ODFP4_HUMAN
ID ODFP4_HUMAN Reviewed; 257 AA.
AC Q2M2E3; Q8J021;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 2.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Outer dense fiber protein 4;
DE AltName: Full=Outer dense fiber of sperm tails protein 4;
DE AltName: Full=Testis-specific protein oppo 1;
DE Short=hOPPO1;
GN Name=ODF4; Synonyms=OPPO1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANTS MET-98 AND
RP CYS-139.
RX PubMed=12728016; DOI=10.1093/molehr/gag030;
RA Kitamura K., Miyagawa Y., Iguchi N., Nishimura H., Tanaka H., Nishimune Y.;
RT "Molecular cloning and characterization of the human orthologue of the oppo
RT 1 gene encoding a sperm tail protein.";
RL Mol. Hum. Reprod. 9:237-243(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS MET-98 AND CYS-139.
RA Miyamoto T.;
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ARG-34; MET-98 AND
RP CYS-139.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the outer dense fibers (ODF) of spermatozoa
CC which could be involved in sperm tail structure, sperm movement and
CC general organization of cellular cytoskeleton. {ECO:0000250}.
CC -!- INTERACTION:
CC Q2M2E3; Q06432: CACNG1; NbExp=3; IntAct=EBI-12382569, EBI-9686780;
CC Q2M2E3; P21926: CD9; NbExp=3; IntAct=EBI-12382569, EBI-4280101;
CC Q2M2E3; O14735: CDIPT; NbExp=3; IntAct=EBI-12382569, EBI-358858;
CC Q2M2E3; Q8TBE1: CNIH3; NbExp=3; IntAct=EBI-12382569, EBI-12208021;
CC Q2M2E3; P81534: DEFB103B; NbExp=3; IntAct=EBI-12382569, EBI-12074168;
CC Q2M2E3; Q15125: EBP; NbExp=3; IntAct=EBI-12382569, EBI-3915253;
CC Q2M2E3; Q86VI4: LAPTM4B; NbExp=3; IntAct=EBI-12382569, EBI-3267258;
CC Q2M2E3; Q9NX47: MARCHF5; NbExp=3; IntAct=EBI-12382569, EBI-2341610;
CC Q2M2E3; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12382569, EBI-16439278;
CC Q2M2E3; Q5J8X5: MS4A13; NbExp=3; IntAct=EBI-12382569, EBI-12070086;
CC Q2M2E3; Q9NZG7: NINJ2; NbExp=3; IntAct=EBI-12382569, EBI-10317425;
CC Q2M2E3; Q96GQ5: RUSF1; NbExp=3; IntAct=EBI-12382569, EBI-8636004;
CC Q2M2E3; Q9NTJ5: SACM1L; NbExp=3; IntAct=EBI-12382569, EBI-3917235;
CC Q2M2E3; Q96AG3: SLC25A46; NbExp=3; IntAct=EBI-12382569, EBI-10281975;
CC Q2M2E3; Q9NVC3: SLC38A7; NbExp=3; IntAct=EBI-12382569, EBI-10314552;
CC Q2M2E3; P55061: TMBIM6; NbExp=6; IntAct=EBI-12382569, EBI-1045825;
CC Q2M2E3; Q8WW34-2: TMEM239; NbExp=3; IntAct=EBI-12382569, EBI-11528917;
CC Q2M2E3; Q96B49: TOMM6; NbExp=3; IntAct=EBI-12382569, EBI-10826510;
CC Q2M2E3; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-12382569, EBI-11988865;
CC Q2M2E3; Q96EC8: YIPF6; NbExp=3; IntAct=EBI-12382569, EBI-751210;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in testis and sperm; especially localized
CC to sperm tail (at protein level). {ECO:0000269|PubMed:12728016}.
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DR EMBL; AB081120; BAC15594.1; -; mRNA.
DR EMBL; AY237799; AAO89569.1; -; mRNA.
DR EMBL; BC112010; AAI12011.1; -; mRNA.
DR EMBL; BC112014; AAI12015.1; -; mRNA.
