ODAPH_RAT
ID ODAPH_RAT Reviewed; 127 AA.
AC A0A0G2K6Z9;
DT 22-NOV-2017, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2015, sequence version 1.
DT 03-AUG-2022, entry version 24.
DE RecName: Full=Odontogenesis-associated phosphoprotein;
DE Flags: Precursor;
GN Name=Odaph {ECO:0000250|UniProtKB:Q17RF5};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=22901946; DOI=10.1016/j.ajhg.2012.07.020;
RA Parry D.A., Brookes S.J., Logan C.V., Poulter J.A., El-Sayed W.,
RA Al-Bahlani S., Al Harasi S., Sayed J., Raif el M., Shore R.C., Dashash M.,
RA Barron M., Morgan J.E., Carr I.M., Taylor G.R., Johnson C.A., Aldred M.J.,
RA Dixon M.J., Wright J.T., Kirkham J., Inglehearn C.F., Mighell A.J.;
RT "Mutations in C4orf26, encoding a peptide with in vitro hydroxyapatite
RT crystal nucleation and growth activity, cause amelogenesis imperfecta.";
RL Am. J. Hum. Genet. 91:565-571(2012).
CC -!- FUNCTION: May promote nucleation of hydroxyapatite.
CC {ECO:0000250|UniProtKB:Q17RF5}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q17RF5}.
CC -!- TISSUE SPECIFICITY: Expressed in enamel organs and not expressed in the
CC heart, kidney, or spleen. {ECO:0000269|PubMed:22901946}.
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DR EMBL; AC136013; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0G2K6Z9; -.
DR RGD; 6489816; Odaph.
DR VEuPathDB; HostDB:ENSRNOG00000059582; -.
DR OMA; RVHIRFP; -.
DR PRO; PR:A0A0G2K6Z9; -.
DR Proteomes; UP000002494; Chromosome 14.
DR Bgee; ENSRNOG00000059582; Expressed in skeletal muscle tissue and 13 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0070169; P:positive regulation of biomineral tissue development; ISS:UniProtKB.
DR GO; GO:0070175; P:positive regulation of enamel mineralization; ISS:UniProtKB.
DR InterPro; IPR031706; ODAPH.
DR PANTHER; PTHR40376; PTHR40376; 1.
DR Pfam; PF15848; ODAPH; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..127
FT /note="Odontogenesis-associated phosphoprotein"
FT /evidence="ECO:0000255"
FT /id="PRO_0000442288"
SQ SEQUENCE 127 AA; 14833 MW; F2005E1DB16CF357 CRC64;
MAPGFHFSWL LVSWLVVTTV KGQDVMTPPG SQNNVNPTDC QIITLTPPPT TRNQLTRAQP
VTRTPTFYFP PRRPGFYPRF PNIPFFPPNN RRFQLWPFYP PRGRLIPWRF FLGRRQLQSS
SSEESLE
