ODAD4_BOVIN
ID ODAD4_BOVIN Reviewed; 683 AA.
AC A5PK42; F1MKD0;
DT 03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Outer dynein arm-docking complex subunit 4;
DE AltName: Full=Tetratricopeptide repeat protein 25;
DE Short=TPR repeat protein 25;
GN Name=ODAD4 {ECO:0000312|VGNC:VGNC:36464};
GN Synonyms=TTC25 {ECO:0000303|PubMed:34715025};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000312|EMBL:AAI42348.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford;
RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT "A whole-genome assembly of the domestic cow, Bos taurus.";
RL Genome Biol. 10:R42.01-R42.10(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0007744|PDB:7RRO}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS), SUBUNIT, FUNCTION,
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=34715025; DOI=10.1016/j.cell.2021.10.007;
RA Gui M., Farley H., Anujan P., Anderson J.R., Maxwell D.W., Whitchurch J.B.,
RA Botsch J.J., Qiu T., Meleppattu S., Singh S.K., Zhang Q., Thompson J.,
RA Lucas J.S., Bingle C.D., Norris D.P., Roy S., Brown A.;
RT "De novo identification of mammalian ciliary motility proteins using cryo-
RT EM.";
RL Cell 184:5791-5806.e19(2021).
CC -!- FUNCTION: Component of the outer dynein arm-docking complex (ODA-DC)
CC that mediates outer dynein arms (ODA) binding onto the doublet
CC microtubule. Plays an essential role for the assembly of ODA-DC and for
CC the docking of ODA in ciliary axoneme. {ECO:0000269|PubMed:34715025}.
CC -!- SUBUNIT: Component of the outer dynein arm-docking complex along with
CC ODAD1, ODAD2 and ODAD3. Interacts with ODAD1; this interaction may
CC facilitate the recruitment and/or attachment of outer dynein arm
CC docking complex proteins, including ODAD1, ODAD3 and ODAD2, to ciliary
CC axonemes (PubMed:34715025). Interacts with components of the IFT
CC complex A, including IFT140, TTC21B/IFT139 and WDR19/IFT144, and the
CC IFT complex B, including IFT46, IFT52 and IFT57 (By similarity).
CC {ECO:0000250|UniProtKB:Q96NG3, ECO:0000269|PubMed:34715025}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000269|PubMed:34715025}.
CC -!- TISSUE SPECIFICITY: Expressed in trachea multiciliated cells.
CC {ECO:0000269|PubMed:34715025}.
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DR EMBL; BC142347; AAI42348.1; -; mRNA.
DR RefSeq; NP_001096778.1; NM_001103308.2.
DR PDB; 7RRO; EM; 3.40 A; I1/I2=1-683.
DR PDBsum; 7RRO; -.
DR SMR; A5PK42; -.
DR STRING; 9913.ENSBTAP00000018203; -.
DR Ensembl; ENSBTAT00000018203.6; ENSBTAP00000018203.5; ENSBTAG00000013698.6.
DR GeneID; 788831; -.
DR KEGG; bta:788831; -.
DR CTD; 83538; -.
DR VEuPathDB; HostDB:ENSBTAG00000013698; -.
DR VGNC; VGNC:36464; ODAD4.
DR eggNOG; KOG1124; Eukaryota.
DR GeneTree; ENSGT00390000007911; -.
DR HOGENOM; CLU_023648_2_1_1; -.
DR OMA; WDHIEDE; -.
DR OrthoDB; 1417967at2759; -.
DR TreeFam; TF323661; -.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000013698; Expressed in oviduct epithelium and 62 other tissues.
DR GO; GO:0097728; C:9+0 motile cilium; IEA:Ensembl.
DR GO; GO:0097729; C:9+2 motile cilium; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0120228; C:outer dynein arm docking complex; ISS:UniProtKB.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0090660; P:cerebrospinal fluid circulation; IEA:Ensembl.
