ODF2L_HUMAN
ID ODF2L_HUMAN Reviewed; 636 AA.
AC Q9ULJ1; A8MU56; B4E037; Q05C40; Q5BJG5; Q5TBX3; Q5TBX4; Q86X31;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Protein BCAP {ECO:0000305};
DE AltName: Full=Basal body centriole-associated protein {ECO:0000303|PubMed:17485331};
DE AltName: Full=Outer dense fiber protein 2-like;
GN Name=ODF2L {ECO:0000312|HGNC:HGNC:29225};
GN Synonyms=BCAP {ECO:0000303|PubMed:17485331}, KIAA1229;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=10574462; DOI=10.1093/dnares/6.5.337;
RA Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XV. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 6:337-345(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-402 (ISOFORM 5).
RC TISSUE=Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Placenta;
RA Li W.B., Gruber C., Jessee J., Polayes D.;
RT "Full-length cDNA libraries and normalization.";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND VARIANT
RP ARG-350.
RC TISSUE=Brain, Pituitary, and Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=17485331; DOI=10.2741/2344;
RA Ponsard C., Seltzer V., Perret E., Tournier F., Middendorp S.;
RT "Identification of BCAP, a new protein associated with basal bodies and
RT centrioles.";
RL Front. Biosci. 12:3683-3693(2007).
RN [8]
RP SUBCELLULAR LOCATION (ISOFORM 1 AND 6), AND FUNCTION.
RX PubMed=28775150; DOI=10.1242/jcs.196642;
RA de Saram P., Iqbal A., Murdoch J.N., Wilkinson C.J.;
RT "BCAP is a centriolar satellite protein and inhibitor of ciliogenesis.";
RL J. Cell Sci. 130:3360-3373(2017).
CC -!- FUNCTION: Acts as a suppressor of ciliogenesis, specifically, the
CC initiation of ciliogenesis. {ECO:0000269|PubMed:28775150}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000269|PubMed:17485331}. Cytoplasm,
CC cytoskeleton, microtubule organizing center, centrosome, centriole
CC {ECO:0000269|PubMed:17485331}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome, centriolar satellite
CC {ECO:0000269|PubMed:28775150}. Cytoplasm, cytoskeleton, cilium basal
CC body {ECO:0000269|PubMed:17485331}. Note=Localizes to centrioles in
CC proliferative cells and basal bodies in ciliated cells
CC (PubMed:17485331). Disappears during ciliogenesis but reappears, albeit
CC at a lower levels once ciliogenesis has completed (PubMed:28775150).
CC {ECO:0000269|PubMed:17485331, ECO:0000269|PubMed:28775150}.
CC -!- SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome, centriolar satellite
CC {ECO:0000269|PubMed:28775150}. Note=Not present in the centrioles in
CC cycling cells. Disappears during ciliogenesis.
CC {ECO:0000269|PubMed:28775150}.
CC -!- SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome, centriolar satellite
CC {ECO:0000269|PubMed:28775150}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome, centriole {ECO:0000269|PubMed:28775150}.
CC Note=Disappears during ciliogenesis but reappears, albeit at a lower
CC levels once ciliogenesis has completed. {ECO:0000269|PubMed:28775150}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1; Synonyms=L-BCAP {ECO:0000303|PubMed:17485331};
CC IsoId=Q9ULJ1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9ULJ1-2; Sequence=VSP_029058, VSP_029060;
CC Name=3;
CC IsoId=Q9ULJ1-3; Sequence=VSP_029057, VSP_029059;
CC Name=4;
CC IsoId=Q9ULJ1-4; Sequence=VSP_029057, VSP_029060;
CC Name=5;
CC IsoId=Q9ULJ1-5; Sequence=VSP_040930, VSP_029057, VSP_029060;
CC Name=6;
CC IsoId=Q9ULJ1-6; Sequence=VSP_029057, VSP_029058, VSP_029060;
CC -!- TISSUE SPECIFICITY: Mainly expressed in trachea and testis. Not
CC detected in bone marrow, bladder, leukocytes. Only weakly detected in
CC tongue, stomach, brain and ovaries. {ECO:0000269|PubMed:17485331}.
CC -!- SIMILARITY: Belongs to the ODF2 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH29420.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC Sequence=AAH47368.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC Sequence=AK308351; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAA86543.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB033055; BAA86543.1; ALT_INIT; mRNA.
