ID   ARSC_HALSA              Reviewed;         142 AA.
AC   O52030;
DT   14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Putative arsenate reductase;
DE            EC=1.20.4.-;
GN   Name=arsC; OrderedLocusNames=VNG_5183G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OG   Plasmid pNRC100.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=9847077; DOI=10.1101/gr.8.11.1131;
RA   Ng W.V., Ciufo S.A., Smith T.M., Bumgarner R.E., Baskin D., Faust J.,
RA   Hall B., Loretz C., Seto J., Slagel J., Hood L., DasSarma S.;
RT   "Snapshot of a large dynamic replicon in a halophilic archaeon: megaplasmid
RT   or minichromosome?";
RL   Genome Res. 8:1131-1141(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
RN   [3]
RP   INDUCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=15126481; DOI=10.1128/jb.186.10.3187-3194.2004;
RA   Wang G., Kennedy S.P., Fasiludeen S., Rensing C., DasSarma S.;
RT   "Arsenic resistance in Halobacterium sp. strain NRC-1 examined by using an
RT   improved gene knockout system.";
RL   J. Bacteriol. 186:3187-3194(2004).
CC   -!- FUNCTION: Reduces arsenate [As(V)] to arsenite [As(III)].
CC       {ECO:0000250}.
CC   -!- INDUCTION: Weakly induced by arsenite, antimonite and arsenate.
CC       {ECO:0000269|PubMed:15126481}.
CC   -!- DISRUPTION PHENOTYPE: Deletion of the arsADRC operon results in
CC       increased sensitivity to arsenite and antimonite but not arsenate.
CC       {ECO:0000269|PubMed:15126481}.
CC   -!- MISCELLANEOUS: As expression is low no effect on arsenate resistance
CC       has been found. {ECO:0000305|PubMed:15126481}.
CC   -!- SIMILARITY: Belongs to the low molecular weight phosphotyrosine protein
CC       phosphatase family. {ECO:0000305}.
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DR   EMBL; AF016485; AAC82910.1; -; Genomic_DNA.
DR   PIR; T08343; T08343.
DR   RefSeq; WP_010890456.1; NZ_BK010830.1.
DR   AlphaFoldDB; O52030; -.
DR   SMR; O52030; -.
DR   EnsemblBacteria; AAC82910; AAC82910; AAC82910.
DR   GeneID; 5954919; -.
DR   GeneID; 62888359; -.
DR   KEGG; hal:AAC82910.1; -.
DR   HOGENOM; CLU_071415_3_3_2; -.
DR   OMA; EKIAFVC; -.
DR   OrthoDB; 108917at2157; -.
DR   PhylomeDB; O52030; -.
DR   Proteomes; UP000000554; Plasmid pNRC100.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046685; P:response to arsenic-containing substance; IEA:UniProtKB-KW.
DR   InterPro; IPR023485; Ptyr_pPase.
DR   InterPro; IPR036196; Ptyr_pPase_sf.
DR   Pfam; PF01451; LMWPc; 1.
DR   SMART; SM00226; LMWPc; 1.
DR   SUPFAM; SSF52788; SSF52788; 1.
PE   2: Evidence at transcript level;
KW   Arsenical resistance; Oxidoreductase; Plasmid; Reference proteome.
FT   CHAIN           1..142
FT                   /note="Putative arsenate reductase"
FT                   /id="PRO_0000429116"
SQ   SEQUENCE   142 AA;  16031 MW;  358F4DA011E2D31A CRC64;
     MSADSTTKFG FVCVQNAGRS QMSTAFAERE RERRDLEDSV EILTGGTHPA DHVHEEVVEV
     MGEEGFDLSE RTPREVSTDE LESCDIVATM GCSTLELDAE TVDVRDWALD DPDGQEMEQV
     REIRDDIEQR VVDLFDEFNP DD