ID   ARSD1_ECOLX             Reviewed;         120 AA.
AC   P46003;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 2.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Arsenical resistance operon trans-acting repressor ArsD;
GN   Name=arsD;
OS   Escherichia coli.
OG   Plasmid R773.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8326869; DOI=10.1111/j.1365-2958.1993.tb01605.x;
RA   Wu J., Rosen B.P.;
RT   "The arsD gene encodes a second trans-acting regulatory protein of the
RT   plasmid-encoded arsenical resistance operon.";
RL   Mol. Microbiol. 8:615-623(1993).
RN   [2]
RP   SEQUENCE REVISION.
RA   Wu J., Rosen B.P.;
RL   Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inducer-independent trans-acting repressor of the ars operon.
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DR   EMBL; U13073; AAA93060.1; -; Genomic_DNA.
DR   PDB; 3KGK; X-ray; 1.40 A; A/B=1-109.
DR   PDB; 3MWH; X-ray; 2.05 A; A/B=1-109.
DR   PDBsum; 3KGK; -.
DR   PDBsum; 3MWH; -.
DR   AlphaFoldDB; P46003; -.
DR   BMRB; P46003; -.
DR   SMR; P46003; -.
DR   DIP; DIP-16987N; -.
DR   BioCyc; MetaCyc:MON-21686; -.
DR   EvolutionaryTrace; P46003; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0046685; P:response to arsenic-containing substance; IEA:UniProtKB-KW.
DR   InterPro; IPR010712; Arsenical-R_ArsD.
DR   Pfam; PF06953; ArsD; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Arsenical resistance; DNA-binding; Plasmid; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..120
FT                   /note="Arsenical resistance operon trans-acting repressor
FT                   ArsD"
FT                   /id="PRO_0000064662"
FT   STRAND          4..8
FT                   /evidence="ECO:0007829|PDB:3KGK"
FT   HELIX           25..39
FT                   /evidence="ECO:0007829|PDB:3KGK"
FT   STRAND          43..47
FT                   /evidence="ECO:0007829|PDB:3KGK"
FT   TURN            48..50
FT                   /evidence="ECO:0007829|PDB:3KGK"
FT   HELIX           54..57
FT                   /evidence="ECO:0007829|PDB:3KGK"
FT   HELIX           59..68
FT                   /evidence="ECO:0007829|PDB:3KGK"
FT   HELIX           70..72
FT                   /evidence="ECO:0007829|PDB:3KGK"
FT   STRAND          75..78
FT                   /evidence="ECO:0007829|PDB:3KGK"
FT   STRAND          81..87
FT                   /evidence="ECO:0007829|PDB:3KGK"
FT   HELIX           91..98
FT                   /evidence="ECO:0007829|PDB:3KGK"
SQ   SEQUENCE   120 AA;  12927 MW;  DFE88565FABDD9AE CRC64;
     MKTLMVFDPA MCCSTGVCGT DVDQALVDFS TDVQWLKQCG VQIERFNLAQ QPMSFVQNEK
     VKAFIEASGA EGLPLLLLDG ETVMAGRYPK RAELARWFGI PLDKVGLAPS GCCGGNTSCC