DR CCDS; CCDS11140.1; -.
DR RefSeq; NP_694552.2; NM_153007.4.
DR AlphaFoldDB; Q2M2E3; -.
DR BioGRID; 127017; 26.
DR IntAct; Q2M2E3; 23.
DR STRING; 9606.ENSP00000331086; -.
DR iPTMnet; Q2M2E3; -.
DR PhosphoSitePlus; Q2M2E3; -.
DR BioMuta; ODF4; -.
DR DMDM; 158564291; -.
DR PaxDb; Q2M2E3; -.
DR PRIDE; Q2M2E3; -.
DR Antibodypedia; 42968; 54 antibodies from 14 providers.
DR DNASU; 146852; -.
DR Ensembl; ENST00000328248.7; ENSP00000331086.2; ENSG00000184650.11.
DR GeneID; 146852; -.
DR KEGG; hsa:146852; -.
DR MANE-Select; ENST00000328248.7; ENSP00000331086.2; NM_153007.5; NP_694552.2.
DR UCSC; uc002gle.2; human.
DR CTD; 146852; -.
DR DisGeNET; 146852; -.
DR GeneCards; ODF4; -.
DR HGNC; HGNC:19056; ODF4.
DR HPA; ENSG00000184650; Tissue enriched (testis).
DR MIM; 610097; gene.
DR neXtProt; NX_Q2M2E3; -.
DR OpenTargets; ENSG00000184650; -.
DR PharmGKB; PA134978853; -.
DR VEuPathDB; HostDB:ENSG00000184650; -.
DR eggNOG; ENOG502SXVG; Eukaryota.
DR GeneTree; ENSGT00940000163675; -.
DR HOGENOM; CLU_062754_1_0_1; -.
DR InParanoid; Q2M2E3; -.
DR OMA; RWPVDVS; -.
DR OrthoDB; 1432634at2759; -.
DR PhylomeDB; Q2M2E3; -.
DR TreeFam; TF338228; -.
DR PathwayCommons; Q2M2E3; -.
DR SignaLink; Q2M2E3; -.
DR BioGRID-ORCS; 146852; 11 hits in 1053 CRISPR screens.
DR GenomeRNAi; 146852; -.
DR Pharos; Q2M2E3; Tbio.
DR PRO; PR:Q2M2E3; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q2M2E3; protein.
DR Bgee; ENSG00000184650; Expressed in left testis and 43 other tissues.
DR ExpressionAtlas; Q2M2E3; baseline and differential.
DR Genevisible; Q2M2E3; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; Membrane; Phosphoprotein;
KW Reference proteome; Spermatogenesis; Transmembrane; Transmembrane helix.
FT CHAIN 1..257
FT /note="Outer dense fiber protein 4"
FT /id="PRO_0000304722"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..32
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 64
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8VI88"
FT VARIANT 34
FT /note="W -> R (in dbSNP:rs12943505)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_035060"
FT VARIANT 98
FT /note="V -> M (in dbSNP:rs12601097)"
FT /evidence="ECO:0000269|PubMed:12728016,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2"
FT /id="VAR_035061"
FT VARIANT 139
FT /note="Y -> C (in dbSNP:rs12936935)"
FT /evidence="ECO:0000269|PubMed:12728016,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2"
FT /id="VAR_035062"
SQ SEQUENCE 257 AA; 29233 MW; B0E743E89798BA39 CRC64;
MDAEYSGNEF PRSEGERDQH QRPGKERKSG EAGWGTGELG QDGRLLSSTL SLSSNRSLGQ
RQNSPLPFQW RITHSFRWMA QVLASELSLV AFILLLVVAF SKKWLDLSRS LFYQRWPVDV
SNRIHTSAHV MSMGLLHFYK SRSCSDLENG KVTFIFSTLM LFPINIWIFE LERNVSIPIG
WSYFIGWLVL ILYFTCAILC YFNHKSFWSL ILSHPSGAVS CSSSFGSVEE SPRAQTITDT
PITQEGVLDP EQKDTHV
