ODAD2_MOUSE
ID ODAD2_MOUSE Reviewed; 1037 AA.
AC B2RY50; Q9CUL6;
DT 22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Outer dynein arm-docking complex subunit 2;
DE AltName: Full=Armadillo repeat-containing protein 4;
GN Name=Odad2 {ECO:0000312|MGI:MGI:1922184}; Synonyms=Armc4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-383.
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [6]
RP FUNCTION, DEVELOPMENTAL STAGE, AND MUTAGENESIS OF MET-993.
RX PubMed=23849778; DOI=10.1016/j.ajhg.2013.06.009;
RA Hjeij R., Lindstrand A., Francis R., Zariwala M.A., Liu X., Li Y.,
RA Damerla R., Dougherty G.W., Abouhamed M., Olbrich H., Loges N.T.,
RA Pennekamp P., Davis E.E., Carvalho C.M., Pehlivan D., Werner C., Raidt J.,
RA Kohler G., Haffner K., Reyes-Mugica M., Lupski J.R., Leigh M.W.,
RA Rosenfeld M., Morgan L.C., Knowles M.R., Lo C.W., Katsanis N., Omran H.;
RT "ARMC4 mutations cause primary ciliary dyskinesia with randomization of
RT left/right body asymmetry.";
RL Am. J. Hum. Genet. 93:357-367(2013).
RN [7]
RP TISSUE SPECIFICITY.
RX PubMed=24055424; DOI=10.1016/j.gene.2013.08.080;
RA Cheng W., Ip Y.T., Xu Z.;
RT "Gudu, an Armadillo repeat-containing protein, is required for
RT spermatogenesis in Drosophila.";
RL Gene 531:294-300(2013).
CC -!- FUNCTION: Component of the outer dynein arm-docking complex (ODA-DC)
CC that mediates outer dynein arms (ODA) binding onto the doublet
CC microtubule (By similarity). Involved in mediating assembly of both
CC ODAs and their axonemal docking complex onto ciliary microtubules
CC (PubMed:23849778). {ECO:0000250|UniProtKB:E1B8W3,
CC ECO:0000269|PubMed:23849778}.
CC -!- SUBUNIT: Component of the outer dynein arm-docking complex along with
CC ODAD1, ODAD3, and ODAD4. {ECO:0000250|UniProtKB:Q5T2S8}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:Q5T2S8}. Cytoplasm, cytoskeleton, cilium basal
CC body {ECO:0000250|UniProtKB:Q5T2S8}.
CC -!- TISSUE SPECIFICITY: Highly expressed in testis. In males, also detected
CC at lower levels in lung, brain, liver and muscle. In females, detected
CC in ovary. {ECO:0000269|PubMed:24055424}.
CC -!- DEVELOPMENTAL STAGE: At 7.5 dpc, expressed in the ventral node.
CC {ECO:0000269|PubMed:23849778}.
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DR EMBL; AC139334; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC147269; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466592; EDL23026.1; -; Genomic_DNA.
DR EMBL; BC158097; AAI58098.1; -; mRNA.
DR EMBL; AK015498; BAB29870.2; -; mRNA.
DR CCDS; CCDS37729.1; -.
DR RefSeq; NP_001074862.1; NM_001081393.1.
DR RefSeq; XP_006526374.1; XM_006526311.3.
DR AlphaFoldDB; B2RY50; -.
DR SMR; B2RY50; -.
DR STRING; 10090.ENSMUSP00000080028; -.
DR iPTMnet; B2RY50; -.
DR PhosphoSitePlus; B2RY50; -.
DR MaxQB; B2RY50; -.
DR PaxDb; B2RY50; -.
DR PRIDE; B2RY50; -.
DR ProteomicsDB; 283225; -.
DR Antibodypedia; 26109; 34 antibodies from 13 providers.
DR Ensembl; ENSMUST00000081275; ENSMUSP00000080028; ENSMUSG00000061802.
DR Ensembl; ENSMUST00000234788; ENSMUSP00000157197; ENSMUSG00000061802.
DR UCSC; uc008dzq.1; mouse.
DR MGI; MGI:1922184; Odad2.
DR VEuPathDB; HostDB:ENSMUSG00000061802; -.
DR eggNOG; KOG0167; Eukaryota.
DR GeneTree; ENSGT00940000156625; -.
DR HOGENOM; CLU_011703_0_0_1; -.
DR InParanoid; B2RY50; -.
DR OMA; DAIARCC; -.
DR OrthoDB; 310809at2759; -.
DR PhylomeDB; B2RY50; -.
DR TreeFam; TF324155; -.
DR BioGRID-ORCS; 74934; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Armc4; mouse.
DR PRO; PR:B2RY50; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; B2RY50; protein.
DR Bgee; ENSMUSG00000061802; Expressed in otolith organ and 40 other tissues.
DR ExpressionAtlas; B2RY50; baseline and differential.
DR Genevisible; B2RY50; MM.
DR GO; GO:0005930; C:axoneme; ISO:MGI.
DR GO; GO:0097546; C:ciliary base; ISO:MGI.
DR GO; GO:0003341; P:cilium movement; IMP:MGI.
DR GO; GO:0007368; P:determination of left/right symmetry; IMP:MGI.
