OCEL1_MOUSE
ID OCEL1_MOUSE Reviewed; 219 AA.
AC Q8VCR9; Q3U2L0; Q9CX17;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Occludin/ELL domain-containing protein 1;
GN Name=Ocel1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the ELL/occludin family. {ECO:0000305}.
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DR EMBL; AK020528; BAB32126.1; -; mRNA.
DR EMBL; AK155219; BAE33130.1; -; mRNA.
DR EMBL; BC019407; AAH19407.1; -; mRNA.
DR CCDS; CCDS22391.1; -.
DR RefSeq; NP_084141.2; NM_029865.2.
DR AlphaFoldDB; Q8VCR9; -.
DR SMR; Q8VCR9; -.
DR STRING; 10090.ENSMUSP00000002469; -.
DR PhosphoSitePlus; Q8VCR9; -.
DR PaxDb; Q8VCR9; -.
DR PRIDE; Q8VCR9; -.
DR DNASU; 77090; -.
DR GeneID; 77090; -.
DR KEGG; mmu:77090; -.
DR CTD; 79629; -.
DR MGI; MGI:1924340; Ocel1.
DR eggNOG; KOG4796; Eukaryota.
DR InParanoid; Q8VCR9; -.
DR OrthoDB; 1299186at2759; -.
DR PhylomeDB; Q8VCR9; -.
DR BioGRID-ORCS; 77090; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Ocel1; mouse.
DR PRO; PR:Q8VCR9; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8VCR9; protein.
DR GO; GO:0016324; C:apical plasma membrane; IBA:GO_Central.
DR GO; GO:0005923; C:bicellular tight junction; IBA:GO_Central.
DR GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR GO; GO:0070830; P:bicellular tight junction assembly; IBA:GO_Central.
DR InterPro; IPR031176; ELL/occludin.
DR InterPro; IPR010844; Occludin_ELL.
DR InterPro; IPR031182; Ocel1.
DR PANTHER; PTHR23288; PTHR23288; 1.
DR PANTHER; PTHR23288:SF15; PTHR23288:SF15; 1.
DR Pfam; PF07303; Occludin_ELL; 1.
DR PROSITE; PS51980; OCEL; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..219
FT /note="Occludin/ELL domain-containing protein 1"
FT /id="PRO_0000271532"
FT DOMAIN 100..210
FT /note="OCEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01324"
FT REGION 1..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..94
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 67
FT /note="K -> R (in Ref. 1; BAE33130/BAB32126)"
FT /evidence="ECO:0000305"
FT CONFLICT 172
FT /note="F -> L (in Ref. 1; BAB32126)"
FT /evidence="ECO:0000305"
FT CONFLICT 177
FT /note="V -> G (in Ref. 1; BAE33130/BAB32126)"
FT /evidence="ECO:0000305"
FT CONFLICT 190
FT /note="Y -> C (in Ref. 1; BAE33130)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 219 AA; 25111 MW; EA65E8EB22398A4F CRC64;
MQIHAGPASR RGRRGPLARL SGPEATCNSR PAARGRQRAA APRMPAPERP RSRRPQSQPG
PGELCVKPRK IVFADELRPR EPLHPEKHPR DLGPRLNPVP DYELKYPPVT NRRDRSRYAA
VFQDQYGEFS ELQREVGATQ AKLQQLEALL LSLPPPRSQK EARMAAHVRR EFEKKRVDPG
FLDKQARCNY LKGKLRHLKA QIRKFDDQQD SNSEDSVYF
