OCTB3_DROME
ID OCTB3_DROME Reviewed; 1256 AA.
AC Q4LBB6; A0AVV1; Q2PDR1; Q2PDR2; Q2PDR3; Q2PDR4; Q2PDR5; Q2PDR6; Q4LBB5;
AC Q4LBB7; Q4LBB8; Q8INI6; Q8INI7; Q9VG56; Q9VG57;
DT 11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-SEP-2011, sequence version 4.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Octopamine receptor beta-3R;
DE Short=DmOct-beta-3R;
GN Name=Octbeta3R {ECO:0000312|FlyBase:FBgn0250910}; Synonyms=Oct-beta-3;
GN ORFNames=CG42244 {ECO:0000312|FlyBase:FBgn0250910};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000305, ECO:0000312|EMBL:CAI56424.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C AND D).
RC TISSUE=Head {ECO:0000312|EMBL:CAI56424.1};
RX PubMed=15998303; DOI=10.1111/j.1471-4159.2005.03251.x;
RA Maqueira B., Chatwin H., Evans P.D.;
RT "Identification and characterization of a novel family of Drosophila beta-
RT adrenergic-like octopamine G-protein coupled receptors.";
RL J. Neurochem. 94:547-560(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3] {ECO:0000305}
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM F).
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J., Frise E., Kapadia B., Park S., Wan K., Yu C.,
RA Celniker S.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=22303848; DOI=10.2108/zsj.29.83;
RA Ohhara Y., Kayashima Y., Hayashi Y., Kobayashi S., Yamakawa-Kobayashi K.;
RT "Expression of beta-adrenergic-like octopamine receptors during Drosophila
RT development.";
RL Zool. Sci. 29:83-89(2012).
RN [6]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=25605909; DOI=10.1073/pnas.1414966112;
RA Ohhara Y., Shimada-Niwa Y., Niwa R., Kayashima Y., Hayashi Y., Akagi K.,
RA Ueda H., Yamakawa-Kobayashi K., Kobayashi S.;
RT "Autocrine regulation of ecdysone synthesis by beta3-octopamine receptor in
RT the prothoracic gland is essential for Drosophila metamorphosis.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:1452-1457(2015).
CC -!- FUNCTION: Autoreceptor for octopamine, which is a neurotransmitter,
CC neurohormone, and neuromodulator in invertebrates (By similarity).
CC Probably also acts as a receptor for tyramine during ecdysone
CC biosynthesis (PubMed:25605909). Required for the biosynthesis of the
CC steroid hormone ecdysone which is necessary for metamorphosis
CC (PubMed:25605909). Involved in activation of prothoracicotropic hormone
CC and insulin-like peptide signaling which is required for the expression
CC of ecdysone biosynthetic genes (PubMed:25605909).
CC {ECO:0000250|UniProtKB:Q9VCZ3, ECO:0000269|PubMed:25605909}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=8;
CC Name=F;
CC IsoId=Q4LBB6-6; Sequence=Displayed;
CC Name=D {ECO:0000269|PubMed:15998303}; Synonyms=variant A
CC {ECO:0000303|PubMed:15998303};
CC IsoId=Q4LBB6-4; Sequence=VSP_041777;
CC Name=A {ECO:0000269|PubMed:15998303}; Synonyms=variant D
CC {ECO:0000303|PubMed:15998303};
CC IsoId=Q4LBB6-2; Sequence=VSP_051835;
CC Name=B {ECO:0000269|PubMed:15998303}; Synonyms=variant C
CC {ECO:0000303|PubMed:15998303};
CC IsoId=Q4LBB6-1; Sequence=VSP_041779, VSP_041782;
CC Name=C {ECO:0000269|PubMed:15998303}; Synonyms=variant B
CC {ECO:0000303|PubMed:15998303};
CC IsoId=Q4LBB6-3; Sequence=VSP_051837;
CC Name=G;
CC IsoId=Q4LBB6-7; Sequence=VSP_041783;
CC Name=J;
CC IsoId=Q4LBB6-8; Sequence=VSP_041778;
CC Name=H;
CC IsoId=Q4LBB6-9; Sequence=VSP_041780, VSP_041781;
CC -!- TISSUE SPECIFICITY: In the adult, expressed in the inferior and
CC superior protocerebrum, the posterior lateral protocerebrum, the
CC deutocerebrum, the surface of the subesophageal ganglion, the lateral
CC cell body region, the cortical layer of the ventral nerve cord and the
CC optic lobe medulla of the central nervous system (CNS). Also expressed
CC in the nurse cells and follicle cells of the egg chambers in the ovary
CC at oogenic stages 1-10, and spermatogonia and spermatocytes in the
CC testis. Expressed ubiquitously in the embryonic CNS. In larvae,
CC expressed in the ventral cortical layer of the ventral nerve cord, the
CC cortical layer of the brain lobes, salivary glands, midgut, imaginal
CC disks and developing reproductive organs. Expressed in the larval
CC prothoracic gland with weak expression in other regions of the ring
CC gland. {ECO:0000269|PubMed:22303848}.
