ODC_PONAB
ID ODC_PONAB Reviewed; 299 AA.
AC Q5RFB7;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Mitochondrial 2-oxodicarboxylate carrier;
DE AltName: Full=Solute carrier family 25 member 21;
GN Name=SLC25A21; Synonyms=ODC;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transports dicarboxylates across the inner membranes of
CC mitochondria by a counter-exchange mechanism. Can transport 2-
CC oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate),
CC glutarate, and to a lesser extent, pimelate (heptanedioate), 2-
CC oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate),
CC oxaloacetate, and citrate. Plays a central role in catabolism of
CC lysine, hydroxylysine, and tryptophan, by transporting common
CC metabolite intermediates (such as 2-oxoadipate) into the mitochondria,
CC where it is converted into acetyl-CoA and can enter the citric acid
CC (TCA) cycle. {ECO:0000250|UniProtKB:Q9BQT8}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoadipate(in) + 2-oxoglutarate(out) = 2-oxoadipate(out) +
CC 2-oxoglutarate(in); Xref=Rhea:RHEA:71739, ChEBI:CHEBI:16810,
CC ChEBI:CHEBI:57499; Evidence={ECO:0000250|UniProtKB:Q9BQT8};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate(out) + hexanedioate(in) = 2-oxoglutarate(in) +
CC hexanedioate(out); Xref=Rhea:RHEA:71743, ChEBI:CHEBI:16810,
CC ChEBI:CHEBI:17128; Evidence={ECO:0000250|UniProtKB:Q9BQT8};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate(out) + L-2-aminoadipate(in) = 2-
CC oxoglutarate(in) + L-2-aminoadipate(out); Xref=Rhea:RHEA:71747,
CC ChEBI:CHEBI:16810, ChEBI:CHEBI:58672;
CC Evidence={ECO:0000250|UniProtKB:Q9BQT8};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate(out) + glutarate(in) = 2-oxoglutarate(in) +
CC glutarate(out); Xref=Rhea:RHEA:71751, ChEBI:CHEBI:16810,
CC ChEBI:CHEBI:30921; Evidence={ECO:0000250|UniProtKB:Q9BQT8};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate(out) + 2-oxoheptanedioate(in) = 2-
CC oxoglutarate(in) + 2-oxoheptanedioate(out); Xref=Rhea:RHEA:71755,
CC ChEBI:CHEBI:16810, ChEBI:CHEBI:72701;
CC Evidence={ECO:0000250|UniProtKB:Q9BQT8};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate(out) + heptanedioate(in) = 2-oxoglutarate(in) +
CC heptanedioate(out); Xref=Rhea:RHEA:71759, ChEBI:CHEBI:16810,
CC ChEBI:CHEBI:36165; Evidence={ECO:0000250|UniProtKB:Q9BQT8};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate(out) + citrate(in) = 2-oxoglutarate(in) +
CC citrate(out); Xref=Rhea:RHEA:71763, ChEBI:CHEBI:16810,
CC ChEBI:CHEBI:16947; Evidence={ECO:0000250|UniProtKB:Q9BQT8};
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; CR857243; CAH89540.1; -; mRNA.
DR RefSeq; NP_001124669.1; NM_001131197.1.
DR AlphaFoldDB; Q5RFB7; -.
DR SMR; Q5RFB7; -.
DR STRING; 9601.ENSPPYP00000006539; -.
DR Ensembl; ENSPPYT00000033794; ENSPPYP00000024530; ENSPPYG00000005756.
DR GeneID; 100171514; -.
DR KEGG; pon:100171514; -.
DR CTD; 89874; -.
DR eggNOG; KOG0754; Eukaryota.
DR GeneTree; ENSGT00730000111119; -.
DR InParanoid; Q5RFB7; -.
DR OMA; MLLVFDY; -.
DR OrthoDB; 1236425at2759; -.
DR TreeFam; TF314035; -.
DR Proteomes; UP000001595; Chromosome 14.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.50.40.10; -; 2.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Antiport; Lipid transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..299
FT /note="Mitochondrial 2-oxodicarboxylate carrier"
FT /id="PRO_0000090646"
FT TRANSMEM 17..37
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..89
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 11..100
FT /note="Solcar 1"
FT REPEAT 107..196
FT /note="Solcar 2"
FT REPEAT 205..294
FT /note="Solcar 3"
SQ SEQUENCE 299 AA; 33286 MW; 5BED9506E8F955D9 CRC64;
MSAKPEVGLV REASRQIVAG GSAGLVEICL MHPLDVVKTR FQIQRCATDP NSYKSLVDSF
RMIFQTERLF GFYKGILPPI LAETPKRAVK FFTFEQYKKL LGYVSLSPAL TFTIAGLGSG
LTEAIVVNPF EVVKVGLQAN RNTFAKQPST VGYARQIIKK EGWGLQGLNK GLTATLGRHG
VFNMVYFGFY YNVKNMIPVN KDPTLEFLRK FGIGLLSGTI ASVINIPFDV AKSRIQGPQP
VPGEIKYRTC FKTMATVYQE EGILALYKGL LPKIMRLGPG GAVMLLVYEY TYSWLQENW
