ODAD2_HUMAN
ID ODAD2_HUMAN Reviewed; 1044 AA.
AC Q5T2S8; A8K906; B7Z7I1; Q9H0C0;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Outer dynein arm-docking complex subunit 2;
DE AltName: Full=Armadillo repeat-containing protein 4;
GN Name=ODAD2 {ECO:0000312|HGNC:HGNC:25583}; Synonyms=ARMC4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Cerebellum;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 508-1044 (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [6]
RP METHYLATION [LARGE SCALE ANALYSIS] AT LYS-552, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Colon carcinoma;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
RN [7]
RP VARIANT CILD23 TRP-927, FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=23849778; DOI=10.1016/j.ajhg.2013.06.009;
RA Hjeij R., Lindstrand A., Francis R., Zariwala M.A., Liu X., Li Y.,
RA Damerla R., Dougherty G.W., Abouhamed M., Olbrich H., Loges N.T.,
RA Pennekamp P., Davis E.E., Carvalho C.M., Pehlivan D., Werner C., Raidt J.,
RA Kohler G., Haffner K., Reyes-Mugica M., Lupski J.R., Leigh M.W.,
RA Rosenfeld M., Morgan L.C., Knowles M.R., Lo C.W., Katsanis N., Omran H.;
RT "ARMC4 mutations cause primary ciliary dyskinesia with randomization of
RT left/right body asymmetry.";
RL Am. J. Hum. Genet. 93:357-367(2013).
RN [8]
RP INVOLVEMENT IN CILD23.
RX PubMed=25186273; DOI=10.1183/09031936.00052014;
RA Raidt J., Wallmeier J., Hjeij R., Onnebrink J.G., Pennekamp P., Loges N.T.,
RA Olbrich H., Haeffner K., Dougherty G.W., Omran H., Werner C.;
RT "Ciliary beat pattern and frequency in genetic variants of primary ciliary
RT dyskinesia.";
RL Eur. Respir. J. 44:1579-1588(2014).
RN [9]
RP SUBUNIT, AND FUNCTION.
RX PubMed=27486780; DOI=10.1016/j.ajhg.2016.06.014;
RA Wallmeier J., Shiratori H., Dougherty G.W., Edelbusch C., Hjeij R.,
RA Loges N.T., Menchen T., Olbrich H., Pennekamp P., Raidt J., Werner C.,
RA Minegishi K., Shinohara K., Asai Y., Takaoka K., Lee C., Griese M.,
RA Memari Y., Durbin R., Kolb-Kokocinski A., Sauer S., Wallingford J.B.,
RA Hamada H., Omran H.;
RT "TTC25 deficiency results in defects of the outer dynein arm docking
RT machinery and primary ciliary dyskinesia with left-right body asymmetry
RT randomization.";
RL Am. J. Hum. Genet. 99:460-469(2016).
CC -!- FUNCTION: Component of the outer dynein arm-docking complex (ODA-DC)
CC that mediates outer dynein arms (ODA) binding onto the doublet
CC microtubule (PubMed:27486780). Involved in mediating assembly of both
CC ODAs and their axonemal docking complex onto ciliary microtubules
CC (PubMed:23849778). {ECO:0000269|PubMed:23849778,
CC ECO:0000269|PubMed:27486780}.
CC -!- SUBUNIT: Component of the outer dynein arm-docking complex along with
CC ODAD1, ODAD3, and ODAD4. {ECO:0000269|PubMed:27486780}.
CC -!- INTERACTION:
CC Q5T2S8; P43354: NR4A2; NbExp=3; IntAct=EBI-12200605, EBI-2681738;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000269|PubMed:23849778}. Cytoplasm, cytoskeleton, cilium basal
CC body {ECO:0000269|PubMed:23849778}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5T2S8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5T2S8-2; Sequence=VSP_056695, VSP_056696;
CC -!- TISSUE SPECIFICITY: Expressed in respiratory epithelial cells (at
CC protein level). {ECO:0000269|PubMed:23849778}.
CC -!- DISEASE: Ciliary dyskinesia, primary, 23 (CILD23) [MIM:615451]: A
CC disorder characterized by abnormalities of motile cilia. Respiratory
CC infections leading to chronic inflammation and bronchiectasis are
CC recurrent, due to defects in the respiratory cilia. Patients may
CC exhibit randomization of left-right body asymmetry and situs inversus,
CC due to dysfunction of monocilia at the embryonic node. Primary ciliary
CC dyskinesia associated with situs inversus is referred to as Kartagener
CC syndrome. {ECO:0000269|PubMed:23849778, ECO:0000269|PubMed:25186273}.
CC Note=The disease is caused by variants affecting the gene represented
CC in this entry. Contrary to the wild-type protein, disease-causing
CC variant Trp-927 is unable to rescue the phenotype (randomization of
CC heart looping) of the morpholino knockdown of the orthologous protein
CC in zebrafish (PubMed:23849778). {ECO:0000269|PubMed:23849778}.
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DR EMBL; AK292521; BAF85210.1; -; mRNA.