CC -!- DEVELOPMENTAL STAGE: Levels peak during the late embryonic stages.
CC Slight increase in expression at the mid-larval stage that decreases
CC over the pupal stage and then slightly increases in the adult.
CC {ECO:0000269|PubMed:22303848}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown in the prothoracic gland
CC results in developmental arrest at the larval stage. This larval-
CC prepual arrest can be rescued by supplementing larvae diet with 20-
CC hydroxyecdysone (20E). {ECO:0000269|PubMed:25605909}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AJ884591; CAI56424.1; -; mRNA.
DR EMBL; AJ884592; CAI56425.1; -; mRNA.
DR EMBL; AJ884593; CAI56426.1; -; mRNA.
DR EMBL; AJ884594; CAI56427.1; -; mRNA.
DR EMBL; AE014297; AAF54832.2; -; Genomic_DNA.
DR EMBL; AE014297; ABC66171.2; -; Genomic_DNA.
DR EMBL; AE014297; ABC66172.2; -; Genomic_DNA.
DR EMBL; AE014297; ABC66173.2; -; Genomic_DNA.
DR EMBL; BT029269; ABK30906.1; -; mRNA.
DR RefSeq; NP_001034043.2; NM_001038954.2. [Q4LBB6-8]
DR RefSeq; NP_001034046.3; NM_001038957.3. [Q4LBB6-1]
DR RefSeq; NP_001034048.2; NM_001038959.3. [Q4LBB6-6]
DR RefSeq; NP_650210.2; NM_141953.3. [Q4LBB6-7]
DR AlphaFoldDB; Q4LBB6; -.
DR SMR; Q4LBB6; -.
DR IntAct; Q4LBB6; 3.
DR STRING; 7227.FBpp0288773; -.
DR GlyGen; Q4LBB6; 4 sites.
DR PaxDb; Q4LBB6; -.
DR PRIDE; Q4LBB6; -.
DR EnsemblMetazoa; FBtr0290334; FBpp0288773; FBgn0250910. [Q4LBB6-6]
DR EnsemblMetazoa; FBtr0290335; FBpp0288774; FBgn0250910. [Q4LBB6-7]
DR EnsemblMetazoa; FBtr0301944; FBpp0291156; FBgn0250910. [Q4LBB6-8]
DR EnsemblMetazoa; FBtr0308597; FBpp0300821; FBgn0250910. [Q4LBB6-1]
DR GeneID; 3885573; -.
DR KEGG; dme:Dmel_CG42244; -.
DR UCSC; CG42244-RB; d. melanogaster.
DR CTD; 3885573; -.
DR FlyBase; FBgn0250910; Octbeta3R.
DR VEuPathDB; VectorBase:FBgn0250910; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000171582; -.
DR InParanoid; Q4LBB6; -.
DR OMA; THRVCSA; -.
DR PhylomeDB; Q4LBB6; -.
DR Reactome; R-DME-390651; Dopamine receptors.
DR Reactome; R-DME-390696; Adrenoceptors.
DR Reactome; R-DME-418555; G alpha (s) signalling events.
