ODR4_DROME
ID ODR4_DROME Reviewed; 492 AA.
AC Q9VTX8;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Protein odr-4 homolog;
GN ORFNames=CG10616;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- FUNCTION: May play a role in the trafficking of a subset of G-protein
CC coupled receptors. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ODR-4 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE014296; AAF49917.2; -; Genomic_DNA.
DR RefSeq; NP_001287048.1; NM_001300119.1.
DR RefSeq; NP_648576.1; NM_140319.3.
DR AlphaFoldDB; Q9VTX8; -.
DR BioGRID; 64770; 11.
DR DIP; DIP-18545N; -.
DR IntAct; Q9VTX8; 7.
DR STRING; 7227.FBpp0301023; -.
DR PaxDb; Q9VTX8; -.
DR PRIDE; Q9VTX8; -.
DR DNASU; 39420; -.
DR EnsemblMetazoa; FBtr0075956; FBpp0075688; FBgn0036286.
DR EnsemblMetazoa; FBtr0346569; FBpp0312167; FBgn0036286.
DR GeneID; 39420; -.
DR KEGG; dme:Dmel_CG10616; -.
DR UCSC; CG10616-RA; d. melanogaster.
DR FlyBase; FBgn0036286; CG10616.
DR VEuPathDB; VectorBase:FBgn0036286; -.
DR eggNOG; KOG4703; Eukaryota.
DR HOGENOM; CLU_554629_0_0_1; -.
DR InParanoid; Q9VTX8; -.
DR OMA; TKSIVVH; -.
DR OrthoDB; 1624689at2759; -.
DR PhylomeDB; Q9VTX8; -.
DR BioGRID-ORCS; 39420; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 39420; -.
DR PRO; PR:Q9VTX8; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0036286; Expressed in testis and 25 other tissues.
DR ExpressionAtlas; Q9VTX8; baseline and differential.
DR Genevisible; Q9VTX8; DM.
DR GO; GO:0012505; C:endomembrane system; HDA:FlyBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR InterPro; IPR029454; ODR-4-like.
DR PANTHER; PTHR33966; PTHR33966; 1.
DR Pfam; PF14778; ODR4-like; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..492
FT /note="Protein odr-4 homolog"
FT /id="PRO_0000304690"
FT TRANSMEM 469..489
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 251..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 492 AA; 54587 MW; 9B33DDCA59FDC05F CRC64;
MRTVLLSKHD ELYLEKCAQE NQFSYGIIVG HQADLTKSVV VHLARNNEED ADLEDLSEVR
LTISDINSQA LASQWLSASK MCPGSFDVIG IFVSSVRSDV VNEQSAEFKN AKKLFSDIYD
LLLKSNSSFG VYTTDIAQTD FVFLSYSLAD KKVLCKNYSY GNGGTFTNME FRFVDKPFEW
IQLECSYDFD DVLPILDSSR RVNIEDQFQS MIVSVRKNLL ASEVFLQNEV VEDTIDLQAY
IKKKKTKVDK LQPTSTTGGT ATASSNTTDS LPRLASEGII GGTETIRASI VLPMKCQLSK
PTDIKVREFS GTLHMSGIIT SKVFCNPRNS IADVKRFLRD DVLRSLITRI QVYCDGLTDP
YVTNEALYIS EPPRRVFFSL PSEGPSASVG AVVQFSEYLF RGEAPTVVVA QAKQILDVDL
DPETISVEAE GLPDDTHFNN CKMDADCIDD SGIMTSSMPK PELSRSLYMV GIAVALLVLL
SSVALHFVLA ER
