ODF3A_MOUSE
ID ODF3A_MOUSE Reviewed; 254 AA.
AC Q920N1; Q9DAF2;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 2.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Outer dense fiber protein 3;
DE AltName: Full=Outer dense fiber of sperm tails protein 3;
DE AltName: Full=Sperm tail protein SHIPPO 1;
GN Name=Odf3; Synonyms=Shippo1; ORFNames=Beta390;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC TISSUE=Testis;
RX PubMed=11870087; DOI=10.1095/biolreprod66.3.785;
RA Egydio de Carvalho C., Tanaka H., Iguchi N., Ventela S., Nojima H.,
RA Nishimune Y.;
RT "Molecular cloning and characterization of a complementary DNA encoding
RT sperm tail protein SHIPPO 1.";
RL Biol. Reprod. 66:785-795(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Outer dense fibers are filamentous structures located on the
CC outside of the axoneme in the midpiece and principal piece of the
CC mammalian sperm tail. May help to maintain the passive elastic
CC structures and elastic recoil of the sperm tail.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11870087}.
CC Note=Expressed in the cytoplasmic lobe of spermatids.
CC -!- TISSUE SPECIFICITY: Testis-specific (at protein level). Expression
CC restricted to the germ cell fraction, absent in somatic cell fractions
CC such as Sertoli and Leydig cells. Expression detected in the third week
CC postpartum (23 days) after haploid germ cells developed, expression
CC increased with age. Expressed in the tails of elongated spermatids
CC sticking out toward the tubular lumen, and in cytoplasmic droplets
CC still attached to the spermatid tail membrane. Expressed in the tails
CC of mature sperm, from the connecting piece proximal to the head, along
CC the middle and principal pieces, down to the distal end piece.
CC {ECO:0000269|PubMed:11870087, ECO:0000269|PubMed:16141072}.
CC -!- MISCELLANEOUS: 'Shippo' is a Japanese word for tail.
CC -!- SIMILARITY: Belongs to the ODF3 family. {ECO:0000305}.
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DR EMBL; AB067773; BAB70733.1; -; mRNA.
DR EMBL; AK005883; BAB24298.1; -; mRNA.
DR EMBL; BC104105; AAI04106.1; -; mRNA.
DR EMBL; BC104106; AAI04107.1; -; mRNA.
DR EMBL; BC106806; AAI06807.1; -; mRNA.
DR CCDS; CCDS40177.1; -.
DR RefSeq; NP_081295.2; NM_027019.3.
DR AlphaFoldDB; Q920N1; -.
DR STRING; 10090.ENSMUSP00000026555; -.
DR iPTMnet; Q920N1; -.
DR PhosphoSitePlus; Q920N1; -.
DR PaxDb; Q920N1; -.
DR PRIDE; Q920N1; -.
DR ProteomicsDB; 293925; -.
DR Antibodypedia; 48707; 106 antibodies from 19 providers.
DR DNASU; 69287; -.
DR Ensembl; ENSMUST00000026555; ENSMUSP00000026555; ENSMUSG00000025482.
DR GeneID; 69287; -.
DR KEGG; mmu:69287; -.
DR UCSC; uc009kih.1; mouse.
DR CTD; 113746; -.
DR MGI; MGI:1916537; Odf3.
DR VEuPathDB; HostDB:ENSMUSG00000025482; -.
DR eggNOG; ENOG502QUIJ; Eukaryota.
DR GeneTree; ENSGT00940000156191; -.
DR HOGENOM; CLU_088282_0_0_1; -.
DR InParanoid; Q920N1; -.
DR OMA; AYRQTDM; -.
DR OrthoDB; 920847at2759; -.
DR PhylomeDB; Q920N1; -.
DR TreeFam; TF325804; -.
DR BioGRID-ORCS; 69287; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q920N1; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q920N1; protein.
DR Bgee; ENSMUSG00000025482; Expressed in seminiferous tubule of testis and 7 other tissues.
DR ExpressionAtlas; Q920N1; baseline and differential.
DR Genevisible; Q920N1; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0001520; C:outer dense fiber; IDA:MGI.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR010736; SHIPPO-rpt.
DR Pfam; PF07004; SHIPPO-rpt; 4.
PE 1: Evidence at protein level;
KW Cytoplasm; Developmental protein; Differentiation; Reference proteome;
KW Repeat; Spermatogenesis.
FT CHAIN 1..254
FT /note="Outer dense fiber protein 3"
FT /id="PRO_0000299465"
FT REPEAT 180..205
FT /note="STPGR 1"
FT REPEAT 216..241
FT /note="STPGR 2"
FT REGION 207..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 239
FT /note="G -> C (in Ref. 1; BAB70733)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 254 AA; 27650 MW; D9621C6A1411368C CRC64;
MAEEVWMGTW RPHRPRGPIM ALYSSPGPKY LIPPTTGFVK HTPTKLRAPA YSFRGAPMLL
AENCSPGPRY SVNPKILKTG KDLGPAYSIL GRYHTKTLLT PGPGDYFPEK STKYVFDSAP
SHSISARTKT FRVDSTPGPA AYMLPVVMGP HTVGKVSQPS FSIKGRSKLG SFSDDLHKTP
GPAAYRQTEV QVTKFKAPQY TMAARVEPPG DKTLKPGPGA HSPEKVTLNK PCAPTVTFGI
KHSDYMTPLV VDVE
