ODR10_CAEEL
ID ODR10_CAEEL Reviewed; 339 AA.
AC Q18807; Q17376;
DT 09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 3.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Serpentine receptor class r-10;
DE AltName: Full=Odorant response abnormal protein 10;
DE AltName: Full=Olfactory receptor 10;
GN Name=odr-10 {ECO:0000312|WormBase:C53B7.5};
GN ORFNames=C53B7.5 {ECO:0000312|WormBase:C53B7.5};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAB00117.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, INDUCTION, DISRUPTION PHENOTYPE, AND MUTAGENESIS OF HIS-110.
RC STRAIN=Bristol N2 {ECO:0000269|PubMed:8601313};
RX PubMed=8601313; DOI=10.1016/s0092-8674(00)81068-5;
RA Sengupta P., Chou J.H., Bargmann C.I.;
RT "odr-10 encodes a seven transmembrane domain olfactory receptor required
RT for responses to the odorant diacetyl.";
RL Cell 84:899-909(1996).
RN [2] {ECO:0000312|EMBL:ACQ44039.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=AB3 {ECO:0000312|EMBL:ACQ44039.1}, BO {ECO:0000312|EMBL:ACQ44040.1},
RC CB4855 {ECO:0000312|EMBL:ACQ44050.1}, CB4856 {ECO:0000312|EMBL:ACQ44041.1},
RC CB4857 {ECO:0000312|EMBL:ACQ44042.1}, CB4932 {ECO:0000312|EMBL:ACQ44043.1},
RC DH424 {ECO:0000312|EMBL:ACQ44049.1}, PX174 {ECO:0000312|EMBL:ACQ44045.1},
RC PX178 {ECO:0000312|EMBL:ACQ44044.1}, PX179 {ECO:0000312|EMBL:ACQ44046.1},
RC RC301 {ECO:0000312|EMBL:ACQ44047.1}, and
RC TR403 {ECO:0000312|EMBL:ACQ44048.1};
RX PubMed=19001295; DOI=10.1534/genetics.107.082651;
RA Jovelin R., Dunham J.P., Sung F.S., Phillips P.C.;
RT "High nucleotide divergence in developmental regulatory genes contrasts
RT with the structural elements of olfactory pathways in caenorhabditis.";
RL Genetics 181:1387-1397(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [4] {ECO:0000305}
RP FUNCTION.
RX PubMed=10421632; DOI=10.1101/gad.13.14.1794;
RA Sagasti A., Hobert O., Troemel E.R., Ruvkun G., Bargmann C.I.;
RT "Alternative olfactory neuron fates are specified by the LIM homeobox gene
RT lim-4.";
RL Genes Dev. 13:1794-1806(1999).
RN [5]
RP INTERACTION WITH ODR-4, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=24603482; DOI=10.1371/journal.pgen.1004082;
RA Chen C., Itakura E., Weber K.P., Hegde R.S., de Bono M.;
RT "An ER complex of ODR-4 and ODR-8/Ufm1 specific protease 2 promotes GPCR
RT maturation by a Ufm1-independent mechanism.";
RL PLoS Genet. 10:E1004082-E1004082(2014).
RN [6]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=26150102; DOI=10.1038/srep11855;
RA Xu Q., Zhang Y., Wei Q., Huang Y., Li Y., Ling K., Hu J.;
RT "BBS4 and BBS5 show functional redundancy in the BBSome to regulate the
RT degradative sorting of ciliary sensory receptors.";
RL Sci. Rep. 5:11855-11855(2015).
RN [7]
RP DEVELOPMENTAL STAGE.
RX PubMed=31264582; DOI=10.7554/elife.43660;
RA Lawson H., Vuong E., Miller R.M., Kiontke K., Fitch D.H., Portman D.S.;
RT "The Makorin lep-2 and the lncRNA lep-5 regulate lin-28 to schedule sexual
RT maturation of the C. elegans nervous system.";
RL Elife 8:0-0(2019).
CC -!- FUNCTION: An odorant receptor which affects chemotaxis to the volatile
CC odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7
CC pathway. {ECO:0000269|PubMed:10421632, ECO:0000269|PubMed:8601313}.
CC -!- SUBUNIT: Interacts with odr-4. {ECO:0000269|PubMed:24603482}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000269|PubMed:24603482, ECO:0000269|PubMed:26150102,
CC ECO:0000269|PubMed:8601313}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:24603482, ECO:0000269|PubMed:8601313}.
CC -!- TISSUE SPECIFICITY: Strongly expressed in the sensory cilia of AWA
CC olfactory neurons, and at low levels in the CEP neurons.
CC {ECO:0000269|PubMed:24603482, ECO:0000269|PubMed:26150102,
CC ECO:0000269|PubMed:8601313}.
CC -!- DEVELOPMENTAL STAGE: Expressed in AWA olfactory neurons at the L3
CC larval stage in males and hermaphrodites, but expressed decreases in
CC males from the L4 stage to adulthood. {ECO:0000269|PubMed:31264582}.
CC -!- INDUCTION: Induced upon exposure to the volatile odorant diacetyl.
CC {ECO:0000269|PubMed:8601313}.
