ODR4_MOUSE
ID ODR4_MOUSE Reviewed; 447 AA.
AC Q4PJX1; Q3U8Y3; Q99J66;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 2.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Protein odr-4 homolog;
DE Short=mODR-4;
GN Name=Odr4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=129/SvJ; TISSUE=Olfactory epithelium;
RA Pei X., Firestein S.;
RT "A C. elegans odr-4 homolog expressed in mouse olfactory sensory neurons.";
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=NMRI; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 34-447 (ISOFORM 3).
RC STRAIN=C57BL/6J; TISSUE=Bone marrow;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=15718105; DOI=10.1016/j.ygeno.2004.11.009;
RA Lehman C.W., Lee J.D.R., Komives C.F.;
RT "Ubiquitously expressed GPCR membrane-trafficking orthologs.";
RL Genomics 85:386-391(2005).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Liver, Pancreas, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play a role in the trafficking of a subset of G-protein
CC coupled receptors. {ECO:0000250|UniProtKB:Q8I7F8}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q4PJX1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q4PJX1-2; Sequence=VSP_028102;
CC Name=3;
CC IsoId=Q4PJX1-3; Sequence=VSP_028101;
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC {ECO:0000269|PubMed:15718105}.
CC -!- SIMILARITY: Belongs to the ODR-4 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE30884.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; DQ077804; AAY83272.2; -; mRNA.
DR EMBL; BC003331; AAH03331.2; -; mRNA.
DR EMBL; AK152022; BAE30884.1; ALT_INIT; mRNA.
DR CCDS; CCDS15355.2; -. [Q4PJX1-1]
DR CCDS; CCDS35733.1; -. [Q4PJX1-3]
DR RefSeq; NP_001070705.1; NM_001077237.1. [Q4PJX1-3]
DR RefSeq; NP_663486.2; NM_145511.2. [Q4PJX1-1]
DR AlphaFoldDB; Q4PJX1; -.
DR BioGRID; 230519; 2.
DR STRING; 10090.ENSMUSP00000107544; -.
DR iPTMnet; Q4PJX1; -.
DR PhosphoSitePlus; Q4PJX1; -.
DR SwissPalm; Q4PJX1; -.
DR EPD; Q4PJX1; -.
DR MaxQB; Q4PJX1; -.
DR PaxDb; Q4PJX1; -.
DR PeptideAtlas; Q4PJX1; -.
DR PRIDE; Q4PJX1; -.
DR ProteomicsDB; 289965; -. [Q4PJX1-1]
DR ProteomicsDB; 289966; -. [Q4PJX1-2]
DR ProteomicsDB; 289967; -. [Q4PJX1-3]
DR Antibodypedia; 3028; 63 antibodies from 15 providers.
DR DNASU; 226499; -.
DR Ensembl; ENSMUST00000006167; ENSMUSP00000006167; ENSMUSG00000006010. [Q4PJX1-2]
DR Ensembl; ENSMUST00000097546; ENSMUSP00000095152; ENSMUSG00000006010. [Q4PJX1-2]
DR Ensembl; ENSMUST00000097547; ENSMUSP00000095153; ENSMUSG00000006010. [Q4PJX1-3]
DR Ensembl; ENSMUST00000111913; ENSMUSP00000107544; ENSMUSG00000006010. [Q4PJX1-1]
DR GeneID; 226499; -.
DR KEGG; mmu:226499; -.
DR UCSC; uc007cxy.1; mouse. [Q4PJX1-2]
DR UCSC; uc007cxz.1; mouse. [Q4PJX1-1]
DR UCSC; uc007cya.1; mouse. [Q4PJX1-3]
DR CTD; 54953; -.
DR MGI; MGI:2385108; Odr4.
DR VEuPathDB; HostDB:ENSMUSG00000006010; -.
DR eggNOG; KOG4703; Eukaryota.
DR GeneTree; ENSGT00390000012568; -.
DR InParanoid; Q4PJX1; -.
DR OMA; EMHWDSL; -.
DR OrthoDB; 1624689at2759; -.
DR PhylomeDB; Q4PJX1; -.
DR TreeFam; TF323772; -.
DR BioGRID-ORCS; 226499; 18 hits in 73 CRISPR screens.
DR ChiTaRS; Odr4; mouse.
DR PRO; PR:Q4PJX1; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q4PJX1; protein.
DR Bgee; ENSMUSG00000006010; Expressed in supraoptic nucleus and 286 other tissues.
DR ExpressionAtlas; Q4PJX1; baseline and differential.
DR Genevisible; Q4PJX1; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR InterPro; IPR029454; ODR-4-like.
DR PANTHER; PTHR33966; PTHR33966; 1.
DR Pfam; PF14778; ODR4-like; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..447
FT /note="Protein odr-4 homolog"
FT /id="PRO_0000304684"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 425..445
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 206..237
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028101"
FT VAR_SEQ 238..259
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028102"
SQ SEQUENCE 447 AA; 49998 MW; DA39CCF80959B812 CRC64;
MGRTYIVEET VGQYLSSINL QGKPFVSGLL IGQCSSQKDY VILATRTPPK EEQNDKVKQP
RAKLDNLDEE WATEHASQVS RMLPGGLVVL GIFIITTLEL ADDFQNALRR LIFSMEKSMS
RKRLWDVTED EVSERVTLHI CSSTKKISCR TYDVQDPKSS ARPADWKYQS RVSASWLSLD
CTVHVNIHIP LSATSVSYTL EKNTKSGLTR WAKQIENGVY LINGQVKGND CDLLEGQKKS
RGNTQATAHS FDVRVLTQLL LNSDHRSTAT VQICSGSVNL RGNVKCRAYI HSNRPKVKDA
VQAVKRDILN TVADRCEILF EDLLLNEIPE KKNYELPQRV FVPLPGSTVM LCDYKFGDES
AEEIRDHFSE MLDHEIQIED LEIAEEVNTA CMTSSVNSEA SLTNTSEEQP EQPKKTIGVK
IQQNIGVIAA LAVAVLAAGI SFHYFSD
