ODD_DROME
ID ODD_DROME Reviewed; 392 AA.
AC P23803; Q9VQS9;
DT 01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 3.
DT 03-AUG-2022, entry version 171.
DE RecName: Full=Protein odd-skipped;
GN Name=odd; ORFNames=CG3851;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=2120051; DOI=10.1002/j.1460-2075.1990.tb07593.x;
RA Coulter D.E., Swaykus E.A., Beran-Koehn M.A., Goldberg D., Wieschaus E.,
RA Schedl P.;
RT "Molecular analysis of odd-skipped, a zinc finger encoding segmentation
RT gene with a novel pair-rule expression pattern.";
RL EMBO J. 9:3795-3804(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP FUNCTION.
RX PubMed=7750646; DOI=10.1006/dbio.1995.1145;
RA Mullen J.R., DiNardo S.;
RT "Establishing parasegments in Drosophila embryos: roles of the odd-skipped
RT and naked genes.";
RL Dev. Biol. 169:295-308(1995).
RN [6]
RP FUNCTION.
RX PubMed=9806933; DOI=10.1242/dev.125.23.4851;
RA Saulier-Le Drean B., Nasiadka A., Dong J., Krause H.M.;
RT "Dynamic changes in the functions of Odd-skipped during early Drosophila
RT embryogenesis.";
RL Development 125:4851-4861(1998).
RN [7]
RP TISSUE SPECIFICITY.
RX PubMed=10960790; DOI=10.1016/s0925-4773(00)00389-0;
RA Ward E.J., Coulter D.E.;
RT "odd-skipped is expressed in multiple tissues during Drosophila
RT embryogenesis.";
RL Mech. Dev. 96:233-236(2000).
RN [8]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=14597202; DOI=10.1016/j.ydbio.2003.07.011;
RA Hao I., Green R.B., Dunaevsky O., Lengyel J.A., Rauskolb C.;
RT "The odd-skipped family of zinc finger genes promotes Drosophila leg
RT segmentation.";
RL Dev. Biol. 263:282-295(2003).
CC -!- FUNCTION: Pair-rule protein that determines both the size and polarity
CC of even-numbered as well as odd-numbered parasegments during
CC embryogenesis. DNA-binding transcription factor that acts primarily as
CC a transcriptional repressor but can also function as a transcriptional
CC activator, depending on the stage of development and spatial
CC restrictions. May function redundantly with odd and drm in leg joint
CC formation during the larval stages, acting downstream of Notch
CC activation. {ECO:0000269|PubMed:14597202, ECO:0000269|PubMed:2120051,
CC ECO:0000269|PubMed:7750646, ECO:0000269|PubMed:9806933}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Has two temporally distinct modes of expression
CC during early embryogenesis; expressed in seven stripes at the
CC blastoderm stage, then during gastrulation the seven primary stripes
CC are supplemented by secondary stripes which appear in alternate
CC segments. This results in the labelling of every segment in the
CC extended germ band. Also expressed in the embryo in distinct regions of
CC the gut, the Garland cells associated with the proventriculus, the
CC pericardial cells, the lymph glands associated with the heart, in a
CC subset of cells in the central nervous system and in select apodemes.
CC Expressed in a segmentally repeated pattern in the leg disk at the
CC distal edge of each presumptive leg segment except in tarsal segments 1
CC to 4. {ECO:0000269|PubMed:10960790, ECO:0000269|PubMed:14597202,
CC ECO:0000269|PubMed:2120051}.
CC -!- SIMILARITY: Belongs to the Odd C2H2-type zinc-finger protein family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X57480; CAA40718.1; -; mRNA.
DR EMBL; AE014134; AAF51085.1; -; Genomic_DNA.
DR EMBL; BT015214; AAT94443.1; -; mRNA.
DR PIR; S11998; S11998.
DR RefSeq; NP_722922.1; NM_164546.2.
DR AlphaFoldDB; P23803; -.
DR SMR; P23803; -.
DR BioGRID; 59791; 26.
DR ELM; P23803; -.
DR IntAct; P23803; 8.
DR STRING; 7227.FBpp0077246; -.
DR PaxDb; P23803; -.
DR DNASU; 33583; -.
DR EnsemblMetazoa; FBtr0077557; FBpp0077246; FBgn0002985.
DR GeneID; 33583; -.
DR KEGG; dme:Dmel_CG3851; -.
DR CTD; 33583; -.
DR FlyBase; FBgn0002985; odd.
DR VEuPathDB; VectorBase:FBgn0002985; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_035933_1_1_1; -.
DR InParanoid; P23803; -.
DR OMA; MNQWIRN; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P23803; -.
DR SignaLink; P23803; -.
DR BioGRID-ORCS; 33583; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 33583; -.
DR PRO; PR:P23803; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0002985; Expressed in MP1 neuron (Drosophila) and 89 other tissues.
DR Genevisible; P23803; DM.
DR GO; GO:0005634; C:nucleus; ISS:FlyBase.
DR GO; GO:0003677; F:DNA binding; NAS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:FlyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007350; P:blastoderm segmentation; IMP:UniProtKB.
DR GO; GO:0048619; P:embryonic hindgut morphogenesis; IBA:GO_Central.
DR GO; GO:0009880; P:embryonic pattern specification; IBA:GO_Central.
DR GO; GO:0016348; P:imaginal disc-derived leg joint morphogenesis; IMP:FlyBase.
DR GO; GO:0007443; P:Malpighian tubule morphogenesis; IMP:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0007389; P:pattern specification process; IMP:CACAO.
DR GO; GO:0007366; P:periodic partitioning by pair rule gene; IMP:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:FlyBase.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 4.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; DNA-binding; Metal-binding; Nucleus;
KW Pair-rule protein; Reference proteome; Repeat; Repressor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..392
FT /note="Protein odd-skipped"
FT /id="PRO_0000047003"
FT ZN_FING 220..242
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 248..270
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 276..298
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 304..326
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 142..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..171
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 29
FT /note="E -> D (in Ref. 1; CAA40718)"
FT /evidence="ECO:0000305"
FT CONFLICT 185
FT /note="M -> V (in Ref. 1; CAA40718)"
FT /evidence="ECO:0000305"
FT CONFLICT 209
FT /note="G -> C (in Ref. 1; CAA40718)"
FT /evidence="ECO:0000305"
FT CONFLICT 360
FT /note="A -> V (in Ref. 1; CAA40718)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 392 AA; 44626 MW; 588B55257566688A CRC64;
MSSTSASPIS NITVDDELNL SREQDFAEED FIVIKEERET SLSPMLTPPH TPTEEPLRRV
HPAISEEAVA TQLHMRHMAH YQQQQQQQQQ QQQHRLWLQM QQQQQQHQAP QQYPVYPTAS
ADPVAVHQQL MNHWIRNAAI YQQQQQQQQH PHHHHHHGHP HHPHPHPHHV RPYPAGLHSL
HAAVMGRHFG AMPTLKLGGA GGASGVPSGA TGSSRPKKQF ICKYCNRQFT KSYNLLIHER
THTDERPYSC DICGKAFRRQ DHLRDHRYIH SKDKPFKCSD CGKGFCQSRT LAVHKVTHLE
EGPHKCPICQ RSFNQRANLK SHLQSHSEQS TKEVVVTTSP ATSHSVPNQA LSSPQPENLA
QHLPVLDLSS SSSSSEKPKR MLGFTIDEIM SR
