ODFP1_BOVIN
ID ODFP1_BOVIN Reviewed; 262 AA.
AC Q29438;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Outer dense fiber protein 1;
GN Name=ODF1; Synonyms=ODFP;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Testis;
RX PubMed=7576240; DOI=10.1515/bchm3.1995.376.7.431;
RA Kim Y., Adham I.M., Haack T., Kremling H., Engel W.;
RT "Molecular cloning and characterization of the bovine and porcine outer
RT dense fibers cDNA and organization of the bovine gene.";
RL Biol. Chem. Hoppe-Seyler 376:431-435(1995).
CC -!- FUNCTION: Component of the outer dense fibers (ODF) of spermatozoa. ODF
CC are filamentous structures located on the outside of the axoneme in the
CC midpiece and principal piece of the mammalian sperm tail and may help
CC to maintain the passive elastic structures and elastic recoil of the
CC sperm tail.
CC -!- SUBUNIT: Interacts (via leucine zipper motif) with TCP11 (By
CC similarity). Interacts with SPAG4 (By similarity). Interacts with KLC3
CC (By similarity). {ECO:0000250|UniProtKB:P21769,
CC ECO:0000250|UniProtKB:Q14990}.
CC -!- TISSUE SPECIFICITY: Testis.
CC -!- DOMAIN: The C-terminal contains many C-X-P repeats.
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DR EMBL; X69515; CAA49266.1; -; Genomic_DNA.
DR EMBL; X69514; CAA49265.1; -; mRNA.
DR PIR; S56101; S56101.
DR AlphaFoldDB; Q29438; -.
DR SMR; Q29438; -.
DR IntAct; Q29438; 1.
DR MINT; Q29438; -.
DR STRING; 9913.ENSBTAP00000004476; -.
DR PaxDb; Q29438; -.
DR PRIDE; Q29438; -.
DR eggNOG; ENOG502S68A; Eukaryota.
DR InParanoid; Q29438; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0001520; C:outer dense fiber; ISS:AgBase.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR CDD; cd06482; ACD_HspB10; 1.
DR Gene3D; 2.60.40.790; -; 1.
DR InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR037552; ODF1_ACD.
DR InterPro; IPR037389; ODFP.
DR PANTHER; PTHR17125; PTHR17125; 1.
DR Pfam; PF00011; HSP20; 1.
DR SUPFAM; SSF49764; SSF49764; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Phosphoprotein; Reference proteome;
KW Repeat; Spermatogenesis.
FT CHAIN 1..262
FT /note="Outer dense fiber protein 1"
FT /id="PRO_0000058023"
FT REPEAT 34..38
FT /note="1"
FT REPEAT 73..77
FT /note="2"
FT REGION 34..77
FT /note="2 X 5 AA repeats of [RC]-C-L-C-D"
FT REGION 209..250
FT /note="C-X-P repeat region"
FT MOD_RES 5
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P21769"
FT MOD_RES 10
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P21769"
FT MOD_RES 64
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P21769"
FT MOD_RES 86
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P21769"
FT MOD_RES 122
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P21769"
FT MOD_RES 123
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P21769"
FT MOD_RES 151
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P21769"
FT MOD_RES 167
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P21769"
FT MOD_RES 189
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P21769"
FT MOD_RES 194
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P21769"
SQ SEQUENCE 262 AA; 29435 MW; 818B6D50AA4F8523 CRC64;
MAALSCLLDS VRRDIKKVDR ELRQLRCIDE LSARCLCDLY MHPYCCCDLH PYPYCLCYSK
RSRSCGLCDL YPCCLCDVKL YCLRPSLRSL ERKAIRAIED EKRELAKLRR TTNRILASSC
CSSNILGSVN VCGFEPDQVK VRVKDGKVCV SAERENRYDC LGSKKYSYMN ICKEFSLPPC
VDEKDVTYSY GLGSCVKIES PCYPCTSPCN PCNPCNPCSP CSPCNPCNPC SPCSPCSPCN
PCDPCNPCYP CGSRFSCRKM IL