ODAD4_DANRE
ID ODAD4_DANRE Reviewed; 486 AA.
AC Q7ZU45; F1RBQ8;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2021, sequence version 2.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Outer dynein arm-docking complex subunit 4;
DE AltName: Full=Tetratricopeptide repeat protein 25;
DE Short=TPR repeat protein 25;
GN Name=odad4; Synonyms=ttc25;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP DISRUPTION PHENOTYPE.
RX PubMed=25860617; DOI=10.1371/journal.pone.0124378;
RA Xu Y., Cao J., Huang S., Feng D., Zhang W., Zhu X., Yan X.;
RT "Characterization of tetratricopeptide repeat-containing proteins critical
RT for cilia formation and function.";
RL PLoS ONE 10:E0124378-E0124378(2015).
CC -!- FUNCTION: Component of the outer dynein arm-docking complex (ODA-DC)
CC that mediates outer dynein arms (ODA) binding onto the doublet
CC microtubule. Plays an essential role for the assembly of ODA-DC and in
CC the docking of ODA in ciliary axoneme. {ECO:0000250|UniProtKB:Q96NG3}.
CC -!- SUBUNIT: Component of the outer dynein arm-docking complex along with
CC ODAD1, ODAD2 and ODAD3. {ECO:0000250|UniProtKB:Q96NG3}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:Q96NG3}.
CC -!- DISRUPTION PHENOTYPE: Morpholino knockdown of the protein causes severe
CC curvature of the body at 72 hpf. Morphants also exhibit hydrocephalus,
CC abnormal otoliths and disturbed left-right asymmetry patterning. Some
CC animals (17%) tend to develop pronephric cysts. At the 7-somite stage,
CC cilia number and length are reduced in the Kupffer's vesicle. At 60
CC hpf, cilia motility is markedly impaired in the pronephric duct.
CC {ECO:0000269|PubMed:25860617}.
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DR EMBL; BX901973; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC051126; AAH51126.1; -; mRNA.
DR RefSeq; NP_956610.1; NM_200316.1.
DR AlphaFoldDB; Q7ZU45; -.
DR SMR; Q7ZU45; -.
DR STRING; 7955.ENSDARP00000075390; -.
DR PaxDb; Q7ZU45; -.
DR PRIDE; Q7ZU45; -.
DR Ensembl; ENSDART00000080946; ENSDARP00000075390; ENSDARG00000058140.
DR GeneID; 393286; -.
DR KEGG; dre:393286; -.
DR CTD; 83538; -.
DR ZFIN; ZDB-GENE-040426-995; odad4.
DR eggNOG; KOG1124; Eukaryota.
DR GeneTree; ENSGT00390000007911; -.
DR HOGENOM; CLU_023648_2_0_1; -.
DR InParanoid; Q7ZU45; -.
DR OMA; WDHIEDE; -.
DR OrthoDB; 1417967at2759; -.
DR PhylomeDB; Q7ZU45; -.
DR TreeFam; TF323661; -.
DR PRO; PR:Q7ZU45; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 3.
DR Bgee; ENSDARG00000058140; Expressed in testis and 28 other tissues.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0060271; P:cilium assembly; IMP:ZFIN.
DR GO; GO:0003341; P:cilium movement; ISS:UniProtKB.
DR GO; GO:0061371; P:determination of heart left/right asymmetry; IMP:ZFIN.
DR GO; GO:0032474; P:otolith morphogenesis; IMP:ZFIN.
DR GO; GO:0036158; P:outer dynein arm assembly; ISS:UniProtKB.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR040111; ODAD4.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR23040; PTHR23040; 1.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS50005; TPR; 7.
DR PROSITE; PS50293; TPR_REGION; 2.
PE 2: Evidence at transcript level;
KW Cell projection; Cytoplasm; Cytoskeleton; Reference proteome; Repeat;
KW TPR repeat.
FT CHAIN 1..486
FT /note="Outer dynein arm-docking complex subunit 4"
FT /id="PRO_0000284509"
FT REPEAT 14..47
FT /note="TPR 1"
FT /evidence="ECO:0000255"
FT REPEAT 49..81
FT /note="TPR 2"
FT /evidence="ECO:0000255"
FT REPEAT 82..115
FT /note="TPR 3"
FT /evidence="ECO:0000255"
FT REPEAT 314..347
FT /note="TPR 4"
FT /evidence="ECO:0000255"
FT REPEAT 354..387
FT /note="TPR 5"
FT /evidence="ECO:0000255"
FT REPEAT 391..424
FT /note="TPR 6"
FT /evidence="ECO:0000255"
FT REPEAT 431..464
FT /note="TPR 7"
FT /evidence="ECO:0000255"
FT REGION 153..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 47
FT /note="D -> N (in Ref. 2; AAH51126)"
FT CONFLICT 478
FT /note="C -> R (in Ref. 2; AAH51126)"
SQ SEQUENCE 486 AA; 55528 MW; 6385CE75E17E4EDD CRC64;
MFDNEEGQGP KSTFTTYMAE GDQLFQRGEY VKAVESFTTA LTLQPDDKNC LVSRSRCYVK
LGDAENALKD AESSLKDNKN YFKGLYQKAE ALYTMGDFEF ALVYYHRGHK LRPELQEFRL
GIQKAQEAID NSVGSPSSVK LVNKGDLSFF HNGVHPQNLN PSNKKESKKH SKKTDKGEKT
AKQLLGELYS DREYLKKLLQ DEDLVKCKIR SGERVQDLIV GSISYLDTRM AFWQQQKPIY
ARQRDRKLMQ QQWSKVLHKP PSDPTRYVLS SLEEIDTALS AGYTESGLNK ARELMKVVKD
WSEDALPNKN EVLGNLHSYI GNALMDLGNM DRALHHHEKD LELAKKCDLT DSKSRALDNI
GRVYARIGKF QQAIEVWEKK LPLACGGLEK AWLFHEIGRC YLELKRYMEA RDYGSRSLMA
ADDISDEKWQ LNASVLMAQA ELKLSNYKAS VLHFERALER AKLLQDDSAS EAIQKALCEA
RLRVTQ
