ODR4_CAEEL
ID ODR4_CAEEL Reviewed; 475 AA.
AC Q8I7F8; O61648; Q23233; Q8I7F7;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 118.
DE RecName: Full=Odorant response abnormal protein 4;
GN Name=odr-4; ORFNames=Y102E9.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, SUBCELLULAR LOCATION,
RP TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RC STRAIN=Bristol N2;
RX PubMed=9590179; DOI=10.1016/s0092-8674(00)81173-3;
RA Dwyer N.D., Troemel E.R., Sengupta P., Bargmann C.I.;
RT "Odorant receptor localization to olfactory cilia is mediated by ODR-4, a
RT novel membrane-associated protein.";
RL Cell 93:455-466(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP FUNCTION.
RX PubMed=8348618; DOI=10.1016/0092-8674(93)80053-h;
RA Bargmann C.I., Hartwieg E., Horvitz H.R.;
RT "Odorant-selective genes and neurons mediate olfaction in C. elegans.";
RL Cell 74:515-527(1993).
RN [4]
RP FUNCTION.
RX PubMed=16581509; DOI=10.1016/j.cub.2006.03.023;
RA Rogers C., Persson A., Cheung B., de Bono M.;
RT "Behavioral motifs and neural pathways coordinating O2 responses and
RT aggregation in C. elegans.";
RL Curr. Biol. 16:649-659(2006).
RN [5]
RP FUNCTION, INTERACTION WITH ODR-8 AND ODR-10, SUBCELLULAR LOCATION, AND
RP TISSUE SPECIFICITY.
RX PubMed=24603482; DOI=10.1371/journal.pgen.1004082;
RA Chen C., Itakura E., Weber K.P., Hegde R.S., de Bono M.;
RT "An ER complex of ODR-4 and ODR-8/Ufm1 specific protease 2 promotes GPCR
RT maturation by a Ufm1-independent mechanism.";
RL PLoS Genet. 10:E1004082-E1004082(2014).
CC -!- FUNCTION: Required, with oct-8, for the localization of a subset of 7
CC transmembrane domain odorant receptors, including odr-10, to the cilia
CC of olfactory neurons AWA and AWC (PubMed:9590179, PubMed:24603482).
CC Regulates chemotaxis responses to benzaldehyde, diacetyl and 2,4,5-
CC trimethylthiazole in AWA and AWC neurons (PubMed:8348618). Plays a role
CC in nociceptive neurons to mediate avoidance of high oxygen
CC (PubMed:16581509). {ECO:0000269|PubMed:16581509,
CC ECO:0000269|PubMed:24603482, ECO:0000269|PubMed:8348618,
CC ECO:0000269|PubMed:9590179}.
CC -!- SUBUNIT: Interacts with odr-8 and odr-10.
CC {ECO:0000269|PubMed:24603482}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC membrane protein. Golgi apparatus membrane; Multi-pass membrane
CC protein. Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass
CC membrane protein. Cell projection, dendrite. Cell projection, axon.
CC Note=Punctate expression in dendrite and axons.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=b;
CC IsoId=Q8I7F8-1; Sequence=Displayed;
CC Name=a;
CC IsoId=Q8I7F8-2; Sequence=VSP_038345, VSP_038346;
CC Name=c;
CC IsoId=Q8I7F8-3; Sequence=VSP_028104;
CC -!- TISSUE SPECIFICITY: Expressed in the amphid head neurons AWA, AWC, AWB,
CC ADF, ADL, ASG, ASH, ASI, ASJ, and ASK, and in the phasmid tail neurons,
CC PHA and PHB. {ECO:0000269|PubMed:24603482, ECO:0000269|PubMed:9590179}.
CC -!- DEVELOPMENTAL STAGE: Expression is seen from 3-fold embryonic stage
CC onward.
CC -!- DISRUPTION PHENOTYPE: Failure to localize the diacetyl receptor odr-10.
CC {ECO:0000269|PubMed:9590179}.
CC -!- SIMILARITY: Belongs to the ODR-4 family. {ECO:0000305}.
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DR EMBL; AF055911; AAC39022.1; -; mRNA.
DR EMBL; FO081313; CCD70711.1; -; Genomic_DNA.
DR EMBL; FO081313; CCD70712.1; -; Genomic_DNA.
DR EMBL; FO081313; CCD70713.1; -; Genomic_DNA.
DR PIR; T26373; T26373.
DR PIR; T43002; T43002.
DR RefSeq; NP_001022814.1; NM_001027643.2. [Q8I7F8-1]
DR RefSeq; NP_001022815.1; NM_001027644.5. [Q8I7F8-3]
DR RefSeq; NP_498477.1; NM_066076.5.
DR AlphaFoldDB; Q8I7F8; -.
DR SMR; Q8I7F8; -.
