OCT7_ARATH
ID OCT7_ARATH Reviewed; 500 AA.
AC Q940M4; Q9LSH7;
DT 25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Organic cation/carnitine transporter 7;
DE Short=AtOCT7;
GN Name=OCT7; Synonyms=7-Oct; OrderedLocusNames=At3g13050; ORFNames=MGH6.16;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP TISSUE SPECIFICITY [LARGE SCALE ANALYSIS].
RX PubMed=16607029; DOI=10.1104/pp.105.074708;
RA Bock K.W., Honys D., Ward J.M., Padmanaban S., Nawrocki E.P., Hirschi K.D.,
RA Twell D., Sze H.;
RT "Integrating membrane transport with male gametophyte development and
RT function through transcriptomics.";
RL Plant Physiol. 140:1151-1168(2006).
CC -!- FUNCTION: High affinity carnitine transporter involved in the active
CC cellular uptake of carnitine. Also transports organic cations (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in pollen. {ECO:0000269|PubMed:16607029}.
CC -!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily.
CC Organic cation transporter (TC 2.A.1.19) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB02515.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB026645; BAB02515.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE75283.1; -; Genomic_DNA.
DR EMBL; CP002686; ANM64437.1; -; Genomic_DNA.
DR EMBL; CP002686; ANM64438.1; -; Genomic_DNA.
DR EMBL; CP002686; ANM64439.1; -; Genomic_DNA.
DR EMBL; AY054262; AAL06921.1; -; mRNA.
DR EMBL; BT004522; AAO42768.1; -; mRNA.
DR RefSeq; NP_001326466.1; NM_001338024.1.
DR RefSeq; NP_001326467.1; NM_001338025.1.
DR RefSeq; NP_001326468.1; NM_001338023.1.
DR RefSeq; NP_187911.1; NM_112142.4.
DR AlphaFoldDB; Q940M4; -.
DR SMR; Q940M4; -.
DR BioGRID; 5825; 1.
DR IntAct; Q940M4; 1.
DR STRING; 3702.AT3G13050.1; -.
DR PaxDb; Q940M4; -.
DR PRIDE; Q940M4; -.
DR ProteomicsDB; 250867; -.
DR EnsemblPlants; AT3G13050.1; AT3G13050.1; AT3G13050.
DR EnsemblPlants; AT3G13050.2; AT3G13050.2; AT3G13050.
DR EnsemblPlants; AT3G13050.3; AT3G13050.3; AT3G13050.
DR EnsemblPlants; AT3G13050.4; AT3G13050.4; AT3G13050.
DR GeneID; 820491; -.
DR Gramene; AT3G13050.1; AT3G13050.1; AT3G13050.
DR Gramene; AT3G13050.2; AT3G13050.2; AT3G13050.
DR Gramene; AT3G13050.3; AT3G13050.3; AT3G13050.
DR Gramene; AT3G13050.4; AT3G13050.4; AT3G13050.
DR KEGG; ath:AT3G13050; -.
DR Araport; AT3G13050; -.
DR TAIR; locus:2089270; AT3G13050.
DR eggNOG; KOG0253; Eukaryota.
DR HOGENOM; CLU_001265_46_0_1; -.
DR InParanoid; Q940M4; -.
DR OMA; EIFPTKD; -.
DR OrthoDB; 1430447at2759; -.
DR PhylomeDB; Q940M4; -.
DR PRO; PR:Q940M4; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q940M4; baseline and differential.
DR Genevisible; Q940M4; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0090417; F:N-methylnicotinate transmembrane transporter activity; IDA:TAIR.
DR GO; GO:0090416; F:nicotinate transmembrane transporter activity; IDA:TAIR.
DR GO; GO:2001143; P:N-methylnicotinate transport; IDA:TAIR.
DR GO; GO:2001142; P:nicotinate transport; IDA:TAIR.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Glycoprotein; Ion transport; Membrane; Nucleotide-binding;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..500
FT /note="Organic cation/carnitine transporter 7"
FT /id="PRO_0000415363"
FT TOPO_DOM 1..23
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..62
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 84..97
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..120
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 142..150
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172..174
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 196..293
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 315..341
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 342..362
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 363..367
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 368..387
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 388..401
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 402..422
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 423..429
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 430..450
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 451..456
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 457..477
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 478..500
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT BINDING 137..144
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT CARBOHYD 56
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 319
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 500 AA; 54573 MW; EC459EB09EF581C5 CRC64;
MADGNTRFTV DEALVAMGFG KFQIYVLAYA GMGWVAEAME MMLLSFVGPA VQSLWNLSAR
QESLITSVVF AGMLIGAYSW GIVSDKHGRR KGFIITAVVT FVAGFLSAFS PNYMWLIILR
CLVGLGLGGG PVLASWYLEF IPAPSRGTWM VVFSAFWTVG TIFEASLAWL VMPRLGWRWL
LAFSSVPSSL LLLFYRWTSE SPRYLILQGR KAEALAILEK IARMNKTQLP PGVLSSELET
ELEENKNIPT ENTHLLKAGE SGEAVAVSKI VLKADKEPGF SLLALLSPTL MKRTLLLWVV
FFGNAFAYYG VVLLTTELNN SHNRCYPTEK QLRNSNDVNY RDVFIASFAE FPGLLISAAM
VDRLGRKASM ASMLFTCCIF LLPLLSHQSP FITTVLLFGG RICISAAFTV VYIYAPEIYP
TAVRTTGVGV GSSVGRIGGI LCPLVAVGLV HGCHQTIAVL LFEVVILVSG ICVCLFPFET
SGRDLTDSIS ASKEPPSASV
