OCE3_LEPOE
ID OCE3_LEPOE Reviewed; 21 AA.
AC P83867;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 1.
DT 25-MAY-2022, entry version 46.
DE RecName: Full=Ocellatin-3;
OS Leptodactylus ocellatus (Argus frog) (Leptodactylus macrosternum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Hyloidea; Leptodactylidae; Leptodactylinae;
OC Leptodactylus.
OX NCBI_TaxID=928525 {ECO:0000305};
RN [1]
RP PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY, AND AMIDATION AT ILE-21.
RC TISSUE=Skin secretion;
RX PubMed=15648972; DOI=10.1007/s10930-004-7877-z;
RA Nascimento A.C.C., Zanotta L.C., Kyaw C.M., Schwartz E.N.F., Schwartz C.A.,
RA Sebben A., Sousa M.V., Fontes W., Castro M.S.;
RT "Ocellatins: new antimicrobial peptides from the skin secretion of the
RT South American frog Leptodactylus ocellatus (Anura: Leptodactylidae).";
RL Protein J. 23:501-508(2004).
CC -!- FUNCTION: Has hemolytic activity against human erythrocytes and
CC antibacterial activity against the Gram-negative bacterium E.coli.
CC {ECO:0000269|PubMed:15648972, ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the skin dorsal glands.
CC -!- MASS SPECTROMETRY: Mass=2200.89; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:15648972, ECO:0000305};
CC -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC Ocellatin subfamily. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=The antimicrobial peptide database;
CC URL="https://wangapd3.com/database/query_output.php?ID=00545";
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DR AlphaFoldDB; P83867; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0019836; P:hemolysis by symbiont of host erythrocytes; IEA:InterPro.
DR GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR InterPro; IPR012518; Antimicrobial15.
DR Pfam; PF08110; Antimicrobial15; 1.
PE 1: Evidence at protein level;
KW Amidation; Amphibian defense peptide; Antibiotic; Antimicrobial; Cytolysis;
KW Direct protein sequencing; Hemolysis; Secreted.
FT PEPTIDE 1..21
FT /note="Ocellatin-3"
FT /id="PRO_0000043817"
FT MOD_RES 21
FT /note="Isoleucine amide"
FT /evidence="ECO:0000269|PubMed:15648972"
SQ SEQUENCE 21 AA; 2203 MW; 65DA4B2F0B74132E CRC64;
GVLDILKNAA KNILAHAAEQ I