ID   ODD2_CAEEL              Reviewed;         254 AA.
AC   Q9N5X6;
DT   06-JUL-2016, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 144.
DE   RecName: Full=Protein odd-skipped-related 2 {ECO:0000305};
GN   Name=odd-2 {ECO:0000312|WormBase:C34H3.2};
GN   ORFNames=C34H3.2 {ECO:0000312|WormBase:C34H3.2};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX   PubMed=14648222; DOI=10.1007/s00427-003-0369-x;
RA   Buckley M.S., Chau J., Hoppe P.E., Coulter D.E.;
RT   "Odd-skipped homologs function during gut development in C. elegans.";
RL   Dev. Genes Evol. 214:10-18(2004).
CC   -!- FUNCTION: May function as transcription regulator (Probable). Required
CC       for morphogenesis and function of the digestive tract.
CC       {ECO:0000269|PubMed:14648222, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the intestine from embryogenesis to
CC       adulthood. Highly expressed in the most anterior and posterior parts of
CC       the intestine in hatched larva. Also expressed in cells outside of the
CC       intestine near the anus in hatched larva.
CC       {ECO:0000269|PubMed:14648222}.
CC   -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in defects in
CC       feeding, and failed growth and development eventually leading to
CC       lethality at the late L1 to L2 stage of larval development.
CC       Morphological defects in the digestive tract, such as enlarged
CC       pharyngeal intestinal valve lumen, leading to functional defects
CC       including accumulation of ingested bacteria in the lumen of the
CC       posterior intestine and defective elimination from the anterior lumen
CC       of the intestine. {ECO:0000269|PubMed:14648222}.
CC   -!- SIMILARITY: Belongs to the Odd C2H2-type zinc-finger protein family.
CC       {ECO:0000305}.
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DR   EMBL; BX284606; CCD66692.1; -; Genomic_DNA.
DR   RefSeq; NP_509032.1; NM_076631.1.
DR   AlphaFoldDB; Q9N5X6; -.
DR   SMR; Q9N5X6; -.
DR   IntAct; Q9N5X6; 12.
DR   STRING; 6239.C34H3.2; -.
DR   EPD; Q9N5X6; -.
DR   PaxDb; Q9N5X6; -.
DR   EnsemblMetazoa; C34H3.2.1; C34H3.2.1; WBGene00003846.
DR   GeneID; 183219; -.
DR   KEGG; cel:CELE_C34H3.2; -.
DR   UCSC; C34H3.2; c. elegans.
DR   CTD; 183219; -.
DR   WormBase; C34H3.2; CE23571; WBGene00003846; odd-2.
DR   eggNOG; KOG1721; Eukaryota.
DR   HOGENOM; CLU_1095124_0_0_1; -.
DR   InParanoid; Q9N5X6; -.
DR   OMA; FTHMADS; -.
DR   OrthoDB; 1318335at2759; -.
DR   PhylomeDB; Q9N5X6; -.
DR   PRO; PR:Q9N5X6; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00003846; Expressed in larva and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..254
FT                   /note="Protein odd-skipped-related 2"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000436773"
FT   ZN_FING         124..146
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         152..174
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         180..202
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ   SEQUENCE   254 AA;  29517 MW;  B87526F6BA944520 CRC64;
     MLPWQRQVPT SIFPQSNEQV FRMMLAQQHL QLQNFLQQRK MALLAMNPEI PMITDLKKAK
     FDFTHMADSI ESEQKIKEES VSPKMSPTLT TAAVRPFVPY DQPWFMIPGR GRTTGRAARP
     KKEFICKYCD RHFTKSYNLL IHERTHTDER PYSCDVCGKA FRRQDHLRDH KYIHQKDRPF
     KCEICGKGFC QSRTLLVHRA THDPNRHSIG APVVPIKSET PLPELDPRVT LILQNLTDSF
     NSTSMTSPQI SPDR