ODAD2_BOVIN
ID ODAD2_BOVIN Reviewed; 1044 AA.
AC E1B8W3;
DT 03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT 10-APR-2019, sequence version 3.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Outer dynein arm-docking complex subunit 2;
DE AltName: Full=Armadillo repeat-containing protein 4 {ECO:0000303|PubMed:34715025};
GN Name=ODAD2 {ECO:0000312|VGNC:VGNC:26158};
GN Synonyms=ARMC4 {ECO:0000303|PubMed:34715025};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000312|Proteomes:UP000009136};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford;
RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT "A whole-genome assembly of the domestic cow, Bos taurus.";
RL Genome Biol. 10:R42.01-R42.10(2009).
RN [2] {ECO:0007744|PDB:7RRO}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS), SUBUNIT, FUNCTION,
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=34715025; DOI=10.1016/j.cell.2021.10.007;
RA Gui M., Farley H., Anujan P., Anderson J.R., Maxwell D.W., Whitchurch J.B.,
RA Botsch J.J., Qiu T., Meleppattu S., Singh S.K., Zhang Q., Thompson J.,
RA Lucas J.S., Bingle C.D., Norris D.P., Roy S., Brown A.;
RT "De novo identification of mammalian ciliary motility proteins using cryo-
RT EM.";
RL Cell 184:5791-5806.e19(2021).
CC -!- FUNCTION: Component of the outer dynein arm-docking complex (ODA-DC)
CC that mediates outer dynein arms (ODA) binding onto the doublet
CC microtubule. Involved in mediating assembly of both ODAs and their
CC axonemal docking complex onto ciliary microtubules.
CC {ECO:0000269|PubMed:34715025}.
CC -!- SUBUNIT: Component of the outer dynein arm-docking complex along with
CC ODAD1, ODAD3, ODAD4 and CLXN. {ECO:0000269|PubMed:34715025}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000269|PubMed:34715025}. Cytoplasm, cytoskeleton, cilium basal
CC body {ECO:0000250|UniProtKB:Q5T2S8}.
CC -!- TISSUE SPECIFICITY: Expressed in trachea multiciliated cells.
CC {ECO:0000269|PubMed:34715025}.
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DR RefSeq; NP_001179560.1; NM_001192631.1.
DR PDB; 7RRO; EM; 3.40 A; H7/H8/H9=1-1044.
DR PDBsum; 7RRO; -.
DR SMR; E1B8W3; -.
DR STRING; 9913.ENSBTAP00000000861; -.
DR PaxDb; E1B8W3; -.
DR Ensembl; ENSBTAT00000000861.6; ENSBTAP00000000861.6; ENSBTAG00000000654.6.
DR GeneID; 526515; -.
DR KEGG; bta:526515; -.
DR CTD; 55130; -.
DR VEuPathDB; HostDB:ENSBTAG00000000654; -.
DR VGNC; VGNC:26158; ODAD2.
DR eggNOG; KOG0167; Eukaryota.
DR GeneTree; ENSGT00940000156625; -.
DR HOGENOM; CLU_011703_0_0_1; -.
DR InParanoid; E1B8W3; -.
DR OMA; DAIARCC; -.
DR OrthoDB; 310809at2759; -.
DR TreeFam; TF324155; -.
DR Proteomes; UP000009136; Chromosome 13.
DR Bgee; ENSBTAG00000000654; Expressed in oviduct epithelium and 61 other tissues.
DR GO; GO:0097546; C:ciliary base; IEA:Ensembl.
DR GO; GO:0120228; C:outer dynein arm docking complex; ISS:UniProtKB.
DR GO; GO:0003341; P:cilium movement; IDA:UniProtKB.
DR GO; GO:0007368; P:determination of left/right symmetry; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0036158; P:outer dynein arm assembly; IDA:UniProtKB.
DR GO; GO:0003356; P:regulation of cilium beat frequency; IEA:Ensembl.
DR GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR Gene3D; 1.25.10.10; -; 4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR Pfam; PF00514; Arm; 1.
DR SMART; SM00185; ARM; 13.
DR SUPFAM; SSF48371; SSF48371; 2.
DR PROSITE; PS50176; ARM_REPEAT; 4.
PE 1: Evidence at protein level;
KW 3D-structure; Cell projection; Cytoplasm; Cytoskeleton; Reference proteome;
KW Repeat.
