OCM2_HUMAN
ID OCM2_HUMAN Reviewed; 109 AA.
AC P0CE71; P32930; Q6ISI5; Q75MW0;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 23-MAR-2010, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Putative oncomodulin-2;
GN Name=OCM2; Synonyms=OCMN;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
CC -!- SIMILARITY: Belongs to the parvalbumin family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AC004967; AAQ96880.1; -; Genomic_DNA.
DR CCDS; CCDS5653.1; -.
DR RefSeq; NP_006179.2; NM_006188.3.
DR AlphaFoldDB; P0CE71; -.
DR BMRB; P0CE71; -.
DR SMR; P0CE71; -.
DR BioGRID; 111005; 10.
DR IntAct; P0CE71; 3.
DR STRING; 9606.ENSP00000257627; -.
DR iPTMnet; P0CE71; -.
DR PhosphoSitePlus; P0CE71; -.
DR BioMuta; OCM2; -.
DR DMDM; 292630842; -.
DR MassIVE; P0CE71; -.
DR PaxDb; P0CE71; -.
DR PRIDE; P0CE71; -.
DR Antibodypedia; 30217; 13 antibodies from 7 providers.
DR DNASU; 4951; -.
DR Ensembl; ENST00000257627.4; ENSP00000257627.4; ENSG00000135175.5.
DR GeneID; 4951; -.
DR KEGG; hsa:4951; -.
DR MANE-Select; ENST00000257627.5; ENSP00000257627.4; NM_006188.4; NP_006179.2.
DR UCSC; uc003upc.4; human.
DR CTD; 4951; -.
DR GeneCards; OCM2; -.
DR HGNC; HGNC:34396; OCM2.
DR HPA; ENSG00000135175; Not detected.
DR neXtProt; NX_P0CE71; -.
DR OpenTargets; ENSG00000135175; -.
DR PharmGKB; PA164724233; -.
DR VEuPathDB; HostDB:ENSG00000135175; -.
DR eggNOG; KOG0027; Eukaryota.
DR GeneTree; ENSGT00940000161875; -.
DR HOGENOM; CLU_157356_0_0_1; -.
DR InParanoid; P0CE71; -.
DR OMA; KKFFQVC; -.
DR OrthoDB; 1524081at2759; -.
DR PhylomeDB; P0CE71; -.
DR TreeFam; TF332342; -.
DR PathwayCommons; P0CE71; -.
DR SignaLink; P0CE71; -.
DR BioGRID-ORCS; 4951; 30 hits in 973 CRISPR screens.
DR GeneWiki; LOC4951; -.
DR GenomeRNAi; 4951; -.
DR Pharos; P0CE71; Tdark.
DR PRO; PR:P0CE71; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; P0CE71; protein.
DR Bgee; ENSG00000135175; Expressed in bone marrow and 26 other tissues.
DR Genevisible; P0CE71; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR008080; Parvalbumin.
DR PANTHER; PTHR11653; PTHR11653; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 5: Uncertain;
KW Calcium; Metal-binding; Reference proteome; Repeat.
FT CHAIN 1..109
FT /note="Putative oncomodulin-2"
FT /id="PRO_0000392643"
FT DOMAIN 39..74
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 78..109
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 52
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P0CE72,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 54
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 56
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P0CE72,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 58
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P0CE72,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 63
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P0CE72,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 91
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 93
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P0CE72,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 95
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P0CE72,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 97
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P0CE72,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 102
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P0CE72,
FT ECO:0000255|PROSITE-ProRule:PRU00448"
SQ SEQUENCE 109 AA; 12129 MW; 5C7A0D3D25634A72 CRC64;
MSITDVLSAD DIAAALQECQ DPDTFEPQKF FQTSGLSKMS ASQVKDVFRF IDNDQSGYLD
EEELKFFLQK FESGARELTE SETKSLMAAA DNDGDGKIGA EEFQEMVHS