DR BioGRID; 41165; 3.
DR DIP; DIP-24586N; -.
DR STRING; 6239.Y102E9.1b; -.
DR EPD; Q8I7F8; -.
DR PaxDb; Q8I7F8; -.
DR PeptideAtlas; Q8I7F8; -.
DR EnsemblMetazoa; Y102E9.1a.1; Y102E9.1a.1; WBGene00003851. [Q8I7F8-2]
DR EnsemblMetazoa; Y102E9.1a.2; Y102E9.1a.2; WBGene00003851. [Q8I7F8-2]
DR EnsemblMetazoa; Y102E9.1a.3; Y102E9.1a.3; WBGene00003851. [Q8I7F8-2]
DR EnsemblMetazoa; Y102E9.1a.4; Y102E9.1a.4; WBGene00003851. [Q8I7F8-2]
DR EnsemblMetazoa; Y102E9.1b.1; Y102E9.1b.1; WBGene00003851. [Q8I7F8-1]
DR EnsemblMetazoa; Y102E9.1c.1; Y102E9.1c.1; WBGene00003851. [Q8I7F8-3]
DR GeneID; 175950; -.
DR KEGG; cel:CELE_Y102E9.1; -.
DR UCSC; Y102E9.1b; c. elegans. [Q8I7F8-1]
DR CTD; 175950; -.
DR WormBase; Y102E9.1a; CE28101; WBGene00003851; odr-4. [Q8I7F8-2]
DR WormBase; Y102E9.1b; CE32953; WBGene00003851; odr-4. [Q8I7F8-1]
DR WormBase; Y102E9.1c; CE32954; WBGene00003851; odr-4. [Q8I7F8-3]
DR eggNOG; KOG4703; Eukaryota.
DR InParanoid; Q8I7F8; -.
DR OMA; IDEGWER; -.
DR OrthoDB; 1624689at2759; -.
DR PhylomeDB; Q8I7F8; -.
DR PRO; PR:Q8I7F8; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00003851; Expressed in material anatomical entity and 5 other tissues.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:WormBase.
DR GO; GO:0032991; C:protein-containing complex; IDA:WormBase.
DR GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007635; P:chemosensory behavior; IMP:WormBase.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR GO; GO:0042048; P:olfactory behavior; IMP:UniProtKB.
DR GO; GO:0008104; P:protein localization; IMP:WormBase.
DR GO; GO:0097499; P:protein localization to non-motile cilium; IMP:WormBase.
DR GO; GO:0097500; P:receptor localization to non-motile cilium; IMP:WormBase.
DR GO; GO:1990834; P:response to odorant; IMP:UniProtKB.
DR GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
DR InterPro; IPR029454; ODR-4-like.
DR PANTHER; PTHR33966; PTHR33966; 1.
DR Pfam; PF14778; ODR4-like; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell projection; Chemotaxis; Cytoplasmic vesicle;
KW Endoplasmic reticulum; Golgi apparatus; Membrane; Olfaction;
KW Reference proteome; Sensory transduction; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..475
FT /note="Odorant response abnormal protein 4"
FT /id="PRO_0000304689"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 453..473
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..32
FT /note="Missing (in isoform a)"
FT /evidence="ECO:0000303|PubMed:9590179"
FT /id="VSP_038345"
FT VAR_SEQ 28..29
FT /note="Missing (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_028104"
FT VAR_SEQ 289
FT /note="Y -> FLD (in isoform a)"
FT /evidence="ECO:0000303|PubMed:9590179"
FT /id="VSP_038346"
SQ SEQUENCE 475 AA; 53697 MW; A08EAE8B8CA0FA52 CRC64;
MTRNRRKSKT TATSHPELHL EKVDPMKTVT ESMILFDVQL QEWVTKSAKN HEFVLSDKGI
PASAYFLLGS FCSDGDIHVA YASKCPVHSS ALEENATESS KMLEDEWMSD HAERLLRMLP
GGIHVVGIAW FSDKKTFSDR KSHIHKTLGR IQKMNNQITT ANVDDSISDN MITVFFETPS
TTPIGAIIDV TNRGNDSAQK VQFQKLEWIS LVTNASARIV HNVPVDTGRP TDFYSDLVVA
TKNFVNNLFQ CEFTLLDGEI RDDKEPLIKD IKKNKKTTIE AQLFLNPLYN RELGAIDDIA
SNMHEVLFDI EVRAAVPIRS TVKDAIRAIK HHLVRNLFAR VELHYESMEV VEEERSPKTG
ITVHQLPRPA TTVLYTHPAI LINDFLFEAD NVEDAQKNFD DMMDLQTSIE HVDEGWERAL
TPEEMEAVRT PIEDLHFVDF DGSSDSWCTT KTILITIALI IGLLASIIYF TVAHS
