ODR7_CAEEL
ID ODR7_CAEEL Reviewed; 457 AA.
AC P41933; C3U4U8; C3U4U9; C3U4V2;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Nuclear hormone receptor family member odr-7;
DE AltName: Full=Odorant response abnormal protein 7;
GN Name=odr-7; ORFNames=T18D3.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE, AND MUTAGENESIS OF GLY-340.
RC STRAIN=Bristol N2;
RX PubMed=8001144; DOI=10.1016/0092-8674(94)90028-0;
RA Sengupta P., Colbert H.A., Bargmann C.I.;
RT "The C. elegans gene odr-7 encodes an olfactory-specific member of the
RT nuclear receptor superfamily.";
RL Cell 79:971-980(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ASP-47; PRO-155 AND
RP PRO-165.
RC STRAIN=AB3, BO, CB4855, CB4856, CB4857, CB4932, DH424, PX174, PX178, PX179,
RC RC301, and TR403;
RX PubMed=19001295; DOI=10.1534/genetics.107.082651;
RA Jovelin R., Dunham J.P., Sung F.S., Phillips P.C.;
RT "High nucleotide divergence in developmental regulatory genes contrasts
RT with the structural elements of olfactory pathways in caenorhabditis.";
RL Genetics 181:1387-1397(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [4]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=8601313; DOI=10.1016/s0092-8674(00)81068-5;
RA Sengupta P., Chou J.H., Bargmann C.I.;
RT "odr-10 encodes a seven transmembrane domain olfactory receptor required
RT for responses to the odorant diacetyl.";
RL Cell 84:899-909(1996).
RN [5]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=10421632; DOI=10.1101/gad.13.14.1794;
RA Sagasti A., Hobert O., Troemel E.R., Ruvkun G., Bargmann C.I.;
RT "Alternative olfactory neuron fates are specified by the LIM homeobox gene
RT lim-4.";
RL Genes Dev. 13:1794-1806(1999).
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=11018015; DOI=10.1101/gad.832300;
RA Sarafi-Reinach T.R., Sengupta P.;
RT "The forkhead domain gene unc-130 generates chemosensory neuron diversity
RT in C. elegans.";
RL Genes Dev. 14:2472-2485(2000).
RN [7]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=11546744; DOI=10.1242/dev.128.17.3269;
RA Sarafi-Reinach T.R., Melkman T., Hobert O., Sengupta P.;
RT "The lin-11 LIM homeobox gene specifies olfactory and chemosensory neuron
RT fates in C. elegans.";
RL Development 128:3269-3281(2001).
RN [8]
RP FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE, AND MUTAGENESIS OF
RP GLY-340; ALA-349; ALA-350; ALA-353; ARG-356; ARG-372; 393-LYS-ARG-394 AND
RP GLU-403.
RX PubMed=14704165; DOI=10.1093/genetics/165.4.1779;
RA Colosimo M.E., Tran S., Sengupta P.;
RT "The divergent orphan nuclear receptor ODR-7 regulates olfactory neuron
RT gene expression via multiple mechanisms in Caenorhabditis elegans.";
RL Genetics 165:1779-1791(2003).
RN [9]
RP INDUCTION.
RX PubMed=19862965; DOI=10.1016/s1001-0742(08)62370-0;
RA Li Y., Ye H., Du M., Zhang Y., Ye B., Pu Y., Wang D.;
RT "Induction of chemotaxis to sodium chloride and diacetyl and thermotaxis
RT defects by microcystin-LR exposure in nematode Caenorhabditis elegans.";
RL J. Environ. Sci. 21:971-979(2009).
CC -!- FUNCTION: Required for the function of one pair of chemosensory neurons
CC called AWA neurons that are involved in chemotaxis to volatile
CC odorants. Acts in a pathway that specifies olfactory neuronal fate.
CC Regulates the transcription of olfactory signaling molecules such as
CC odr-10 that specify AWA neuron identity and function. Represses the
CC expression in AWA neurons of factors such as str-2 which specify AWC
CC neuron identity. {ECO:0000269|PubMed:10421632,
CC ECO:0000269|PubMed:11018015, ECO:0000269|PubMed:11546744,
CC ECO:0000269|PubMed:14704165, ECO:0000269|PubMed:8601313}.
CC -!- SUBUNIT: Heterodimer with a partner that confers DNA binding capacity
CC or a nuclear hormone receptor whose DNA binding it inhibits.
CC {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm, perinuclear region.
CC -!- TISSUE SPECIFICITY: Expressed predominantly in the AWA neurons.
CC {ECO:0000269|PubMed:10421632, ECO:0000269|PubMed:11018015,
CC ECO:0000269|PubMed:11546744, ECO:0000269|PubMed:14704165,
CC ECO:0000269|PubMed:8001144, ECO:0000269|PubMed:8601313}.
CC -!- DEVELOPMENTAL STAGE: May be expressed at all postembryonic stages.
CC {ECO:0000269|PubMed:8001144}.
CC -!- INDUCTION: Down-regulated by the cyanotoxin microcystin-LR.
CC {ECO:0000269|PubMed:19862965}.
CC -!- DISRUPTION PHENOTYPE: Worms are defective in chemotaxis to the volatile
CC odorants diacetyl and pyrazine and weakly defective in chemotaxis to
CC 2,4,5-trimethylthiazole, but respond normally to the odorants
CC benzaldehyde, butanone, and isoamyl alcohol.