FT CHAIN 1..1044
FT /note="Outer dynein arm-docking complex subunit 2"
FT /id="PRO_0000456156"
FT REPEAT 448..485
FT /note="HEAT 1"
FT /evidence="ECO:0000255"
FT REPEAT 484..523
FT /note="ARM 3"
FT /evidence="ECO:0000255"
FT REPEAT 487..527
FT /note="HEAT 2"
FT /evidence="ECO:0000255"
FT REPEAT 525..564
FT /note="ARM 4"
FT /evidence="ECO:0000255"
FT REPEAT 530..568
FT /note="HEAT 3"
FT /evidence="ECO:0000255"
FT REPEAT 535..577
FT /note="ARM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00259"
FT REPEAT 622..661
FT /note="ARM 5"
FT /evidence="ECO:0000255"
FT REPEAT 627..665
FT /note="HEAT 4"
FT /evidence="ECO:0000255"
FT REPEAT 663..702
FT /note="ARM 6"
FT /evidence="ECO:0000255"
FT REPEAT 668..706
FT /note="HEAT 5"
FT /evidence="ECO:0000255"
FT REPEAT 746..785
FT /note="ARM 7"
FT /evidence="ECO:0000255"
FT REPEAT 828..867
FT /note="ARM 8"
FT /evidence="ECO:0000255"
FT REPEAT 831..870
FT /note="HEAT 6"
FT /evidence="ECO:0000255"
FT REPEAT 871..910
FT /note="ARM 9"
FT /evidence="ECO:0000255"
FT REPEAT 874..914
FT /note="HEAT 7"
FT /evidence="ECO:0000255"
FT REPEAT 912..951
FT /note="ARM 10"
FT /evidence="ECO:0000255"
FT REPEAT 916..955
FT /note="HEAT 8"
FT /evidence="ECO:0000255"
FT REPEAT 953..992
FT /note="ARM 11"
FT /evidence="ECO:0000255"
FT REPEAT 958..996
FT /note="HEAT 9"
FT /evidence="ECO:0000255"
FT REPEAT 999..1037
FT /note="HEAT 10"
FT /evidence="ECO:0000255"
FT REPEAT 1004..1031
FT /note="ARM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00259"
SQ SEQUENCE 1044 AA; 115859 MW; 74672FC2E8E65FE6 CRC64;
MGVALTRSAQ WTAAGHGAKT LEVTPLNEAI VKEIIMFVES FIYKYPQEAN YVFVEPLEWK
TNLDPSAFGS GYAVSGTTVK SEEADKNGEP LLYLSVPQIK IRSFGQLSRM LYIAKNMKLK
EAQACIEANR NPVAKILGLD YNIISEKIGN SFVSNILDKI TKDDDSESEI KMKIALQLKQ
LDLHLLNHSL KHISLEIRLN PGTVKNDIEL LKQFSGKGKQ TVLESIEYTS DYEFSNGCRA
PPWRQIKGEI CYVLVKPHDA ETLCVTCSKE GVFLNGGKTD DEGQINYERK GEIYKDLVTL
LKEKSAIFSE NMSKQEIKFS EQPQKDQPNE APKEEVAITH KASVTSRKST QEKNRINLGR
SQLTKRLEPS LNWRTSVSSK DRNTLRDTQV EKHGGKLEKS RSSVSPGRAQ LIRKSVEKIE
EIISDSSSES EEDEEQPDHR QEANADLPSE YWQIQKLVKY LKGGNQTATV IALCSMKDFN
LAQETCQLAI RDVGGLEVLI NLLETDEVKC KIGSLKILKE ISHNPQIRRN IVDLGGLPVM
VNILDSPHKS LKCLAAETIA NVAKFRRARR VVRRHGGITK LVALLDCGKH SGEPAQSSLY
ETRDVEVARC GALALWSCSK SYANKEAIRK AGGIPLLARL LKTSHENMLI PVVGTLQECA
SEENYRAAIK AERIIENLVK NLNSENEQLQ EHCAMAIYQC AEDEETRDLV RLHGGLKPLA
SLLNNTDNKE RLAAVTGAIW KCSISKENVT KFREYKAIET LVGLLTDQPE EVLVNVVGAL
GECCQEHENR VIIRRCGGIQ PLVNLLVGIN QALLVNVTKA VGACAVEPES MMIIDRLDGV
RLLWSLLKNP HPDVKASAAW ALCPCIQNAK DAGEMVRSFV GGLELVVNLL KSDNKEVLAS
VCAVITNIAK DQENLAVITD HGVVPLLSKL ANTNNDKLRR HLAETISRCC MWGRNRVAFG
EHKAVAPLVR YLKSNDTNVH RATAQALYQL SEDADNCVTM HENGAVKLLL DMVGSPDEEL
QEAAAGCISN IRRLALAIEK ARYS
