ODC_SCHPO
ID ODC_SCHPO Reviewed; 298 AA.
AC Q9P3T7;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 119.
DE RecName: Full=Probable mitochondrial 2-oxodicarboxylate carrier;
GN ORFNames=SPAC328.09;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Transports C5-C7 oxodicarboxylates across the inner membranes
CC of mitochondria. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; CU329670; CAB96004.1; -; Genomic_DNA.
DR RefSeq; NP_594211.1; NM_001019634.2.
DR AlphaFoldDB; Q9P3T7; -.
DR SMR; Q9P3T7; -.
DR STRING; 4896.SPAC328.09.1; -.
DR iPTMnet; Q9P3T7; -.
DR MaxQB; Q9P3T7; -.
DR PaxDb; Q9P3T7; -.
DR EnsemblFungi; SPAC328.09.1; SPAC328.09.1:pep; SPAC328.09.
DR GeneID; 2543171; -.
DR KEGG; spo:SPAC328.09; -.
DR PomBase; SPAC328.09; -.
DR VEuPathDB; FungiDB:SPAC328.09; -.
DR eggNOG; KOG0754; Eukaryota.
DR HOGENOM; CLU_015166_5_2_1; -.
DR InParanoid; Q9P3T7; -.
DR OMA; MLLVFDY; -.
DR PhylomeDB; Q9P3T7; -.
DR Reactome; R-SPO-428643; Organic anion transporters.
DR PRO; PR:Q9P3T7; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:PomBase.
DR GO; GO:0015139; F:alpha-ketoglutarate transmembrane transporter activity; ISS:PomBase.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:1990551; P:mitochondrial 2-oxoadipate transmembrane transport; ISS:PomBase.
DR GO; GO:1990550; P:mitochondrial alpha-ketoglutarate transmembrane transport; ISS:PomBase.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..298
FT /note="Probable mitochondrial 2-oxodicarboxylate carrier"
FT /id="PRO_0000310803"
FT TRANSMEM 6..26
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..81
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..287
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 6..92
FT /note="Solcar 1"
FT REPEAT 102..188
FT /note="Solcar 2"
FT REPEAT 197..287
FT /note="Solcar 3"
SQ SEQUENCE 298 AA; 33100 MW; D6ADC939BA1F6F9A CRC64;
MPHDNIPFPV TFAAGAVAGI SEVLTLYPLD VVKTRMQLSV GKSDYNGTFD CLKKIVKNEG
PHRLYRGILP PILMEAPKRA LKFASNDTYS KLWRKVFKRK DSSPALSILT GSCAGFTETF
VVVPFELMKI RLQDVKNASK YNGTVDCFTK IVKQERILAL YNGFEATMWR HVVWNAGYFG
VIQKIRNSLT PASSRIGEIR NNLIAGTIGG IFGTFLSTPF DVIKSRIQTV PRIAGQVPKY
NWAYPALVTV AREEGFTALY KGFVPKVLRL GPGGGILLVV FNSVIEFYKR CLVHNASA