DR EMBL; AK303209; BAG64299.1; -; mRNA.
DR EMBL; AK308351; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; CR591511; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC119749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL136382; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471097; EAW73190.1; -; Genomic_DNA.
DR EMBL; CH471097; EAW73192.1; -; Genomic_DNA.
DR EMBL; BC029420; AAH29420.1; ALT_SEQ; mRNA.
DR EMBL; BC047368; AAH47368.1; ALT_SEQ; mRNA.
DR EMBL; BC091490; AAH91490.1; -; mRNA.
DR CCDS; CCDS30763.2; -. [Q9ULJ1-3]
DR CCDS; CCDS41354.2; -. [Q9ULJ1-1]
DR CCDS; CCDS53339.1; -. [Q9ULJ1-6]
DR RefSeq; NP_001007023.2; NM_001007022.2. [Q9ULJ1-1]
DR RefSeq; NP_001171694.1; NM_001184765.1. [Q9ULJ1-2]
DR RefSeq; NP_001171695.1; NM_001184766.1. [Q9ULJ1-6]
DR RefSeq; NP_065780.2; NM_020729.2. [Q9ULJ1-3]
DR RefSeq; XP_005271111.1; XM_005271054.3.
DR RefSeq; XP_011540121.1; XM_011541819.2.
DR RefSeq; XP_016857366.1; XM_017001877.1.
DR AlphaFoldDB; Q9ULJ1; -.
DR SMR; Q9ULJ1; -.
DR BioGRID; 121557; 37.
DR IntAct; Q9ULJ1; 40.
DR MINT; Q9ULJ1; -.
DR STRING; 9606.ENSP00000359600; -.
DR iPTMnet; Q9ULJ1; -.
DR PhosphoSitePlus; Q9ULJ1; -.
DR BioMuta; ODF2L; -.
DR DMDM; 160013283; -.
DR EPD; Q9ULJ1; -.
DR jPOST; Q9ULJ1; -.
DR MassIVE; Q9ULJ1; -.
DR MaxQB; Q9ULJ1; -.
DR PaxDb; Q9ULJ1; -.
DR PeptideAtlas; Q9ULJ1; -.
DR PRIDE; Q9ULJ1; -.
DR ProteomicsDB; 85040; -. [Q9ULJ1-1]
DR ProteomicsDB; 85041; -. [Q9ULJ1-2]
DR ProteomicsDB; 85042; -. [Q9ULJ1-3]
DR ProteomicsDB; 85043; -. [Q9ULJ1-4]
DR ProteomicsDB; 85044; -. [Q9ULJ1-5]
DR ProteomicsDB; 85045; -. [Q9ULJ1-6]
DR Antibodypedia; 33581; 114 antibodies from 23 providers.
DR DNASU; 57489; -.
DR Ensembl; ENST00000294678.6; ENSP00000294678.2; ENSG00000122417.15. [Q9ULJ1-3]
DR Ensembl; ENST00000317336.11; ENSP00000320165.8; ENSG00000122417.15. [Q9ULJ1-1]
DR Ensembl; ENST00000359242.7; ENSP00000359600.2; ENSG00000122417.15. [Q9ULJ1-1]
DR Ensembl; ENST00000370566.7; ENSP00000359597.2; ENSG00000122417.15. [Q9ULJ1-6]
DR GeneID; 57489; -.
DR KEGG; hsa:57489; -.
DR UCSC; uc001dll.3; human. [Q9ULJ1-1]
DR CTD; 57489; -.
DR DisGeNET; 57489; -.
DR GeneCards; ODF2L; -.
DR HGNC; HGNC:29225; ODF2L.
DR HPA; ENSG00000122417; Low tissue specificity.
DR neXtProt; NX_Q9ULJ1; -.
DR OpenTargets; ENSG00000122417; -.
DR PharmGKB; PA142671232; -.
DR VEuPathDB; HostDB:ENSG00000122417; -.
DR eggNOG; ENOG502R83P; Eukaryota.
DR GeneTree; ENSGT00530000063497; -.
DR InParanoid; Q9ULJ1; -.
DR OMA; WKSRYEK; -.
DR OrthoDB; 328077at2759; -.
DR PhylomeDB; Q9ULJ1; -.
DR TreeFam; TF328605; -.
DR PathwayCommons; Q9ULJ1; -.
DR SignaLink; Q9ULJ1; -.
