ID   ODHI_CORDI              Reviewed;         143 AA.
AC   Q6NHD4;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Oxoglutarate dehydrogenase inhibitor;
GN   Name=odhI; OrderedLocusNames=DIP1204;
OS   Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype
OS   gravis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=257309;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700971 / NCTC 13129 / Biotype gravis;
RX   PubMed=14602910; DOI=10.1093/nar/gkg874;
RA   Cerdeno-Tarraga A.-M., Efstratiou A., Dover L.G., Holden M.T.G.,
RA   Pallen M.J., Bentley S.D., Besra G.S., Churcher C.M., James K.D.,
RA   De Zoysa A., Chillingworth T., Cronin A., Dowd L., Feltwell T., Hamlin N.,
RA   Holroyd S., Jagels K., Moule S., Quail M.A., Rabbinowitsch E.,
RA   Rutherford K.M., Thomson N.R., Unwin L., Whitehead S., Barrell B.G.,
RA   Parkhill J.;
RT   "The complete genome sequence and analysis of Corynebacterium diphtheriae
RT   NCTC13129.";
RL   Nucleic Acids Res. 31:6516-6523(2003).
CC   -!- FUNCTION: An essential component of the PknG signaling pathway. When
CC       unphosphorylated, it inhibits the activity of 2-oxoglutarate
CC       dehydrogenase. When phosphorylated it does not inhibit 2-oxoglutarate
CC       dehydrogenase (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
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DR   EMBL; BX248357; CAE49731.1; -; Genomic_DNA.
DR   RefSeq; WP_010934889.1; NC_002935.2.
DR   AlphaFoldDB; Q6NHD4; -.
DR   SMR; Q6NHD4; -.
DR   STRING; 257309.DIP1204; -.
DR   EnsemblBacteria; CAE49731; CAE49731; DIP1204.
DR   GeneID; 29421405; -.
DR   KEGG; cdi:DIP1204; -.
DR   HOGENOM; CLU_108862_1_0_11; -.
DR   OMA; IGKFRLT; -.
DR   OrthoDB; 1632705at2; -.
DR   Proteomes; UP000002198; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   CDD; cd00060; FHA; 1.
DR   InterPro; IPR000253; FHA_dom.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   Pfam; PF00498; FHA; 1.
DR   SMART; SM00240; FHA; 1.
DR   SUPFAM; SSF49879; SSF49879; 1.
DR   PROSITE; PS50006; FHA_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Phosphoprotein; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..143
FT                   /note="Oxoglutarate dehydrogenase inhibitor"
FT                   /id="PRO_0000272963"
FT   DOMAIN          68..117
FT                   /note="FHA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00086"
FT   REGION          29..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         14
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   143 AA;  15264 MW;  7BE05BBB76F8DB1F CRC64;
     MSDNTGAPDV QVETTSVFRA DLLKEMESGA GAATASGSDV TPPAGAGMLV VKRGPNAGAR
     FLLDRPTTTA GRHPESDIFL DDVTVSRRHA EFRRQDGSFE VVDVGSLNGT YVNREPRNSE
     VLSSGDEVQI GKFRLVFIEG PRA