ID   OCE1_LEPKN              Reviewed;          25 AA.
AC   P86711;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 1.
DT   25-MAY-2022, entry version 14.
DE   RecName: Full=Ocellatin-K1 {ECO:0000303|Ref.1};
OS   Leptodactylus knudseni (Knudsen's thin-toed frog) (Amazonian toad-frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Leptodactylidae; Leptodactylinae;
OC   Leptodactylus.
OX   NCBI_TaxID=326593;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP   SPECTROMETRY, AND AMIDATION AT ILE-25.
RC   TISSUE=Skin secretion;
RA   Cardozo-Filho J.L., Soares A.A., Bloch C. Jr., Silva L.P., Stabeli R.G.,
RA   Calderon L.A.;
RT   "Identification of peptides from Amazonian Leptodactylus knudseni skin
RT   secretion by MALDI TOF/TOF.";
RL   Submitted (JUL-2010) to UniProtKB.
CC   -!- FUNCTION: Has hemolytic and antibacterial activity.
CC       {ECO:0000250|UniProtKB:P83951}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands. {ECO:0000269|Ref.1}.
CC   -!- MASS SPECTROMETRY: Mass=2548; Mass_error=0.01; Method=MALDI;
CC       Evidence={ECO:0000269|Ref.1};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Ocellatin subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P86711; -.
DR   BMRB; P86711; -.
DR   SMR; P86711; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0019836; P:hemolysis by symbiont of host erythrocytes; IEA:InterPro.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR012518; Antimicrobial15.
DR   Pfam; PF08110; Antimicrobial15; 1.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Antibiotic; Antimicrobial; Cytolysis;
KW   Direct protein sequencing; Hemolysis; Secreted.
FT   PEPTIDE         1..25
FT                   /note="Ocellatin-K1"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="PRO_0000398811"
FT   MOD_RES         25
FT                   /note="Isoleucine amide"
FT                   /evidence="ECO:0000269|Ref.1"
SQ   SEQUENCE   25 AA;  2549 MW;  3B32EAC8DA060755 CRC64;
     GVVDILKGAA KDLAGHLASK VMNKI