DR EMBL; AK302048; BAH13617.1; -; mRNA.
DR EMBL; AC024606; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL390866; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL355372; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471072; EAW86050.1; -; Genomic_DNA.
DR EMBL; BC140846; AAI40847.1; -; mRNA.
DR EMBL; AL136859; CAB66793.2; -; mRNA.
DR CCDS; CCDS7157.1; -. [Q5T2S8-1]
DR RefSeq; NP_001276949.1; NM_001290020.1. [Q5T2S8-1]
DR RefSeq; NP_001276950.1; NM_001290021.1. [Q5T2S8-2]
DR RefSeq; NP_001299618.1; NM_001312689.1.
DR RefSeq; NP_060546.2; NM_018076.4. [Q5T2S8-1]
DR AlphaFoldDB; Q5T2S8; -.
DR SMR; Q5T2S8; -.
DR BioGRID; 120436; 25.
DR IntAct; Q5T2S8; 3.
DR STRING; 9606.ENSP00000306410; -.
DR GlyGen; Q5T2S8; 1 site, 2 O-linked glycans (1 site).
DR iPTMnet; Q5T2S8; -.
DR PhosphoSitePlus; Q5T2S8; -.
DR BioMuta; ARMC4; -.
DR DMDM; 74744660; -.
DR MassIVE; Q5T2S8; -.
DR MaxQB; Q5T2S8; -.
DR PaxDb; Q5T2S8; -.
DR PeptideAtlas; Q5T2S8; -.
DR PRIDE; Q5T2S8; -.
DR ProteomicsDB; 64357; -. [Q5T2S8-1]
DR ProteomicsDB; 6871; -.
DR Antibodypedia; 26109; 34 antibodies from 13 providers.
DR DNASU; 55130; -.
DR Ensembl; ENST00000305242.10; ENSP00000306410.5; ENSG00000169126.16. [Q5T2S8-1]
DR Ensembl; ENST00000672877.1; ENSP00000500120.1; ENSG00000169126.16. [Q5T2S8-2]
DR Ensembl; ENST00000673439.1; ENSP00000500782.1; ENSG00000169126.16. [Q5T2S8-1]
DR GeneID; 55130; -.
DR KEGG; hsa:55130; -.
DR MANE-Select; ENST00000305242.10; ENSP00000306410.5; NM_018076.5; NP_060546.2.
DR UCSC; uc001itz.3; human. [Q5T2S8-1]
DR CTD; 55130; -.
DR DisGeNET; 55130; -.
DR GeneCards; ODAD2; -.
DR GeneReviews; ODAD2; -.
DR HGNC; HGNC:25583; ODAD2.
DR HPA; ENSG00000169126; Group enriched (fallopian tube, testis).
DR MalaCards; ODAD2; -.
DR MIM; 615408; gene.
DR MIM; 615451; phenotype.
DR neXtProt; NX_Q5T2S8; -.
DR OpenTargets; ENSG00000169126; -.
DR Orphanet; 244; Primary ciliary dyskinesia.
DR VEuPathDB; HostDB:ENSG00000169126; -.
DR eggNOG; KOG0167; Eukaryota.
DR GeneTree; ENSGT00940000156625; -.
DR HOGENOM; CLU_011703_0_0_1; -.
DR InParanoid; Q5T2S8; -.
DR OMA; DAIARCC; -.
DR OrthoDB; 310809at2759; -.
DR PhylomeDB; Q5T2S8; -.
DR TreeFam; TF324155; -.
DR PathwayCommons; Q5T2S8; -.
DR SignaLink; Q5T2S8; -.
DR BioGRID-ORCS; 55130; 11 hits in 1069 CRISPR screens.
DR ChiTaRS; ARMC4; human.
DR GenomeRNAi; 55130; -.
DR Pharos; Q5T2S8; Tbio.
DR PRO; PR:Q5T2S8; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q5T2S8; protein.
DR Bgee; ENSG00000169126; Expressed in bronchial epithelial cell and 108 other tissues.
DR ExpressionAtlas; Q5T2S8; baseline and differential.
DR Genevisible; Q5T2S8; HS.
DR GO; GO:0005930; C:axoneme; IDA:SYSCILIA_CCNET.
DR GO; GO:0097546; C:ciliary base; IDA:MGI.
DR GO; GO:0003341; P:cilium movement; IMP:SYSCILIA_CCNET.
DR GO; GO:0007368; P:determination of left/right symmetry; IMP:SYSCILIA_CCNET.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0036158; P:outer dynein arm assembly; IMP:SYSCILIA_CCNET.
DR GO; GO:0003356; P:regulation of cilium beat frequency; IMP:SYSCILIA_CCNET.
DR GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR Gene3D; 1.25.10.10; -; 4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR Pfam; PF00514; Arm; 2.
DR SMART; SM00185; ARM; 13.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48371; SSF48371; 2.
DR PROSITE; PS50176; ARM_REPEAT; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell projection; Ciliopathy; Cilium;
KW Cilium biogenesis/degradation; Cytoplasm; Cytoskeleton;
KW Kartagener syndrome; Methylation; Primary ciliary dyskinesia;
KW Reference proteome; Repeat.
