLNHIGN LAADIGRQAA GTLRIAAMPA LANGLLPRFL AQFIRDRPNL
     QVSLMGLPSS MVMEAVASGR ADIGYADGPQ ERQGFLIETR SLPAVVAVPM GHRLAGLDRV
     TPQDLAGERI IKQETGTLFA MRVEVAIGGI QRRPSIEVSL SHTALSLVRE GAGIAIIDPA
     AAIEFTDRIV LRPFSIFIDA GFLEVRSAIG APSTIVDRFT TEFWRFHDDL MKQNGLME