ID   A28_MYXVU               Reviewed;         140 AA.
AC   P68549; Q83657;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Envelope protein A28 homolog;
DE   AltName: Full=MA28;
GN   OrderedLocusNames=MA28L;
OS   Myxoma virus (strain Uriarra) (MYXV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Leporipoxvirus.
OX   NCBI_TaxID=265876;
OH   NCBI_TaxID=9986; Oryctolagus cuniculus (Rabbit).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8758001; DOI=10.1099/0022-1317-77-7-1569;
RA   Jackson R.J., Hall D.F., Kerr P.J.;
RT   "Construction of recombinant myxoma viruses expressing foreign genes from
RT   different intergenic sites without associated attenuation.";
RL   J. Gen. Virol. 77:1569-1575(1996).
CC   -!- FUNCTION: Envelope protein required for virus entry into host cell and
CC       for cell-cell fusion (syncytium formation). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass type
CC       II membrane protein {ECO:0000305}. Note=Component of the intracellular
CC       mature virion (IMV) membrane. {ECO:0000250}.
CC   -!- PTM: Contains two intramolecular disulfide bonds. They are created by
CC       the viral disulfide bond formation pathway, a poxvirus-specific pathway
CC       that operates on the cytoplasmic side of the MV membranes (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae A28 protein family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z19600; CAA79662.1; -; Genomic_DNA.
DR   PIR; S31628; S31628.
DR   RefSeq; NP_051830.1; NC_001132.2.
DR   GeneID; 932155; -.
DR   KEGG; vg:932155; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0039663; P:membrane fusion involved in viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR007664; Poxvirus_A28.
DR   Pfam; PF04584; Pox_A28; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Fusion of virus membrane with host membrane; Late protein;
KW   Membrane; Signal-anchor; Transmembrane; Transmembrane helix;
KW   Viral envelope protein; Viral penetration into host cytoplasm; Virion;
KW   Virus entry into host cell.
FT   CHAIN           1..140
FT                   /note="Envelope protein A28 homolog"
FT                   /id="PRO_0000099296"
FT   TRANSMEM        1..21
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        22..140
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   140 AA;  16036 MW;  F6940309C4F0E218 CRC64;
     MNPVTVFFVV VVTVAVCMIL FQVYSIYLNY DNIKEFNAMH SPLEYSKMVN VTAIDRRVQD
     ANDDIYDAKQ KWRCVKFDDS YVSLSMFGYK ADGVGIRRFR TLNGCIDYTF STSTHSSILN
     PCIPPNDPKS RECTFLKSAL