ODF3B_HUMAN
ID ODF3B_HUMAN Reviewed; 253 AA.
AC A8MYP8; A0PK18;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Outer dense fiber protein 3B;
DE AltName: Full=Outer dense fiber protein 3-like protein 3;
GN Name=ODF3B; Synonyms=ODF3L3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC A8MYP8; P35609: ACTN2; NbExp=3; IntAct=EBI-12010090, EBI-77797;
CC A8MYP8; Q08043: ACTN3; NbExp=3; IntAct=EBI-12010090, EBI-2880652;
CC A8MYP8; Q13643: FHL3; NbExp=3; IntAct=EBI-12010090, EBI-741101;
CC A8MYP8; O75031: HSF2BP; NbExp=3; IntAct=EBI-12010090, EBI-7116203;
CC A8MYP8; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-12010090, EBI-3957694;
CC A8MYP8; Q99750: MDFI; NbExp=3; IntAct=EBI-12010090, EBI-724076;
CC A8MYP8; Q13064: MKRN3; NbExp=3; IntAct=EBI-12010090, EBI-2340269;
CC A8MYP8; P02549: SPTA1; NbExp=3; IntAct=EBI-12010090, EBI-375617;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A8MYP8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A8MYP8-2; Sequence=VSP_034995, VSP_034996, VSP_034997;
CC -!- SIMILARITY: Belongs to the ODF3 family. {ECO:0000305}.
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DR EMBL; U62317; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC127934; AAI27935.1; -; mRNA.
DR CCDS; CCDS43039.1; -. [A8MYP8-1]
DR RefSeq; NP_001014440.2; NM_001014440.3. [A8MYP8-1]
DR AlphaFoldDB; A8MYP8; -.
DR BioGRID; 136932; 8.
DR IntAct; A8MYP8; 8.
DR STRING; 9606.ENSP00000382804; -.
DR iPTMnet; A8MYP8; -.
DR PhosphoSitePlus; A8MYP8; -.
DR BioMuta; ODF3B; -.
DR EPD; A8MYP8; -.
DR MassIVE; A8MYP8; -.
DR PaxDb; A8MYP8; -.
DR PeptideAtlas; A8MYP8; -.
DR PRIDE; A8MYP8; -.
DR ProteomicsDB; 2415; -. [A8MYP8-1]
DR ProteomicsDB; 2416; -. [A8MYP8-2]
DR Antibodypedia; 53940; 74 antibodies from 11 providers.
DR DNASU; 440836; -.
DR Ensembl; ENST00000329363.9; ENSP00000382804.2; ENSG00000177989.14. [A8MYP8-1]
DR Ensembl; ENST00000682240.1; ENSP00000507825.1; ENSG00000177989.14. [A8MYP8-1]
DR GeneID; 440836; -.
DR KEGG; hsa:440836; -.
DR MANE-Select; ENST00000329363.9; ENSP00000382804.2; NM_001014440.4; NP_001014440.2.
DR UCSC; uc003bmh.2; human. [A8MYP8-1]
DR CTD; 440836; -.
DR DisGeNET; 440836; -.
DR GeneCards; ODF3B; -.
DR HGNC; HGNC:34388; ODF3B.
DR HPA; ENSG00000177989; Tissue enhanced (fallopian).
DR neXtProt; NX_A8MYP8; -.
DR OpenTargets; ENSG00000177989; -.
DR PharmGKB; PA162398386; -.
DR VEuPathDB; HostDB:ENSG00000177989; -.
DR eggNOG; ENOG502QUIJ; Eukaryota.
DR GeneTree; ENSGT00940000161995; -.
DR HOGENOM; CLU_088282_1_0_1; -.
DR InParanoid; A8MYP8; -.
DR OMA; LMGRTQK; -.
DR PhylomeDB; A8MYP8; -.
DR TreeFam; TF325804; -.
DR PathwayCommons; A8MYP8; -.
DR SignaLink; A8MYP8; -.
DR BioGRID-ORCS; 440836; 13 hits in 1067 CRISPR screens.
DR ChiTaRS; ODF3B; human.
DR GenomeRNAi; 440836; -.
DR Pharos; A8MYP8; Tdark.
DR PRO; PR:A8MYP8; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; A8MYP8; protein.
DR Bgee; ENSG00000177989; Expressed in right uterine tube and 136 other tissues.
DR ExpressionAtlas; A8MYP8; baseline and differential.
DR Genevisible; A8MYP8; HS.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR InterPro; IPR010736; SHIPPO-rpt.
DR Pfam; PF07004; SHIPPO-rpt; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..253
FT /note="Outer dense fiber protein 3B"
FT /id="PRO_0000346440"
FT REPEAT 182..207
FT /note="STPGR"
FT VAR_SEQ 1..36
FT /note="MGSDAWVGLWRPHRPRGPIAAHYGGPGPKYKLPPNT -> MGLGAGPGQTLT
FT RMLP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034995"
FT VAR_SEQ 106..129
FT /note="RYFPERAGNATYPSAPRHTIAPRN -> QDPRAPGHPNAELPPGRPTWEPPT
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034996"
FT VAR_SEQ 130..253
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034997"
SQ SEQUENCE 253 AA; 27280 MW; AB7BCC87C5347B5A CRC64;
MGSDAWVGLW RPHRPRGPIA AHYGGPGPKY KLPPNTGYAL HDPSRPRAPA FTFGARFPTQ
QTTCGPGPGH LVPARMTVRG TDGAPAYSIY GRPRRSAPFL TPGPGRYFPE RAGNATYPSA
PRHTIAPRNW GVQAEQQSPG PAAYTVPSLL GPRVIGKVSA PTCSIYGRRA AGSFFEDLSK
TPGPCAYQVV SPGVYKSRAP QFTILARTSL PQDNTRKPGP AAYNVDQHRK PRGWSFGIRH
SDYLAPLVTD ADN