DR GO; GO:0007507; P:heart development; IMP:MGI.
DR GO; GO:0036158; P:outer dynein arm assembly; IMP:MGI.
DR GO; GO:0003356; P:regulation of cilium beat frequency; ISO:MGI.
DR GO; GO:0021591; P:ventricular system development; IMP:MGI.
DR Gene3D; 1.25.10.10; -; 4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR Pfam; PF00514; Arm; 1.
DR SMART; SM00185; ARM; 13.
DR SUPFAM; SSF48371; SSF48371; 2.
DR PROSITE; PS50176; ARM_REPEAT; 3.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Cilium biogenesis/degradation; Cytoplasm;
KW Cytoskeleton; Methylation; Reference proteome; Repeat.
FT CHAIN 1..1037
FT /note="Outer dynein arm-docking complex subunit 2"
FT /id="PRO_0000425145"
FT REPEAT 477..516
FT /note="ARM 2"
FT /evidence="ECO:0000255"
FT REPEAT 518..557
FT /note="ARM 3"
FT /evidence="ECO:0000255"
FT REPEAT 528..570
FT /note="ARM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00259"
FT REPEAT 615..654
FT /note="ARM 4"
FT /evidence="ECO:0000255"
FT REPEAT 656..695
FT /note="ARM 5"
FT /evidence="ECO:0000255"
FT REPEAT 739..778
FT /note="ARM 6"
FT /evidence="ECO:0000255"
FT REPEAT 821..860
FT /note="ARM 7"
FT /evidence="ECO:0000255"
FT REPEAT 864..903
FT /note="ARM 8"
FT /evidence="ECO:0000255"
FT REPEAT 905..944
FT /note="ARM 9"
FT /evidence="ECO:0000255"
FT REPEAT 946..985
FT /note="ARM 10"
FT /evidence="ECO:0000255"
FT REGION 316..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..390
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..418
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 545
FT /note="N6-methyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q5T2S8"
FT MUTAGEN 993
FT /note="M->K: In Aotea; randomization of laterality. Mutants
FT exhibit a range of cardiovascular anomalies, including
FT right aortic arch, perimembranous and muscular ventricular
FT septal defects, ventricular non-compaction and anomalous
FT venous return. Respiratory cilia are either immotile or
FT have slow dyskinetic motion compared to wild-type animals.
FT Tracheal airway cilia show a marked reduction in outer
FT dynein arms. In the brain, fluid flow is generated by
FT ependymal cilia, but is slower than in wild-type animals.
FT Aotea mutants develop hydrocephalus at 3 to 4 weeks of age
FT and die."
FT /evidence="ECO:0000269|PubMed:23849778"
SQ SEQUENCE 1037 AA; 115266 MW; 5057F8CFD7368D04 CRC64;
MGVALTRLAQ WTAAGYETGT LEITPLNESI LNEITKFVES FSYKYPQEAK FVFVEPLEWK
TYLEPSAFEL GYVVSATTAE SEETGKDGQP LLFLSVPYIK VRSFGQLSQL LSIATDSKLQ
EAQACIEANR DPVVKILGPD YNEMKEDPTR LTLLDTIIKD KETYMKRKVA ILLKQLDLHL
LNHSLKYISL EISLNPGTFK KDIELLKRFS GKGEQTVLES IEYTSDYEFS NGCRAPPWRQ
IQGEICYVLV KPHDMETLCL TCSTEGVFLN GGKTEEEGEI NYERKGEIYK DLVTCLKDKS
PVFSENMSKH EIRFTEEQQK DNQIFEKPKT EDGHSSVAGS EKSKIEKISF GKSPMTKRLE
PSLNWRVTVD YKDHKSSIKD SQEEKQGKLE KSSSVSVAPS RAQSHRKGGE KVEETVSESS
SESEEDEEPP DHRQEANADL PSEYWQIQKL VKYLKGGNQT ATVIALCSMR DFNLAQETCQ
LAIRDVGGLE VLINLLDTDE VKCKIGSLKI LKEISHNPQI RRNIVDLGGL PIMVNILDSP
HKSLKCLSAE TIANVAKFKR ARRAVRQHGG ITKLVALLDC GQNSTEPTQP SLYETRDVEV
ARCGALALWS CSKSHSNKEA IRKAGGIPLL ARLLKTSHEN MLIPVVGTLQ ECASEENYRA
AIKAERIIEN LVKNLNSENE QLQEHCAMAI YQCAEDEETR DLVRLHGGLK PLASLLNNTD
NKERLAAVTG AIWKCSISKE NVIKFREYKA IETLVGLLTD QPEEVLVNVV GALGECCQEY
ENRVLVRKCG GIQPLVNLLV GINQALLVNV TKAVGACAVE PESMAIIDRL DGVRLLWSLL
KNPHPDVKAS AAWALCPCIE NAKDAGEMVR SFVGGLELVV NLLKSDNKEV LASVCAAITN
IAKDQENLAV ITDHGVVPLL SKLANTNNDK LRRHLAEAIS RCCMWGRNRV AFGEHKAVAP
LVRYLKSNDT NVHRATAQAL YQLSEDADNC ITMHENGAVK LLLDMVGSPD QDLQEAAAGC
ISNIRRLALA TEKARYN
