ODAD1_MOUSE
ID ODAD1_MOUSE Reviewed; 658 AA.
AC Q3UX62; Q91WT0;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Outer dynein arm-docking complex subunit 1;
DE AltName: Full=Coiled-coil domain-containing protein 114;
GN Name=Odad1; Synonyms=Ccdc114 {ECO:0000312|MGI:MGI:2446120};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Egg;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 173-658.
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=23261303; DOI=10.1016/j.ajhg.2012.11.002;
RA Onoufriadis A., Paff T., Antony D., Shoemark A., Micha D., Kuyt B.,
RA Schmidts M., Petridi S., Dankert-Roelse J.E., Haarman E.G., Daniels J.M.,
RA Emes R.D., Wilson R., Hogg C., Scambler P.J., Chung E.M., Pals G.,
RA Mitchison H.M.;
RT "Splice-Site mutations in the axonemal outer dynein arm docking complex
RT gene CCDC114 cause primary ciliary dyskinesia.";
RL Am. J. Hum. Genet. 92:88-98(2013).
CC -!- FUNCTION: Component of the outer dynein arm-docking complex that
CC mediates outer dynein arms (ODA) binding onto the doublet microtubule.
CC Involved in mediating assembly of both ODAs and their axonemal docking
CC complex onto ciliary microtubules (By similarity).
CC {ECO:0000250|UniProtKB:F1N2N9, ECO:0000250|UniProtKB:Q96M63}.
CC -!- SUBUNIT: Component of the outer dynein arm-docking complex along with
CC ODAD2, ODAD3, ODAD4 and CLXN. Interacts with ODAD3. Interacts with
CC ODAD4; this interaction may facilitate the recruitment and/or
CC attachment of outer dynein arm docking complex proteins including
CC ODAD1, ODAD3, and ODAD4 to ciliary axonemes. Interacts with DNAH9.
CC Interacts with MNS1 (By similarity). Interacts with PIERCE1 and
CC PIERCE2; the interactions link the outer dynein arms docking complex
CC (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium
CC axoneme (By similarity). {ECO:0000250|UniProtKB:F1N2N9,
CC ECO:0000250|UniProtKB:Q96M63}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:Q96M63}.
CC -!- TISSUE SPECIFICITY: Expressed in motile ciliated tissues.
CC {ECO:0000269|PubMed:23261303}.
CC -!- SIMILARITY: Belongs to the ODA1/DCC2 family. {ECO:0000305}.
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DR EMBL; AK135860; BAE22701.1; -; mRNA.
DR EMBL; BC013491; AAH13491.1; -; mRNA.
DR RefSeq; NP_001028415.1; NM_001033243.2.
DR AlphaFoldDB; Q3UX62; -.
DR SMR; Q3UX62; -.
DR BioGRID; 229242; 3.
DR STRING; 10090.ENSMUSP00000042772; -.
DR iPTMnet; Q3UX62; -.
DR PhosphoSitePlus; Q3UX62; -.
DR EPD; Q3UX62; -.
DR MaxQB; Q3UX62; -.
DR PaxDb; Q3UX62; -.
DR PRIDE; Q3UX62; -.
DR ProteomicsDB; 265576; -.
DR DNASU; 211535; -.
DR Ensembl; ENSMUST00000038720; ENSMUSP00000042772; ENSMUSG00000040189.
DR UCSC; uc009gxz.1; mouse.
DR MGI; MGI:2446120; Odad1.
DR VEuPathDB; HostDB:ENSMUSG00000040189; -.
DR eggNOG; ENOG502QSIU; Eukaryota.
DR GeneTree; ENSGT00950000183364; -.
DR HOGENOM; CLU_027546_3_1_1; -.
DR InParanoid; Q3UX62; -.
DR OMA; HCDGSMI; -.
DR OrthoDB; 648380at2759; -.
DR PhylomeDB; Q3UX62; -.
DR TreeFam; TF323742; -.
DR BioGRID-ORCS; 211535; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Ccdc114; mouse.
DR PRO; PR:Q3UX62; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q3UX62; protein.
DR Bgee; ENSMUSG00000040189; Expressed in choroid plexus of lateral ventricle and 81 other tissues.
DR ExpressionAtlas; Q3UX62; baseline and differential.
DR Genevisible; Q3UX62; MM.
DR GO; GO:0005930; C:axoneme; ISO:MGI.
DR GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR GO; GO:0036157; C:outer dynein arm; ISS:UniProtKB.
DR GO; GO:0120228; C:outer dynein arm docking complex; ISS:UniProtKB.
DR GO; GO:0003341; P:cilium movement; ISS:UniProtKB.
DR GO; GO:0036158; P:outer dynein arm assembly; ISS:UniProtKB.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..658
FT /note="Outer dynein arm-docking complex subunit 1"
FT /id="PRO_0000288808"
FT REGION 496..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 574..658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 11..156
FT /evidence="ECO:0000255"
FT COILED 186..234
FT /evidence="ECO:0000255"
FT COILED 303..380
FT /evidence="ECO:0000255"
FT COMPBIAS 505..525
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..552
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 500
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:B1H228"
FT MOD_RES 506
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:B1H228"
FT MOD_RES 507
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:B1H228"
FT MOD_RES 509
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:B1H228"
SQ SEQUENCE 658 AA; 74120 MW; 2D963762993C48B8 CRC64;
MMELERRAYS KEVHQRLRKQ VEEIRQLEML RAKLQTQINV AQSQVKRLGD KKHLAEMECL
LKSRAQVQVE IEALQEQNRA LDKQIQDWET HVLTQSKEAS APDLIMYQKM KIQRRIRILE
DQLDRVTCHF DIHLVRNAAL REELELLRIE RGRYLNMDRK LKKEIHLLRE MVGALSTSST
SAYTAREEAK TKMGMLQERA EKELAQSDTE AQILLRQISH LEQLHRFLKL KNDERQPDPR
VVQKAEQRDW EVSEGLRKTS QEKLVLRYED TLGKLAQLTG ESDPDLLVEK YLELEERNFA
EFNFINEQNS EIHHLQEEIK EMQEALVSEH ASQDKQRMQQ EQQCKMLQQD VDKMCSESEQ
LEGRFQVLRG QLEKIKTDIQ VLFDKAKCDS SVIKDLLGVK TYMRDRDIGL FLSTIERRLV
QLLTVQAFLQ VQNLAPLADA ALLALGQSLQ EPSKKTTPLK PPDTMEDSSG AVIKEDYPMS
KEELLSQVMK SLQLQDEEES AKKLDSSPSL TLSSPQISLV TVPKHSKKTS VVPESILSHK
TNRGRGTGSV SHVTFGDSAS AAGPVAMASA SASGAPVSSR SSQGGRGGFK PTSSSSYLGS
TGYLETSRGR ESTAGGVHSQ SMGSELSRGL SSSSGHASSP APPSRPSSST SKDSRGYN
