OCSTP_HUMAN
ID OCSTP_HUMAN Reviewed; 566 AA.
AC Q9BR26;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Osteoclast stimulatory transmembrane protein;
DE Short=OC-STAMP;
GN Name=OCSTAMP; Synonyms=C20orf123;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-472.
RA Ashcroft K., Bethel G., Bye J.M., Howell G.R., Huckle E.J., Sheridan E.;
RL Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 454-566.
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable cell surface receptor that plays a role in cellular
CC fusion and cell differentiation. Cooperates with DCSTAMP in modulating
CC cell-cell fusion in both osteoclasts and foreign body giant cells
CC (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast
CC differentiation and may play a role in the multinucleated osteoclast
CC maturation (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AL935075; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL034424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL935075; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AL935089; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BX281477; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS54468.1; -.
DR RefSeq; NP_542452.1; NM_080721.2.
DR AlphaFoldDB; Q9BR26; -.
DR STRING; 9606.ENSP00000279028; -.
DR TCDB; 1.N.1.1.1; the osteoclast fusion complex (ofc) family.
DR PhosphoSitePlus; Q9BR26; -.
DR BioMuta; OCSTAMP; -.
DR DMDM; 193806176; -.
DR PaxDb; Q9BR26; -.
DR PRIDE; Q9BR26; -.
DR ProteomicsDB; 78739; -.
DR Antibodypedia; 28113; 17 antibodies from 9 providers.
DR DNASU; 128506; -.
DR Ensembl; ENST00000279028.3; ENSP00000279028.2; ENSG00000149635.3.
DR GeneID; 128506; -.
DR KEGG; hsa:128506; -.
DR MANE-Select; ENST00000279028.3; ENSP00000279028.2; NM_080721.3; NP_542452.1.
DR UCSC; uc010zxu.3; human.
DR CTD; 128506; -.
DR GeneCards; OCSTAMP; -.
DR HGNC; HGNC:16116; OCSTAMP.
DR HPA; ENSG00000149635; Not detected.
DR neXtProt; NX_Q9BR26; -.
DR OpenTargets; ENSG00000149635; -.
DR PharmGKB; PA25664; -.
DR VEuPathDB; HostDB:ENSG00000149635; -.
DR eggNOG; ENOG502QWNK; Eukaryota.
DR GeneTree; ENSGT00940000153269; -.
DR HOGENOM; CLU_045128_0_0_1; -.
DR InParanoid; Q9BR26; -.
DR OMA; WRSWHLG; -.
DR OrthoDB; 1224213at2759; -.
DR PhylomeDB; Q9BR26; -.
DR TreeFam; TF332562; -.
DR PathwayCommons; Q9BR26; -.
DR SignaLink; Q9BR26; -.
DR BioGRID-ORCS; 128506; 16 hits in 1062 CRISPR screens.
DR GenomeRNAi; 128506; -.
DR Pharos; Q9BR26; Tdark.
DR PRO; PR:Q9BR26; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9BR26; protein.
DR Bgee; ENSG00000149635; Expressed in adult mammalian kidney and 3 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0071391; P:cellular response to estrogen stimulus; ISS:UniProtKB.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; ISS:UniProtKB.
DR GO; GO:0072674; P:multinuclear osteoclast differentiation; ISS:UniProtKB.
DR GO; GO:0034241; P:positive regulation of macrophage fusion; IEA:Ensembl.
DR GO; GO:0045672; P:positive regulation of osteoclast differentiation; ISS:UniProtKB.
DR GO; GO:0090290; P:positive regulation of osteoclast proliferation; ISS:UniProtKB.
DR InterPro; IPR012858; DC_STAMP-like.
DR Pfam; PF07782; DC_STAMP; 1.
PE 2: Evidence at transcript level;
KW Differentiation; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..566
FT /note="Osteoclast stimulatory transmembrane protein"
FT /id="PRO_0000342121"
FT TOPO_DOM 1..51
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 73..81
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..128
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..227
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 249..304
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 305..325
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 326..398
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 399..419
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 420..566
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VARIANT 565
FT /note="P -> S (in dbSNP:rs847079)"
FT /id="VAR_050919"
SQ SEQUENCE 566 AA; 61579 MW; 3F2F24D0137F859E CRC64;
MPGHPGAAEQ LVKTGWRSWH LGFWKALAPL QAAWDAFSQP VPASCGQLLT QLLLCASLAA
AAAGLVYHWL ASLLLYPPGP SAMVATVCGL LVFLSLGLVP PVRCLFALSV PTLGMEQGRR
LLLSYSTATL AIAVVPNVLA NVGAAGQVLR CVTEGSLESL LNTTHQLHAA SRALGPTGQA
GSRGLTFEAQ DNGSAFYLHM LRVTQQVLED FSGLESLARA AALGTQRVVT GLFMLGLLVE
SAWYLHCYLT DLRFDNIYAT QQLTQRLAQA QATHLLAPPP TWLLQAAQLR LSQEELLSCL
LRLGLLALLL VATAVAVATD HVAFLLAQAT VDWAQKLPTV PITLTVKYDV AYTVLGFIPF
LFNQLAPESP FLSVHSSYQW ELRLTSARCP LLPARRPRAA APLAAGALQL LAGSTVLLEA
YARRLRHAIA ASFFTAQEAR RVRHLHARLQ RRHDRHQGQQ LPLGDPSCVP TPRPACKPPA
WIDYRLDALR TESSEGEGKE LWSCRDLSCN LGPVPPPCVT LGKSLHLSEP RFLHLHNDSI
FTIDVTYFPR RDVVRMEGNT GHDRPG