DR BioGRID-ORCS; 57489; 14 hits in 1077 CRISPR screens.
DR ChiTaRS; ODF2L; human.
DR GenomeRNAi; 57489; -.
DR Pharos; Q9ULJ1; Tdark.
DR PRO; PR:Q9ULJ1; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9ULJ1; protein.
DR Bgee; ENSG00000122417; Expressed in right uterine tube and 168 other tissues.
DR ExpressionAtlas; Q9ULJ1; baseline and differential.
DR Genevisible; Q9ULJ1; HS.
DR GO; GO:0034451; C:centriolar satellite; IDA:UniProtKB.
DR GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR GO; GO:0005813; C:centrosome; IDA:UniProtKB.
DR GO; GO:0036064; C:ciliary basal body; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR GO; GO:1902018; P:negative regulation of cilium assembly; IDA:UniProtKB.
DR GO; GO:1902017; P:regulation of cilium assembly; IBA:GO_Central.
DR InterPro; IPR026102; BCAP.
DR InterPro; IPR026099; Odf2-rel.
DR PANTHER; PTHR23162; PTHR23162; 1.
DR PANTHER; PTHR23162:SF7; PTHR23162:SF7; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell projection; Cilium biogenesis/degradation;
KW Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..636
FT /note="Protein BCAP"
FT /id="PRO_0000308909"
FT COILED 36..97
FT /evidence="ECO:0000255"
FT COILED 141..220
FT /evidence="ECO:0000255"
FT COILED 249..325
FT /evidence="ECO:0000255"
FT COILED 377..484
FT /evidence="ECO:0000255"
FT COILED 519..631
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..131
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_040930"
FT VAR_SEQ 353..381
FT /note="Missing (in isoform 3, isoform 4, isoform 5 and
FT isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|Ref.3"
FT /id="VSP_029057"
FT VAR_SEQ 454..506
FT /note="Missing (in isoform 2 and isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_029058"
FT VAR_SEQ 506
FT /note="Q -> QILKQWEEYSVLAW (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029059"
FT VAR_SEQ 632..636
FT /note="DPETP -> KAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKTSYVTMFE
FT (in isoform 2, isoform 4, isoform 5 and isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|Ref.3"
FT /id="VSP_029060"
FT VARIANT 177
FT /note="R -> H (in dbSNP:rs12032435)"
FT /id="VAR_036882"
FT VARIANT 350
FT /note="K -> R (in dbSNP:rs17854440)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_036883"
FT CONFLICT 135
FT /note="E -> G (in Ref. 6; AAH47368)"
FT /evidence="ECO:0000305"
FT CONFLICT 203
FT /note="L -> S (in Ref. 6; AAH29420)"
FT /evidence="ECO:0000305"
FT CONFLICT 339
FT /note="Y -> H (in Ref. 1; BAA86543)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 636 AA; 73728 MW; D74FAB4F22F21581 CRC64;
MEKAVNDGSH SEELFCHLKT ISEKEDLPRC TSESHLSCLK QDILNEKTEL EATLKEAELV
THSVELLLPL FKDTIEKINF ENANLSALNL KISEQKEILI KELDTFKSVK LALEHLLRKR
DYKQTGDNLS SMLLENLTDN ESENTNLKKK VFEKEAHIQE LSCLFQSEKA NTLKANRFSQ
SVKVVHERLQ IQIHKREAEN DKLKEYVKSL ETKIAKWNLQ SRMNKNEAIV MKEASRQKTV
ALKKASKVYK QRLDHFTGAI EKLTSQIRDQ EAKLSETISA SNAWKSHYEK IVIEKTELEV
QIETMKKQII NLLEDLKKME DHGKNSCEEI LRKVHSIEYE NETLNLENTK LKLRFPCRIT
ESKNMNILIV LDMLCYISSE KTTLAALKDE VVSVENELSE LQEVEKKQKT LIEMYKTQVQ
KLQEAAEIVK SRCENLLHKN NQITKTKNKN VEKMRGQMES HLKELERVCD SLTAAERRLH
ECQESLQCCK GKCADQEHTI RELQGQVDGN HNLLTKLSLE EENCLIQLKC ENLQQKLEQM
DAENKELEKK LANQEECLKH SNLKFKEKSA EYTALARQLE AALEEGRQKV AEEIEKMSSR
ESALQIKILD LETELRKKNE EQNQLVCKMN SDPETP
