ID   ODHI_COREF              Reviewed;         142 AA.
AC   Q8FTJ5;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Oxoglutarate dehydrogenase inhibitor;
GN   Name=odhI; OrderedLocusNames=CE1573;
OS   Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189
OS   / NBRC 100395).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=196164;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395;
RX   PubMed=12840036; DOI=10.1101/gr.1285603;
RA   Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S.,
RA   Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.;
RT   "Comparative complete genome sequence analysis of the amino acid
RT   replacements responsible for the thermostability of Corynebacterium
RT   efficiens.";
RL   Genome Res. 13:1572-1579(2003).
CC   -!- FUNCTION: An essential component of the PknG signaling pathway. When
CC       unphosphorylated, it inhibits the activity of 2-oxoglutarate
CC       dehydrogenase. When phosphorylated it does not inhibit 2-oxoglutarate
CC       dehydrogenase (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
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DR   EMBL; BA000035; BAC18383.1; -; Genomic_DNA.
DR   RefSeq; WP_006767572.1; NZ_GG700683.1.
DR   AlphaFoldDB; Q8FTJ5; -.
DR   SMR; Q8FTJ5; -.
DR   STRING; 196164.23493413; -.
DR   PRIDE; Q8FTJ5; -.
DR   EnsemblBacteria; BAC18383; BAC18383; BAC18383.
DR   KEGG; cef:CE1573; -.
DR   eggNOG; COG1716; Bacteria.
DR   HOGENOM; CLU_108862_1_0_11; -.
DR   OMA; IGKFRLT; -.
DR   OrthoDB; 1632705at2; -.
DR   Proteomes; UP000001409; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   CDD; cd00060; FHA; 1.
DR   InterPro; IPR000253; FHA_dom.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   Pfam; PF00498; FHA; 1.
DR   SMART; SM00240; FHA; 1.
DR   SUPFAM; SSF49879; SSF49879; 1.
DR   PROSITE; PS50006; FHA_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Phosphoprotein; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..142
FT                   /note="Oxoglutarate dehydrogenase inhibitor"
FT                   /id="PRO_0000272964"
FT   DOMAIN          67..116
FT                   /note="FHA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00086"
FT   MOD_RES         14
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   142 AA;  15096 MW;  97C64454E33A1238 CRC64;
     MSDNTGTPEP QVETTSVFRA DLLKEMSGAG SAPAATGADN LPAGSALLVV KRGPNAGARF
     LLDQPTTTAG RHPESDIFLD DVTVSRRHAE FRINEGEFEV VDVGSLNGTY VNREPRNSQV
     LQTGDEIQIG KFRLVFLAGP AA