ODAD3_BOVIN
ID ODAD3_BOVIN Reviewed; 621 AA.
AC A7MBH5;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 1.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=Outer dynein arm-docking complex subunit 3;
DE AltName: Full=Coiled-coil domain-containing protein 151;
GN Name=ODAD3; Synonyms=CCDC151;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0007744|PDB:7RRO}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS), SUBUNIT, INTERACTION
RP WITH PIERCE1 AND PIERCE2, SUBCELLULAR LOCATION, FUNCTION, AND TISSUE
RP SPECIFICITY.
RX PubMed=34715025; DOI=10.1016/j.cell.2021.10.007;
RA Gui M., Farley H., Anujan P., Anderson J.R., Maxwell D.W., Whitchurch J.B.,
RA Botsch J.J., Qiu T., Meleppattu S., Singh S.K., Zhang Q., Thompson J.,
RA Lucas J.S., Bingle C.D., Norris D.P., Roy S., Brown A.;
RT "De novo identification of mammalian ciliary motility proteins using cryo-
RT EM.";
RL Cell 184:5791-5806.e19(2021).
CC -!- FUNCTION: Component of the outer dynein arm-docking complex (ODA-DC)
CC that mediates outer dynein arms (ODA) binding onto the doublet
CC microtubule. Involved in mediating assembly of both ODAs and their
CC axonemal docking complex onto ciliary microtubules.
CC {ECO:0000269|PubMed:34715025}.
CC -!- SUBUNIT: Component of the outer dynein arm-docking complex along with
CC ODAD1, ODAD2, ODAD4 and CLXN. Interacts with ODAD1 (PubMed:34715025).
CC Interacts with PIERCE1 and PIERCE2; the interactions link the outer
CC dynein arms docking complex (ODA-DC) to the internal microtubule inner
CC proteins (MIP) in cilium axoneme (PubMed:34715025).
CC {ECO:0000269|PubMed:34715025}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC {ECO:0000250|UniProtKB:Q8BSN3}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome, centriole
CC {ECO:0000250|UniProtKB:Q8BSN3}. Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000269|PubMed:34715025}.
CC -!- TISSUE SPECIFICITY: Expressed in trachea multiciliated cells.
CC {ECO:0000269|PubMed:34715025}.
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DR EMBL; BC151560; AAI51561.1; -; mRNA.
DR RefSeq; NP_001095517.1; NM_001102047.2.
DR PDB; 7RRO; EM; 3.40 A; H4/H5/H6=1-621.
DR PDBsum; 7RRO; -.
DR AlphaFoldDB; A7MBH5; -.
DR SMR; A7MBH5; -.
DR STRING; 9913.ENSBTAP00000010785; -.
DR PaxDb; A7MBH5; -.
DR Ensembl; ENSBTAT00000010785; ENSBTAP00000010785; ENSBTAG00000008201.
DR GeneID; 517994; -.
DR KEGG; bta:517994; -.
DR CTD; 115948; -.
DR VEuPathDB; HostDB:ENSBTAG00000008201; -.
DR VGNC; VGNC:26856; ODAD3.
DR eggNOG; ENOG502QR7A; Eukaryota.
DR GeneTree; ENSGT00940000153116; -.
DR HOGENOM; CLU_033878_1_0_1; -.
DR InParanoid; A7MBH5; -.
DR OMA; QPMPVCY; -.
DR OrthoDB; 969618at2759; -.
DR TreeFam; TF324955; -.
DR Proteomes; UP000009136; Chromosome 7.
DR Bgee; ENSBTAG00000008201; Expressed in semen and 78 other tissues.
DR GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR GO; GO:0035253; C:ciliary rootlet; IBA:GO_Central.
DR GO; GO:0097542; C:ciliary tip; IBA:GO_Central.
DR GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0120228; C:outer dynein arm docking complex; IDA:UniProtKB.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0090660; P:cerebrospinal fluid circulation; IEA:Ensembl.
DR GO; GO:0003341; P:cilium movement; IDA:UniProtKB.
DR GO; GO:0061371; P:determination of heart left/right asymmetry; IEA:Ensembl.
DR GO; GO:0060287; P:epithelial cilium movement involved in determination of left/right asymmetry; IEA:Ensembl.
DR GO; GO:0030317; P:flagellated sperm motility; IEA:Ensembl.
DR GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
DR GO; GO:0036158; P:outer dynein arm assembly; IDA:UniProtKB.
DR GO; GO:1902017; P:regulation of cilium assembly; ISS:UniProtKB.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR InterPro; IPR033192; ODAD3.
DR PANTHER; PTHR46518; PTHR46518; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell projection; Cilium biogenesis/degradation; Coiled coil;
KW Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..621
FT /note="Outer dynein arm-docking complex subunit 3"
FT /id="PRO_0000321525"
FT REGION 484..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 61..325
FT /evidence="ECO:0000255"
FT COILED 386..470
FT /evidence="ECO:0000255"
FT COMPBIAS 492..506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 621 AA; 72044 MW; 3A1411A61B7BBA5A CRC64;
MTSPLCWAAA SNAMPSQDQI STPSKVKATQ VQLKPYRSRG KGLVPVWHSL HSKAGPLHAS
EGKSAVNMQV AELQRKIQLL EGDRKAFYES TQWNIKKNQE TINQLREETR VLQLQLTALL
QGDEKVVQAV IREWKSEKPY LKNRTGQQAL EHLDYRLNEK VKQLNALRHQ LGLRQKWLEE
LQLQHSLREL EIAEAQDSNT EVAKTMRNLE NRLEKARMKA EEAEHITSVY LQLKAYLQEE
SLHLGNRLDF MEAEVVRTKH ELEELHLVNQ EALNARDIAK NQLQYLEETV FRERKKRERY
LTECKKRAEE KKLQNERMER KTQREHVLLQ SDDTLQDSMY SKEEELKRRW SMYQMEVLFG
KVKDATGVAE THAVVRRFLA QGDTFTQLEM LKSENEQTLL RLKQEKQRLQ QELEDLKYSG
EALLVSEQKR QAELQGRLKM EEQRRADAQN QLDRTMRALQ ITKEGLEHLA GKLNHIVVAG
PTYEEGSPGA SLDTKGSATP QPQETGRSVG KMDPKVDDYL PNLLGLVEEK LLKLHSQLEN
HNVPEMLRHI VDLEFYATLE GKLPSYNTRI ALPVAGHKDK FFDEEESEED DSDVVTRAAL
KMRSQKLIES RSKRRGRSRR S