DR Reactome; R-DME-5689880; Ub-specific processing proteases.
DR Reactome; R-DME-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR Reactome; R-DME-8856828; Clathrin-mediated endocytosis.
DR BioGRID-ORCS; 3885573; 0 hits in 1 CRISPR screen.
DR ChiTaRS; Octbeta3R; fly.
DR GenomeRNAi; 3885573; -.
DR PRO; PR:Q4LBB6; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0250910; Expressed in brain and 6 other tissues.
DR Genevisible; Q4LBB6; DM.
DR GO; GO:0016021; C:integral component of membrane; ISS:FlyBase.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:FlyBase.
DR GO; GO:0008227; F:G protein-coupled amine receptor activity; ISS:FlyBase.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0004989; F:octopamine receptor activity; IDA:FlyBase.
DR GO; GO:0071880; P:adenylate cyclase-activating adrenergic receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IDA:FlyBase.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:FlyBase.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; G-protein coupled receptor;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..1256
FT /note="Octopamine receptor beta-3R"
FT /id="PRO_0000069961"
FT TOPO_DOM 1..143
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..171
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 193..213
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..236
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 237..258
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..279
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 280..305
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..326
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 327..1169
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1170..1190
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1191..1202
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1203..1223
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1224..1256
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 377..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 665..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 751..774
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1087..1117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..508
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..692
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 755..769
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 36
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 113
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 117
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 196
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 262..1166
FT /note="Missing (in isoform A)"
FT /evidence="ECO:0000303|PubMed:15998303"
FT /id="VSP_051835"
FT VAR_SEQ 331..1256
FT /note="Missing (in isoform C)"
FT /evidence="ECO:0000303|PubMed:15998303"
FT /id="VSP_051837"
FT VAR_SEQ 351..1166
FT /note="Missing (in isoform D)"
FT /evidence="ECO:0000303|PubMed:15998303"
FT /id="VSP_041777"
FT VAR_SEQ 351..1161
FT /note="Missing (in isoform J)"
FT /evidence="ECO:0000305"
FT /id="VSP_041778"
FT VAR_SEQ 390..456
FT /note="DMLQPATDEDDDRDECDELRVPSPPPRRLSRSSIDLRDLEQERYEKVTHTDS
