OD3L2_HUMAN
ID OD3L2_HUMAN Reviewed; 289 AA.
AC Q3SX64; Q3SX65; Q8N1L2;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Outer dense fiber protein 3-like protein 2;
GN Name=ODF3L2; Synonyms=C19orf19;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Colon;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT ALA-135.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
CC -!- INTERACTION:
CC Q3SX64; P55212: CASP6; NbExp=3; IntAct=EBI-6660184, EBI-718729;
CC Q3SX64; P28329-3: CHAT; NbExp=3; IntAct=EBI-6660184, EBI-25837549;
CC Q3SX64; P22607: FGFR3; NbExp=3; IntAct=EBI-6660184, EBI-348399;
CC Q3SX64; P14136: GFAP; NbExp=3; IntAct=EBI-6660184, EBI-744302;
CC Q3SX64; P30519: HMOX2; NbExp=3; IntAct=EBI-6660184, EBI-712096;
CC Q3SX64; O75031: HSF2BP; NbExp=3; IntAct=EBI-6660184, EBI-7116203;
CC Q3SX64; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-6660184, EBI-1055254;
CC Q3SX64; P02545: LMNA; NbExp=3; IntAct=EBI-6660184, EBI-351935;
CC Q3SX64; Q96CV9: OPTN; NbExp=3; IntAct=EBI-6660184, EBI-748974;
CC Q3SX64; P62826: RAN; NbExp=3; IntAct=EBI-6660184, EBI-286642;
CC Q3SX64; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-6660184, EBI-5235340;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3SX64-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3SX64-2; Sequence=VSP_022778;
CC -!- SIMILARITY: Belongs to the ODF3 family. {ECO:0000305}.
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DR EMBL; AK097378; BAC05028.1; -; mRNA.
DR EMBL; BC104468; AAI04469.1; -; mRNA.
DR EMBL; BC104469; AAI04470.1; -; mRNA.
DR CCDS; CCDS12027.1; -. [Q3SX64-1]
DR RefSeq; NP_872383.1; NM_182577.2. [Q3SX64-1]
DR AlphaFoldDB; Q3SX64; -.
DR BioGRID; 129881; 15.
DR IntAct; Q3SX64; 17.
DR STRING; 9606.ENSP00000318029; -.
DR GlyGen; Q3SX64; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q3SX64; -.
DR PhosphoSitePlus; Q3SX64; -.
DR BioMuta; ODF3L2; -.
DR DMDM; 125888011; -.
DR MassIVE; Q3SX64; -.
DR PaxDb; Q3SX64; -.
DR PeptideAtlas; Q3SX64; -.
DR PRIDE; Q3SX64; -.
DR Antibodypedia; 67090; 31 antibodies from 11 providers.
DR DNASU; 284451; -.
DR Ensembl; ENST00000315489.5; ENSP00000318029.2; ENSG00000181781.10. [Q3SX64-1]
DR Ensembl; ENST00000382696.7; ENSP00000372143.2; ENSG00000181781.10. [Q3SX64-2]
DR GeneID; 284451; -.
DR KEGG; hsa:284451; -.
DR MANE-Select; ENST00000315489.5; ENSP00000318029.2; NM_182577.3; NP_872383.1.
DR UCSC; uc002lor.3; human. [Q3SX64-1]
DR CTD; 284451; -.
DR GeneCards; ODF3L2; -.
DR HGNC; HGNC:26841; ODF3L2.
DR HPA; ENSG00000181781; Group enriched (skeletal muscle, testis).
DR neXtProt; NX_Q3SX64; -.
DR OpenTargets; ENSG00000181781; -.
DR PharmGKB; PA162398387; -.
DR VEuPathDB; HostDB:ENSG00000181781; -.
DR eggNOG; ENOG502QRKE; Eukaryota.
DR GeneTree; ENSGT00940000160480; -.
DR HOGENOM; CLU_088282_1_0_1; -.
DR InParanoid; Q3SX64; -.
DR OMA; YVNHDCT; -.
DR OrthoDB; 920847at2759; -.
DR PhylomeDB; Q3SX64; -.
DR TreeFam; TF325804; -.
DR PathwayCommons; Q3SX64; -.
DR SignaLink; Q3SX64; -.
DR BioGRID-ORCS; 284451; 9 hits in 1065 CRISPR screens.
DR GenomeRNAi; 284451; -.
DR Pharos; Q3SX64; Tdark.
DR PRO; PR:Q3SX64; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q3SX64; protein.
DR Bgee; ENSG00000181781; Expressed in right testis and 107 other tissues.
DR Genevisible; Q3SX64; HS.
DR GO; GO:0005881; C:cytoplasmic microtubule; IDA:UniProtKB.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR InterPro; IPR010736; SHIPPO-rpt.
DR Pfam; PF07004; SHIPPO-rpt; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Repeat.
FT CHAIN 1..289
FT /note="Outer dense fiber protein 3-like protein 2"
FT /id="PRO_0000274520"
FT REPEAT 122..148
FT /note="STPGR 1"
FT REPEAT 202..227
FT /note="STPGR 2"
FT REPEAT 238..263
FT /note="STPGR 3"
FT REGION 108..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 181..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 265..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 43..78
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_022778"
FT VARIANT 135
FT /note="V -> A (in dbSNP:rs34551779)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_053951"
SQ SEQUENCE 289 AA; 30781 MW; 79748C1683D5935C CRC64;
MGTLSCDSTP RLATAPLGRR VTEGQIPETG LRKSCGTATL ENGSGPGLYV LPSTVGFINH
DCTRVASPAY SLVRRPSEAP PQDTSPGPIY FLDPKVTRFG RSCTPAYSMQ GRAKSRGPEV
TPGPGAYSPE KVPPVRHRTP PAFTLGCRLP LKPLDTSAPA PNAYTMPPLW GSQIFTKPSS
PSYTVVGRTP PARPPQDPAE IPGPGQYDSP DANTYRQRLP AFTMLGRPRA PRPLEETPGP
GAHCPEQVTV NKARAPAFSM GIRHSKRAST MAATTPSRPA GHRLPGRCC