DR GO; GO:0003341; P:cilium movement; IDA:UniProtKB.
DR GO; GO:0060287; P:epithelial cilium movement involved in determination of left/right asymmetry; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0030324; P:lung development; IEA:Ensembl.
DR GO; GO:0120197; P:mucociliary clearance; IEA:Ensembl.
DR GO; GO:0036158; P:outer dynein arm assembly; IDA:UniProtKB.
DR GO; GO:0120229; P:protein localization to motile cilium; IEA:Ensembl.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR040111; ODAD4.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR23040; PTHR23040; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 7.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50005; TPR; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell projection; Cytoplasm; Cytoskeleton; Reference proteome;
KW Repeat; TPR repeat.
FT CHAIN 1..683
FT /note="Outer dynein arm-docking complex subunit 4"
FT /id="PRO_0000456155"
FT REPEAT 13..46
FT /note="TPR 1"
FT /evidence="ECO:0000255, ECO:0000255|PROSITE-
FT ProRule:PRU00339"
FT REPEAT 47..80
FT /note="TPR 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00339"
FT REPEAT 48..80
FT /note="TPR 8"
FT /evidence="ECO:0000255"
FT REPEAT 81..114
FT /note="TPR 3"
FT /evidence="ECO:0000255, ECO:0000255|PROSITE-
FT ProRule:PRU00339"
FT REPEAT 275..311
FT /note="TPR 10"
FT /evidence="ECO:0000255"
FT REPEAT 320..353
FT /note="TPR 4"
FT /evidence="ECO:0000255, ECO:0000255|PROSITE-
FT ProRule:PRU00339"
FT REPEAT 360..393
FT /note="TPR 5"
FT /evidence="ECO:0000255, ECO:0000255|PROSITE-
FT ProRule:PRU00339"
FT REPEAT 397..430
FT /note="TPR 13"
FT /evidence="ECO:0000255"
FT REPEAT 437..470
FT /note="TPR 6"
FT /evidence="ECO:0000255, ECO:0000255|PROSITE-
FT ProRule:PRU00339"
FT REPEAT 592..625
FT /note="TPR 15"
FT /evidence="ECO:0000255"
SQ SEQUENCE 683 AA; 78368 MW; DA45F3AE671DB9B5 CRC64;
MADPENEVLR STFPSYMAEG ERLYLCGEFA KAAHSFSNAL HLQSGDKNCL VARSKCFLKM
GELEKSLEDA EASLQGDPTF CKGILQKAET LYTMGDFEFA LVFYHRGYKL RPDREFKVGI
QKAQEAINNS VGSPSSIKLE NKGDLSFLSK QAESMRAQQK PHPVRQLIHH PKRESKRKGS
LKSEKIVRQL LGELYVDKEY LEKLLLDEDL IKGTIKHGLT VEDLIMTGIN YLETRSDFWR
QQKPIYARER DRKLMQEKWL RDRKRRPSQT ARYILKSLED IDMLLTSGSA EGSLQKAEKV
LKKVLEWNKE EVPNKDELVG NLYSCIGNAQ IELGQMVAAL QSHRKDLEIA KEYDLPDAKS
RALDNIGRVF ARVGKFQQAI DTWEEKIPLA KTTLEKTWLF HEIGRCYLEL DQAWEAQSYG
EKSQQCAEEE GDMEWQLNAS VLVAQAQVKL RDFESAVNNF EKALERAKLV HNNEAQQAII
NALDDANKGI IEELKKTNYR EILKEKKEKE NATMLDGQTR TAKEKETRKT KDEPEKVMKQ
WVQEQTEKQL EGVLSKETLG VTARQPEQRQ REDPEKASWR KELGAKERGP GDTAKGQFGE
AGRTEQNREE TREIYRRPSE LDQNLSDESS PRESEGLEKR LSKTDGGELE ALGKTESGEI
KEMEITENSE KIEKDEKEDE PIE