FT APSMMALQQQQPSHN -> AVPCDRPKDGRPNTRPPAPWASSWASFCSAGCPSFCGMSS
FT HRSAVRPAHVPMCSWWCYSGSVTSTPR (in isoform B)"
FT /evidence="ECO:0000303|PubMed:15998303"
FT /id="VSP_041779"
FT VAR_SEQ 390..395
FT /note="DMLQPA -> VSLEGY (in isoform H)"
FT /evidence="ECO:0000305"
FT /id="VSP_041780"
FT VAR_SEQ 396..1256
FT /note="Missing (in isoform H)"
FT /evidence="ECO:0000305"
FT /id="VSP_041781"
FT VAR_SEQ 457..1256
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000303|PubMed:15998303"
FT /id="VSP_041782"
FT VAR_SEQ 1013..1151
FT /note="KHEFSNKSSLIRRGGICIFVDEEEAEIIEQRPRGITFAAVPSPLPKCPLCGA
FT DISSTTGTTANATATANADSTIDTTVTTSSKRSIHEQTPDLGQRPASSSSSTRFWHKRT
FT AAVTACWQQSKNRKRRFKTGCSHCGATG -> S (in isoform G)"
FT /evidence="ECO:0000305"
FT /id="VSP_041783"
FT CONFLICT 12
FT /note="T -> A (in Ref. 1; CAI56425)"
FT /evidence="ECO:0000305"
FT CONFLICT 98
FT /note="L -> S (in Ref. 1; CAI56426)"
FT /evidence="ECO:0000305"
FT CONFLICT 122
FT /note="A -> T (in Ref. 1; CAI56424/CAI56425/CAI56426/
FT CAI56427)"
FT /evidence="ECO:0000305"
FT CONFLICT 132
FT /note="S -> G (in Ref. 1; CAI56426)"
FT /evidence="ECO:0000305"
FT CONFLICT 211
FT /note="F -> L (in Ref. 1; CAI56426)"
FT /evidence="ECO:0000305"
FT CONFLICT 211
FT /note="F -> P (in Ref. 1; CAI56425)"
FT /evidence="ECO:0000305"
FT CONFLICT 262
FT /note="A -> TSSA (in Ref. 1; CAI56427)"
FT /evidence="ECO:0000305"
FT CONFLICT 320
FT /note="V -> L (in Ref. 4; ABK30906)"
FT /evidence="ECO:0000305"
FT CONFLICT 679
FT /note="K -> R (in Ref. 4; ABK30906)"
FT /evidence="ECO:0000305"
FT CONFLICT 852
FT /note="Y -> C (in Ref. 4; ABK30906)"
FT /evidence="ECO:0000305"
FT CONFLICT 1186
FT /note="L -> M (in Ref. 1; CAI56427)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1256 AA; 136370 MW; 9DA3CF6523B94A69 CRC64;
MSGVNVADLL ATTMTLPITA AAGAATSQAA ATSATNASHL QPATLTGHIS TTAAAKTTTT
PTSSLPITSQ FVDASLTSLS LTATSSDASY SSPFSSYLSS DSTFELLSTV GPNITANGSD
IAVDNQAELE ESWLDLSLLL LKGFIFSSII LAAVLGNALV IISVQRNRKL RVITNYFVVS
LAMADMLVAL CAMTFNASVE LSGGKWMFGP FMCNVYNSLD VYFSTASILH LCCISVDRYY
AIVRPLEYPL NMTHKTVCFM LANVWILPAL ISFTPIFLGW YTTEEHLREI SLHPDQCSFV
VNKAYALISS SVSFWIPGIV MLVMYWRIFK EAIRQRKALS RTSSNILLNS VHMGHTQQPT
SLSYLHPSDC DLNATSAREE THSALSNLED MLQPATDEDD DRDECDELRV PSPPPRRLSR
SSIDLRDLEQ ERYEKVTHTD SAPSMMALQQ QQPSHNQLQP PAPVFNPQIW TEGKMIPSKE
LDKEHSHPNG PQQQLSLTSG SGNSEPEPES TAYRVFGGLN SDESEGNDLY DTHLPLAEDN
KELKRLIEDN YLYFKRQTGG TIISGPGGGK YAALSETDFI RLKAGAAACG RKAFASSDSE
FLRTISESRA LPEQPVPGKE KGFNILSLLS KTKRSSTECF TLEKKRHQAN SEGSSFFRRS
RNRKLSHSYN GCGGGKERKL ERRQRQHSDT DSTPNKPDIL LDINVLSEQS GASVIQQFSD
GVQLIDFSEL KTPPERIRSD DELAQLADCF GESPQQPATP PPSLSPPELP EPSGLLIASS
SELAEIFRSL SFPLGRPAGA PQRLSTLSDQ VCANYLMSPP NTPAPPAISV PNGGAMDSSA
SSNAQSASIN VYFLSPPPHA AAPGYTPSDT STVSLDVVTS LPMPVPVPQP NPQMASQSNI
SPKPEIILDS TLSPVEGCGD EHRDVTSPLF KRKDSAGDAD VSVSGNGGAG GVGGVGGRQG
RCSILAGYDG IQTVRKRQAS VVTYDVNVIN FSQENSDSRS YIPMGRVSTS SAKHEFSNKS
SLIRRGGICI FVDEEEAEII EQRPRGITFA AVPSPLPKCP LCGADISSTT GTTANATATA
NADSTIDTTV TTSSKRSIHE QTPDLGQRPA SSSSSTRFWH KRTAAVTACW QQSKNRKRRF
KTGCSHCGAT GGSVRPAKGW KAEHKAARTL GIIMGVFLLC WLPFFLWYVI TSLCGPACPC
PDVLVVVLFW IGYFNSTLNP LIYAYFNRDF REAFRNTLEC VLPCLEKRNP YNAYYV
