ODF3A_HUMAN
ID ODF3A_HUMAN Reviewed; 254 AA.
AC Q96PU9; B7ZLT0; Q69YX0;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Outer dense fiber protein 3;
DE AltName: Full=Outer dense fiber of sperm tails protein 3;
DE AltName: Full=Sperm tail protein SHIPPO 1;
DE AltName: Full=Transcript induced in spermiogenesis protein 50;
GN Name=ODF3; Synonyms=SHIPPO1, TISP50;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC TISSUE=Testis;
RX PubMed=11870087; DOI=10.1095/biolreprod66.3.785;
RA Egydio de Carvalho C., Tanaka H., Iguchi N., Ventela S., Nojima H.,
RA Nishimune Y.;
RT "Molecular cloning and characterization of a complementary DNA encoding
RT sperm tail protein SHIPPO 1.";
RL Biol. Reprod. 66:785-795(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RA Sasaki Y., Miyamoto T., Sengoku K., Hayashi H., Takuma N., Ishikawa M.;
RT "The human transcript induced in spermatogenesis 50.";
RL Reprod. Med. Biol. 3:237-243(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Outer dense fibers are filamentous structures located on the
CC outside of the axoneme in the midpiece and principal piece of the
CC mammalian sperm tail. May help to maintain the passive elastic
CC structures and elastic recoil of the sperm tail.
CC -!- INTERACTION:
CC Q96PU9; P63167: DYNLL1; NbExp=3; IntAct=EBI-12002088, EBI-349105;
CC Q96PU9; Q86XE5: HOGA1; NbExp=3; IntAct=EBI-12002088, EBI-9658477;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Expressed in the
CC cytoplasmic lobe of spermatids. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q96PU9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96PU9-2; Sequence=VSP_027686, VSP_027687;
CC Name=3;
CC IsoId=Q96PU9-3; Sequence=VSP_054893;
CC -!- TISSUE SPECIFICITY: Testis-specific. {ECO:0000269|PubMed:11870087,
CC ECO:0000269|Ref.2}.
CC -!- MISCELLANEOUS: 'Shippo' is a Japanese word for tail.
CC -!- SIMILARITY: Belongs to the ODF3 family. {ECO:0000305}.
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DR EMBL; AB067774; BAB70734.1; -; mRNA.
DR EMBL; AY713299; AAW83203.1; -; mRNA.
DR EMBL; AL133658; CAH10709.1; -; mRNA.
DR EMBL; AC069287; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC126222; AAI26223.1; -; mRNA.
DR EMBL; BC126248; AAI26249.1; -; mRNA.
DR EMBL; BC144022; AAI44023.1; -; mRNA.
DR CCDS; CCDS65981.1; -. [Q96PU9-3]
DR CCDS; CCDS7688.1; -. [Q96PU9-1]
DR RefSeq; NP_001273065.1; NM_001286136.1. [Q96PU9-3]
DR RefSeq; NP_444510.2; NM_053280.4. [Q96PU9-1]
DR AlphaFoldDB; Q96PU9; -.
DR BioGRID; 125258; 11.
DR IntAct; Q96PU9; 2.
DR STRING; 9606.ENSP00000325868; -.
DR iPTMnet; Q96PU9; -.
DR PhosphoSitePlus; Q96PU9; -.
DR BioMuta; ODF3; -.
DR DMDM; 74717117; -.
DR jPOST; Q96PU9; -.
DR MassIVE; Q96PU9; -.
DR PaxDb; Q96PU9; -.
DR PeptideAtlas; Q96PU9; -.
DR PRIDE; Q96PU9; -.
DR ProteomicsDB; 7234; -.
DR ProteomicsDB; 77767; -. [Q96PU9-1]
DR ProteomicsDB; 77768; -. [Q96PU9-2]
DR Antibodypedia; 48707; 106 antibodies from 19 providers.
DR DNASU; 113746; -.
DR Ensembl; ENST00000325113.9; ENSP00000325868.5; ENSG00000177947.15. [Q96PU9-1]
DR Ensembl; ENST00000525282.1; ENSP00000436588.1; ENSG00000177947.15. [Q96PU9-3]
DR GeneID; 113746; -.
DR KEGG; hsa:113746; -.
DR MANE-Select; ENST00000325113.9; ENSP00000325868.5; NM_053280.5; NP_444510.2.
DR UCSC; uc001lob.4; human. [Q96PU9-1]
DR CTD; 113746; -.
DR DisGeNET; 113746; -.
DR GeneCards; ODF3; -.
DR HGNC; HGNC:19905; ODF3.
DR HPA; ENSG00000177947; Tissue enriched (testis).
DR MIM; 608356; gene.
DR neXtProt; NX_Q96PU9; -.
DR OpenTargets; ENSG00000177947; -.
DR PharmGKB; PA134952791; -.
DR VEuPathDB; HostDB:ENSG00000177947; -.
DR eggNOG; ENOG502QUIJ; Eukaryota.
DR GeneTree; ENSGT00940000156191; -.
DR HOGENOM; CLU_088282_0_0_1; -.
DR InParanoid; Q96PU9; -.
DR OMA; AYRQTDM; -.
DR OrthoDB; 920847at2759; -.
DR PhylomeDB; Q96PU9; -.
DR TreeFam; TF325804; -.
DR PathwayCommons; Q96PU9; -.
DR SignaLink; Q96PU9; -.
DR BioGRID-ORCS; 113746; 17 hits in 688 CRISPR screens.
DR GenomeRNAi; 113746; -.
DR Pharos; Q96PU9; Tbio.
DR PRO; PR:Q96PU9; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q96PU9; protein.
DR Bgee; ENSG00000177947; Expressed in left testis and 26 other tissues.
DR ExpressionAtlas; Q96PU9; baseline and differential.
DR Genevisible; Q96PU9; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0001520; C:outer dense fiber; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR010736; SHIPPO-rpt.
DR Pfam; PF07004; SHIPPO-rpt; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Developmental protein; Differentiation;
KW Reference proteome; Repeat; Spermatogenesis.
FT CHAIN 1..254
FT /note="Outer dense fiber protein 3"
FT /id="PRO_0000299464"
FT REPEAT 180..205
FT /note="STPGR 1"
FT REPEAT 216..241
FT /note="STPGR 2"
FT REGION 207..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 104..138
FT /note="GDYFPEKSTKYVFDSAPSHSISARTKAFRVDSTPG -> ALKSAFPSWTPRD
FT PTWSPPVLEPRGPTPRMLGSPP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_027686"
FT VAR_SEQ 139..254
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_027687"
FT VAR_SEQ 178..224
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_054893"
SQ SEQUENCE 254 AA; 27710 MW; 549AA2DEA35201E5 CRC64;
MTEEVWMGTW RPHRPRGPIM ALYSSPGPKY LIPPTTGFMK HTPTKLRAPA YSFRGAPMLL
AENCSPGPRY NVNPKILRTG KDLGPAYSIL GRYQTKTMLT PGPGDYFPEK STKYVFDSAP
SHSISARTKA FRVDSTPGPA AYMLPMVMGP NTVGKASQPS FSIKGRSKLG GFSDDLHKTP
GPAAYRQTDV RVTKFKAPQY TMAARVEPPG DKTLKPGPGA HSPEKVTLTK PCAPVVTFGI
KHSDYMTPLL VDVE
