ID   ODD1_CAEEL              Reviewed;         242 AA.
AC   P41995;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   16-JAN-2004, sequence version 2.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=Protein odd-skipped-related 1 {ECO:0000305};
GN   Name=odd-1 {ECO:0000312|WormBase:B0280.4};
GN   ORFNames=B0280.4 {ECO:0000312|WormBase:B0280.4};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX   PubMed=14648222; DOI=10.1007/s00427-003-0369-x;
RA   Buckley M.S., Chau J., Hoppe P.E., Coulter D.E.;
RT   "Odd-skipped homologs function during gut development in C. elegans.";
RL   Dev. Genes Evol. 214:10-18(2004).
RN   [3]
RP   FUNCTION, AND DEVELOPMENTAL STAGE.
RA   Rothman J.H., Maduro M.F., Strohmaier K.;
RL   Unpublished observations (JUN-2000).
CC   -!- FUNCTION: May function as transcription regulator (Probable). Essential
CC       for larval development (PubMed:14648222, Ref.3). Required for
CC       morphogenesis and function of the digestive tract (PubMed:14648222).
CC       {ECO:0000269|PubMed:14648222, ECO:0000269|Ref.3}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the gut during embryogenesis
CC       (PubMed:14648222, Ref.3). Expressed in presumptive intestinal cells and
CC       in unidentified cells in the head prior to embryonic elongation
CC       (PubMed:14648222). Highly expressed in the most anterior intestinal
CC       cell from 1.25-fold stage to 2.5-fold stage (elongating) embryos, but
CC       weakly expressed in the remaining intestine in embryos at the 1.25-fold
CC       stage (PubMed:14648222). Expressed in additional unidentified cells in
CC       the head in 2-fold stage embryos (PubMed:14648222).
CC       {ECO:0000269|PubMed:14648222, ECO:0000269|Ref.3}.
CC   -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in defects in
CC       feeding, and failed growth and development eventually leading to
CC       lethality at the larval stage of development. Morphological and
CC       functional defects around the pharyngeal intestinal valve and intestine
CC       boundary with multiple cavities surrounding the isthmus of the pharynx
CC       in 1 to 2 day old larvae, and accumulation of ingested bacteria in the
CC       anterior intestine. {ECO:0000269|PubMed:14648222}.
CC   -!- SIMILARITY: Belongs to the Odd C2H2-type zinc-finger protein family.
CC       {ECO:0000305}.
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DR   EMBL; FO080148; CCD61601.1; -; Genomic_DNA.
DR   PIR; T15298; T15298.
DR   RefSeq; NP_498552.2; NM_066151.2.
DR   AlphaFoldDB; P41995; -.
DR   SMR; P41995; -.
DR   STRING; 6239.B0280.4; -.
DR   PaxDb; P41995; -.
DR   EnsemblMetazoa; B0280.4.1; B0280.4.1; WBGene00003845.
DR   GeneID; 181893; -.
DR   KEGG; cel:CELE_B0280.4; -.
DR   UCSC; B0280.4; c. elegans.
DR   CTD; 181893; -.
DR   WormBase; B0280.4; CE34633; WBGene00003845; odd-1.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000172968; -.
DR   HOGENOM; CLU_1148069_0_0_1; -.
DR   InParanoid; P41995; -.
DR   OMA; ICKYCAR; -.
DR   OrthoDB; 1318335at2759; -.
DR   PhylomeDB; P41995; -.
DR   PRO; PR:P41995; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00003845; Expressed in embryo and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..242
FT                   /note="Protein odd-skipped-related 1"
FT                   /id="PRO_0000046889"
FT   ZN_FING         128..150
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         156..178
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         184..207
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ   SEQUENCE   242 AA;  27548 MW;  5F8FB395DA0BFEF1 CRC64;
     MTLPWNTFPG STVPPVVPSV EDIIRMLVAG QQKIAIQNLL QSQSKEQVNG TSHDLQNWLT
     SLCISPSSSP TPSNASTSTI PAQMTNENVL HLQIQSQLFS NLGTPWFLNP EQHNKTNNAI
     RKRPKKEFIC KYCARHFTKS YNLMIHERTH TNERPFHCET CGKSFRRQDH LRDHKYIHAK
     EKPHKCEICG KGFCQLRTLN VHRSCHHVQE PISETFMLGA IKFGKADSLL IDAEPLIDVT
     TI