CC -!- DISRUPTION PHENOTYPE: Defective response to diacetyl with wild-type
CC response exhibited to other ketones and odorants sensed by AWA.
CC {ECO:0000269|PubMed:8601313}.
CC -!- SIMILARITY: Belongs to the nematode receptor-like protein str family.
CC {ECO:0000255}.
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DR EMBL; U49449; AAB00117.1; -; mRNA.
DR EMBL; FJ455649; ACQ44039.1; -; Genomic_DNA.
DR EMBL; FJ455650; ACQ44040.1; -; Genomic_DNA.
DR EMBL; FJ455651; ACQ44041.1; -; Genomic_DNA.
DR EMBL; FJ455652; ACQ44042.1; -; Genomic_DNA.
DR EMBL; FJ455653; ACQ44043.1; -; Genomic_DNA.
DR EMBL; FJ455654; ACQ44044.1; -; Genomic_DNA.
DR EMBL; FJ455655; ACQ44045.1; -; Genomic_DNA.
DR EMBL; FJ455656; ACQ44046.1; -; Genomic_DNA.
DR EMBL; FJ455657; ACQ44047.1; -; Genomic_DNA.
DR EMBL; FJ455658; ACQ44048.1; -; Genomic_DNA.
DR EMBL; FJ455659; ACQ44049.1; -; Genomic_DNA.
DR EMBL; FJ455660; ACQ44050.1; -; Genomic_DNA.
DR EMBL; BX284606; CCD67888.1; -; Genomic_DNA.
DR PIR; T28806; T28806.
DR RefSeq; NP_509157.1; NM_076756.3.
DR AlphaFoldDB; Q18807; -.
DR SMR; Q18807; -.
DR BioGRID; 45887; 5.
DR STRING; 6239.C53B7.5; -.
DR TCDB; 9.A.14.24.1; the g-protein-coupled receptor (gpcr) family.
DR PaxDb; Q18807; -.
DR EnsemblMetazoa; C53B7.5.1; C53B7.5.1; WBGene00003856.
DR GeneID; 180959; -.
DR KEGG; cel:CELE_C53B7.5; -.
DR UCSC; C53B7.5; c. elegans.
DR CTD; 180959; -.
DR WormBase; C53B7.5; CE26361; WBGene00003856; odr-10.
DR eggNOG; ENOG502TFTY; Eukaryota.
DR GeneTree; ENSGT00970000196747; -.
DR HOGENOM; CLU_036335_2_1_1; -.
DR InParanoid; Q18807; -.
DR OMA; MWASVSY; -.
DR OrthoDB; 954390at2759; -.
DR PhylomeDB; Q18807; -.
DR PRO; PR:Q18807; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00003856; Expressed in larva and 1 other tissue.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030425; C:dendrite; IDA:WormBase.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:WormBase.
DR GO; GO:0043025; C:neuronal cell body; IDA:WormBase.
DR GO; GO:0097730; C:non-motile cilium; IDA:WormBase.
DR GO; GO:1990075; C:periciliary membrane compartment; IDA:WormBase.
DR GO; GO:0038022; F:G protein-coupled olfactory receptor activity; IDA:WormBase.
DR GO; GO:0004930; F:G protein-coupled receptor activity; ISM:WormBase.
DR GO; GO:0001965; F:G-protein alpha-subunit binding; IPI:WormBase.
DR GO; GO:0050907; P:detection of chemical stimulus involved in sensory perception; IMP:WormBase.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:WormBase.
DR GO; GO:0042048; P:olfactory behavior; IDA:WormBase.
DR GO; GO:0050918; P:positive chemotaxis; IMP:WormBase.
DR InterPro; IPR019428; 7TM_GPCR_serpentine_rcpt_Str.
DR Pfam; PF10326; 7TM_GPCR_Str; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cell projection; Chemotaxis; Cilium; Glycoprotein; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..339
FT /note="Serpentine receptor class r-10"
FT /id="PRO_0000391384"
FT TOPO_DOM 1..11
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 12..32
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 33..42
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 64..92
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..131
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 153..201
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..254
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 255..275
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 276..284
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..305
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 306..339
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 71
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 83
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 179
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT MUTAGEN 110
FT /note="H->Y: Defective in their response to diacetyl but
FT wild type response to other odorants."
FT /evidence="ECO:0000269|PubMed:8601313"
SQ SEQUENCE 339 AA; 39227 MW; 89AA9FE6C7644BAC CRC64;
MSGELWITLV DTADIVGVTL TFCVNIVLLG LLKTRGKNLG TYKYLMAFFS VFSIFYAIIE
FILRPIMHIE NTTFFLISRK RFNYSTKLGK INSAFYCACF ATSFVVSGVH FVYRYFATCK
PNLLRLFNLP TLLLWPLGCS VPVTMWASVS YFLYPDTEYT EAAVTNVLNN HYNWIKKENV
SYIAYVYYQY ENGVRHIYLK NLLGCFVHYF VMSMTFVVMF YCGYATWKTM NEHKDVSDRT
RALQKQLFKA LVLQTLIPTI FMYAPTGVMF IAPFFDVNLN ANANFIVFCS FLYPGLDPLI
LILIIRDFRR TIFNFLCGKK NSVDESRSTT RANLSQVPT
