ODR4_HUMAN
ID ODR4_HUMAN Reviewed; 454 AA.
AC Q5SWX8; B4DNY0; E9PFR7; Q19CC6; Q8WYB6; Q9BTS2; Q9H6A6; Q9NX06;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Protein odr-4 homolog;
DE Short=hODR-4;
DE AltName: Full=LAG1-interacting protein;
DE AltName: Full=Transactivated by transforming growth factor beta protein 1;
GN Name=ODR4 {ECO:0000312|HGNC:HGNC:24299}; Synonyms=C1orf27, TTG1, TTG1A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC TISSUE=Brain;
RX PubMed=15718105; DOI=10.1016/j.ygeno.2004.11.009;
RA Lehman C.W., Lee J.D.R., Komives C.F.;
RT "Ubiquitously expressed GPCR membrane-trafficking orthologs.";
RL Genomics 85:386-391(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RA Xiao L., Cheng J., Hong Y.;
RT "Cloning of a gene transactivated by recombinant transforming growth factor
RT beta.";
RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 66-454 (ISOFORM 1), AND VARIANT CYS-251.
RC TISSUE=Lung, and Signet-ring cell carcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 368-454 (ISOFORMS 1/2).
RC TISSUE=Brain;
RA Pan H., Huo K.K., Li Y.Y.;
RT "Interactors of a human homolog of yeast LAG1 gene.";
RL Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- FUNCTION: May play a role in the trafficking of a subset of G-protein
CC coupled receptors. {ECO:0000250|UniProtKB:Q8I7F8}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q5SWX8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5SWX8-2; Sequence=VSP_028098;
CC Name=3;
CC IsoId=Q5SWX8-3; Sequence=VSP_028099, VSP_028100;
CC Name=4;
CC IsoId=Q5SWX8-4; Sequence=VSP_044478;
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC {ECO:0000269|PubMed:15718105}.
CC -!- SIMILARITY: Belongs to the ODR-4 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB15356.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY854248; AAW30011.1; -; mRNA.
DR EMBL; DQ323046; ABC50092.1; -; mRNA.
DR EMBL; DQ529299; ABF71985.1; -; mRNA.
DR EMBL; AK000512; BAA91218.1; -; mRNA.
DR EMBL; AK026086; BAB15356.1; ALT_INIT; mRNA.
DR EMBL; AK298107; BAG60392.1; -; mRNA.
DR EMBL; AL596220; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC003397; AAH03397.2; -; mRNA.
DR EMBL; AF214011; AAL56643.1; -; mRNA.
DR CCDS; CCDS53448.1; -. [Q5SWX8-1]
DR CCDS; CCDS53449.1; -. [Q5SWX8-2]
DR CCDS; CCDS53450.1; -. [Q5SWX8-4]
DR RefSeq; NP_001157717.1; NM_001164245.1. [Q5SWX8-2]
DR RefSeq; NP_001157718.1; NM_001164246.1. [Q5SWX8-4]
DR RefSeq; NP_060317.3; NM_017847.5. [Q5SWX8-1]
DR RefSeq; XP_011507962.1; XM_011509660.1. [Q5SWX8-1]
DR AlphaFoldDB; Q5SWX8; -.
DR BioGRID; 120291; 144.
DR IntAct; Q5SWX8; 11.
DR MINT; Q5SWX8; -.
DR STRING; 9606.ENSP00000287859; -.
DR GlyGen; Q5SWX8; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q5SWX8; -.
DR PhosphoSitePlus; Q5SWX8; -.
DR BioMuta; C1orf27; -.
DR DMDM; 74743951; -.
DR EPD; Q5SWX8; -.
DR jPOST; Q5SWX8; -.
DR MassIVE; Q5SWX8; -.
DR MaxQB; Q5SWX8; -.
DR PaxDb; Q5SWX8; -.
DR PeptideAtlas; Q5SWX8; -.
DR PRIDE; Q5SWX8; -.
DR ProteomicsDB; 63981; -. [Q5SWX8-1]
DR ProteomicsDB; 63982; -. [Q5SWX8-2]
DR ProteomicsDB; 63983; -. [Q5SWX8-3]
DR Antibodypedia; 3028; 63 antibodies from 15 providers.
DR DNASU; 54953; -.
