ODF2L_BOVIN
ID ODF2L_BOVIN Reviewed; 548 AA.
AC Q0VBY1;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 25-MAY-2022, entry version 59.
DE RecName: Full=Protein BCAP {ECO:0000250|UniProtKB:Q9ULJ1};
DE AltName: Full=Basal body centriole-associated protein;
DE AltName: Full=Outer dense fiber protein 2-like;
GN Name=ODF2L; Synonyms=BCAP;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal skin;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a suppressor of ciliogenesis, specifically, the
CC initiation of ciliogenesis. {ECO:0000250|UniProtKB:Q9ULJ1}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000250|UniProtKB:Q9ULJ1}. Cytoplasm,
CC cytoskeleton, microtubule organizing center, centrosome, centriole
CC {ECO:0000250|UniProtKB:Q9ULJ1}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome, centriolar satellite
CC {ECO:0000250|UniProtKB:Q9ULJ1}. Cytoplasm, cytoskeleton, cilium basal
CC body {ECO:0000250|UniProtKB:Q9ULJ1}. Note=Localizes to centrioles in
CC proliferative cells and basal bodies in ciliated cells. Disappears
CC during ciliogenesis but reappears, albeit at a lower levels once
CC ciliogenesis has completed. {ECO:0000250|UniProtKB:Q9ULJ1}.
CC -!- SIMILARITY: Belongs to the ODF2 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC120451; AAI20452.1; -; mRNA.
DR RefSeq; NP_001069461.1; NM_001075993.1.
DR AlphaFoldDB; Q0VBY1; -.
DR SMR; Q0VBY1; -.
DR STRING; 9913.ENSBTAP00000017157; -.
DR PaxDb; Q0VBY1; -.
DR PRIDE; Q0VBY1; -.
DR GeneID; 533508; -.
DR KEGG; bta:533508; -.
DR CTD; 57489; -.
DR eggNOG; ENOG502R83P; Eukaryota.
DR InParanoid; Q0VBY1; -.
DR OrthoDB; 328077at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0034451; C:centriolar satellite; ISS:UniProtKB.
DR GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR GO; GO:1902018; P:negative regulation of cilium assembly; ISS:UniProtKB.
DR InterPro; IPR026102; BCAP.
DR InterPro; IPR026099; Odf2-rel.
DR PANTHER; PTHR23162; PTHR23162; 3.
DR PANTHER; PTHR23162:SF7; PTHR23162:SF7; 3.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium biogenesis/degradation; Coiled coil; Cytoplasm;
KW Cytoskeleton; Reference proteome.
FT CHAIN 1..548
FT /note="Protein BCAP"
FT /id="PRO_0000308908"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 98..177
FT /evidence="ECO:0000255"
FT COILED 206..282
FT /evidence="ECO:0000255"
FT COILED 394..506
FT /evidence="ECO:0000255"
FT COMPBIAS 1..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 548 AA; 63862 MW; D230C7E0D7129AC5 CRC64;
MEETANDGSH SEELFSHFES RSEKEGLPQD ASESHLSCLK QDIQNEKTEL EALFKEAELA
TCSAELLLPL FKDTIEEISF ENRGESLSNL LEKLTDNERE NINLKNKVLE KETYIQELSS
LFQNEKANAL KASRFSQSVK VVHERLQSQI HKKEAENEKL KEHIKSLETQ ISEWNLQLKK
NKYEAVAMKE SSRQKTIALK KASKIYKQRI EHFTGDMENL TSQIREQEAK LSETVSASNA
WKSHYEKIVI EKTELEVQIE TMKKQIINLL EDLKKMEEHG KISCEEILRK LHSIEYENET
LNLENTKLKT TLATLKDEIA SVENELLELQ EVEKQQKTLI EVYKTQIQKV QEAAEMVKSR
CKNLLQENSL ITKNKNKKLK KVDENHSLLT KLSLEEENYL IQLKCENLKQ KLEQMDAENK
ELEKKLANQE ECLKHSNLKF KEKSAEYTAL ARQLEAALEE GRQKVSEEIE KMSSRERALQ
VKIVDLENEL RKKNEEQNQL VCKMNSKAQH QEVCLKEIQH SLEKSENQNE SIKNYLQFLK
TSYVTMFG