FT CHAIN 1..1044
FT /note="Outer dynein arm-docking complex subunit 2"
FT /id="PRO_0000243931"
FT REPEAT 484..523
FT /note="ARM 2"
FT /evidence="ECO:0000255"
FT REPEAT 525..564
FT /note="ARM 3"
FT /evidence="ECO:0000255"
FT REPEAT 535..577
FT /note="ARM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00259"
FT REPEAT 622..661
FT /note="ARM 4"
FT /evidence="ECO:0000255"
FT REPEAT 663..702
FT /note="ARM 5"
FT /evidence="ECO:0000255"
FT REPEAT 746..785
FT /note="ARM 6"
FT /evidence="ECO:0000255"
FT REPEAT 828..867
FT /note="ARM 7"
FT /evidence="ECO:0000255"
FT REPEAT 912..951
FT /note="ARM 8"
FT /evidence="ECO:0000255"
FT REPEAT 953..992
FT /note="ARM 9"
FT /evidence="ECO:0000255"
FT REPEAT 994..1033
FT /note="ARM 10"
FT /evidence="ECO:0000255"
FT REGION 316..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 378..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..348
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..403
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..425
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 552
FT /note="N6-methyllysine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT VAR_SEQ 1..475
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056695"
FT VAR_SEQ 1008..1044
FT /note="LLLDMVGSPDQDLQEAAAGCISNIRRLALATEKARYT -> TESRHVARLEC
FT SDNDLGSLQPPPPGFKRFSCLSLLSSWDYSFYWIWLGPLTRISRKLQLVVYPISAGWLL
FT LQRRQDTLEI (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056696"
FT VARIANT 343
FT /note="I -> T (in dbSNP:rs4405206)"
FT /id="VAR_050672"
FT VARIANT 927
FT /note="L -> W (in CILD23; no effect on subcellular
FT location, markedly reduced ciliary beat frequency and
FT amplitude or complete immotility in most, but not all,
FT respiratory cilia; dbSNP:rs587777047)"
FT /evidence="ECO:0000269|PubMed:23849778"
FT /id="VAR_070228"
FT VARIANT 935
FT /note="N -> K (in dbSNP:rs35181927)"
FT /id="VAR_033514"
FT VARIANT 1041
FT /note="A -> S (in dbSNP:rs3737184)"
FT /id="VAR_050673"
SQ SEQUENCE 1044 AA; 115679 MW; C0D869AFC3B03E9D CRC64;
MGVALRKLTQ WTAAGHGTGI LEITPLNEAI LKEIIVFVES FIYKHPQEAK FVFVEPLEWN
TSLAPSAFES GYVVSETTVK SEEVDKNGQP LLFLSVPQIK IRSFGQLSRL LLIAKTGKLK
EAQACVEANR DPIVKILGSD YNTMKENSIA LNILGKITRD DDPESEIKMK IAMLLKQLDL
HLLNHSLKHI SLEISLSPMT VKKDIELLKR FSGKGNQTVL ESIEYTSDYE FSNGCRAPPW
RQIRGEICYV LVKPHDGETL CITCSAGGVF LNGGKTDDEG DVNYERKGSI YKNLVTFLRE
KSPKFSENMS KLGISFSEDQ QKEKDQLGKA PKKEEAAALR KDISGSDKRS LEKNQINFWR
NQMTKRWEPS LNWKTTVNYK GKGSAKEIQE DKHTGKLEKP RPSVSHGRAQ LLRKSAEKIE
ETVSDSSSES EEDEEPPDHR QEASADLPSE YWQIQKLVKY LKGGNQTATV IALCSMRDFS
LAQETCQLAI RDVGGLEVLI NLLETDEVKC KIGSLKILKE ISHNPQIRQN IVDLGGLPIM
VNILDSPHKS LKCLAAETIA NVAKFKRARR VVRQHGGITK LVALLDCAHD STKPAQSSLY
EARDVEVARC GALALWSCSK SHTNKEAIRK AGGIPLLARL LKTSHENMLI PVVGTLQECA
SEENYRAAIK AERIIENLVK NLNSENEQLQ EHCAMAIYQC AEDKETRDLV RLHGGLKPLA
SLLNNTDNKE RLAAVTGAIW KCSISKENVT KFREYKAIET LVGLLTDQPE EVLVNVVGAL
GECCQERENR VIVRKCGGIQ PLVNLLVGIN QALLVNVTKA VGACAVEPES MMIIDRLDGV
RLLWSLLKNP HPDVKASAAW ALCPCIKNAK DAGEMVRSFV GGLELIVNLL KSDNKEVLAS
VCAAITNIAK DQENLAVITD HGVVPLLSKL ANTNNNKLRH HLAEAISRCC MWGRNRVAFG
EHKAVAPLVR YLKSNDTNVH RATAQALYQL SEDADNCITM HENGAVKLLL DMVGSPDQDL
QEAAAGCISN IRRLALATEK ARYT