DR Ensembl; ENST00000287859.11; ENSP00000287859.6; ENSG00000157181.16. [Q5SWX8-1]
DR Ensembl; ENST00000367470.8; ENSP00000356440.3; ENSG00000157181.16. [Q5SWX8-2]
DR Ensembl; ENST00000419367.8; ENSP00000395084.3; ENSG00000157181.16. [Q5SWX8-4]
DR GeneID; 54953; -.
DR KEGG; hsa:54953; -.
DR MANE-Select; ENST00000287859.11; ENSP00000287859.6; NM_017847.6; NP_060317.3.
DR UCSC; uc057nzb.1; human. [Q5SWX8-1]
DR CTD; 54953; -.
DR DisGeNET; 54953; -.
DR GeneCards; ODR4; -.
DR HGNC; HGNC:24299; ODR4.
DR HPA; ENSG00000157181; Low tissue specificity.
DR MIM; 609335; gene.
DR neXtProt; NX_Q5SWX8; -.
DR OpenTargets; ENSG00000157181; -.
DR PharmGKB; PA134934744; -.
DR VEuPathDB; HostDB:ENSG00000157181; -.
DR eggNOG; KOG4703; Eukaryota.
DR GeneTree; ENSGT00390000012568; -.
DR HOGENOM; CLU_043811_0_0_1; -.
DR InParanoid; Q5SWX8; -.
DR OMA; EMHWDSL; -.
DR OrthoDB; 1624689at2759; -.
DR PhylomeDB; Q5SWX8; -.
DR TreeFam; TF323772; -.
DR PathwayCommons; Q5SWX8; -.
DR SignaLink; Q5SWX8; -.
DR BioGRID-ORCS; 54953; 137 hits in 1079 CRISPR screens.
DR ChiTaRS; C1orf27; human.
DR GenomeRNAi; 54953; -.
DR Pharos; Q5SWX8; Tdark.
DR PRO; PR:Q5SWX8; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5SWX8; protein.
DR Bgee; ENSG00000157181; Expressed in corpus epididymis and 189 other tissues.
DR Genevisible; Q5SWX8; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR InterPro; IPR029454; ODR-4-like.
DR PANTHER; PTHR33966; PTHR33966; 1.
DR Pfam; PF14778; ODR4-like; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..454
FT /note="Protein odr-4 homolog"
FT /id="PRO_0000304683"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 432..452
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 79..110
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044478"
FT VAR_SEQ 238..260
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_028098"
FT VAR_SEQ 334..335
FT /note="DS -> RF (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_028099"
FT VAR_SEQ 336..454
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_028100"
FT VARIANT 251
FT /note="S -> C (in dbSNP:rs12084264)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_035059"
FT CONFLICT 51
FT /note="E -> G (in Ref. 2; ABF71985)"
FT /evidence="ECO:0000305"
FT CONFLICT 104
FT /note="F -> S (in Ref. 2; ABF71985)"
FT /evidence="ECO:0000305"
FT CONFLICT 158
FT /note="K -> E (in Ref. 2; ABF71985)"
FT /evidence="ECO:0000305"
FT CONFLICT 216
FT /note="E -> G (in Ref. 2; ABF71985)"
FT /evidence="ECO:0000305"
FT CONFLICT 358
FT /note="C -> R (in Ref. 2; ABF71985)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 454 AA; 51103 MW; 8D59C9136A4ED975 CRC64;
MGRTYIVEET VGQYLSNINL QGKAFVSGLL IGQCSSQKDY VILATRTPPK EEQSENLKHP
KAKLDNLDEE WATEHACQVS RMLPGGLLVL GVFIITTLEL ANDFQNALRR LMFAVEKSIN
RKRLWNFTEE EVSERVTLHI CASTKKIFCR TYDIHDPKSS ARPADWKYQS GLSSSWLSLE
CTVHINIHIP LSATSVSYTL EKNTKNGLTR WAKEIENGVY LINGQVKDED CDLLEGQKKS
SRGNTQATSH SFDVRVLTQL LLNSDHRSTA TVQICSGSVN LKGAVKCRAY IHSSKPKVKD
AVQAVKRDIL NTVADRCEML FEDLLLNEIP EKKDSEKEFH VLPYRVFVPL PGSTVMLCDY
KFDDESAEEI RDHFMEMLDH TIQIEDLEIA EETNTACMSS SMNSQASLDN TDDEQPKQPI
KTTMLLKIQQ NIGVIAAFTV AVLAAGISFH YFSD