CC {ECO:0000269|PubMed:14704165, ECO:0000269|PubMed:8001144}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR0
CC subfamily. {ECO:0000305}.
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DR EMBL; U16708; AAC46497.1; -; mRNA.
DR EMBL; FJ455633; ACQ44083.1; -; Genomic_DNA.
DR EMBL; FJ455634; ACQ44084.1; -; Genomic_DNA.
DR EMBL; FJ455635; ACQ44085.1; -; Genomic_DNA.
DR EMBL; FJ455636; ACQ44086.1; -; Genomic_DNA.
DR EMBL; FJ455637; ACQ44087.1; -; Genomic_DNA.
DR EMBL; FJ455638; ACQ44088.1; -; Genomic_DNA.
DR EMBL; FJ455639; ACQ44089.1; -; Genomic_DNA.
DR EMBL; FJ455640; ACQ44090.1; -; Genomic_DNA.
DR EMBL; FJ455641; ACQ44091.1; -; Genomic_DNA.
DR EMBL; FJ455642; ACQ44092.1; -; Genomic_DNA.
DR EMBL; FJ455643; ACQ44093.1; -; Genomic_DNA.
DR EMBL; FJ455644; ACQ44094.1; -; Genomic_DNA.
DR EMBL; Z68119; CAA92192.1; -; Genomic_DNA.
DR PIR; T24962; T24962.
DR RefSeq; NP_510089.1; NM_077688.3.
DR AlphaFoldDB; P41933; -.
DR SMR; P41933; -.
DR BioGRID; 46307; 6.
DR IntAct; P41933; 6.
DR STRING; 6239.T18D3.2; -.
DR PaxDb; P41933; -.
DR PRIDE; P41933; -.
DR EnsemblMetazoa; T18D3.2.1; T18D3.2.1; WBGene00003854.
DR GeneID; 181403; -.
DR KEGG; cel:CELE_T18D3.2; -.
DR UCSC; T18D3.2; c. elegans.
DR CTD; 181403; -.
DR WormBase; T18D3.2; CE03663; WBGene00003854; odr-7.
DR eggNOG; ENOG502S815; Eukaryota.
DR HOGENOM; CLU_614276_0_0_1; -.
DR InParanoid; P41933; -.
DR OMA; QVCLSTH; -.
DR OrthoDB; 1358786at2759; -.
DR PRO; PR:P41933; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00003854; Expressed in pharyngeal muscle cell (C elegans).
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:WormBase.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0022401; P:negative adaptation of signaling pathway; IMP:WormBase.
DR GO; GO:0050918; P:positive chemotaxis; IMP:WormBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:WormBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00399; ZnF_C4; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 1: Evidence at protein level;
KW Chemotaxis; Cytoplasm; DNA-binding; Metal-binding; Nucleus; Olfaction;
KW Receptor; Reference proteome; Repressor; Sensory transduction;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..457
FT /note="Nuclear hormone receptor family member odr-7"
FT /id="PRO_0000053747"
FT DNA_BIND 327..407
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 330..351
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 367..395
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 57..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 230..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 435..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 47
FT /note="E -> D (in strain: CB4857)"
FT /evidence="ECO:0000269|PubMed:19001295"
FT VARIANT 155
FT /note="S -> P (in strain: CB4855)"
FT /evidence="ECO:0000269|PubMed:19001295"
FT VARIANT 165
FT /note="T -> P (in strain: CB4855)"
FT /evidence="ECO:0000269|PubMed:19001295"
FT MUTAGEN 340
FT /note="G->E: In KY55; loss of chemotaxis to diacetyl."
FT /evidence="ECO:0000269|PubMed:14704165,
FT ECO:0000269|PubMed:8001144"
FT MUTAGEN 349
FT /note="A->E: Loss of autoregulation, loss of chemotaxis to
FT diacetyl and pyrazine."
FT /evidence="ECO:0000269|PubMed:14704165"
FT MUTAGEN 350
FT /note="A->V: In OY43; loss of autoregulation, loss of
FT chemotaxis to diacetyl and pyrazine."
FT /evidence="ECO:0000269|PubMed:14704165"
FT MUTAGEN 353
FT /note="A->V: No effect."
FT /evidence="ECO:0000269|PubMed:14704165"
FT MUTAGEN 356
FT /note="R->E: Loss of regulation of str-2 expression in AWA
FT and AWC neurons, loss of autoregulation, loss of chemotaxis
FT to diacetyl and pyrazine."
FT /evidence="ECO:0000269|PubMed:14704165"
FT MUTAGEN 372
FT /note="R->A: Loss of chemotaxis to diacetyl."
FT /evidence="ECO:0000269|PubMed:14704165"
FT MUTAGEN 393..394
FT /note="KR->AG: Loss of regulation of str-2 expression in
FT AWC neurons, loss of chemotaxis to diacetyl and pyrazine."
FT /evidence="ECO:0000269|PubMed:14704165"
FT MUTAGEN 403
FT /note="E->Q: Loss of regulation of str-2 expression in AWC
FT neurons."
FT /evidence="ECO:0000269|PubMed:14704165"
SQ SEQUENCE 457 AA; 51826 MW; 1BFF2CA41A72287C CRC64;
MIVPDTEGLL IYSYGLMYGS YCMACQMLIP HFQCIPGIFP NFRISTELIK TMTDKLEQPN
NNVPQQPWGP FPPAFGGRPS GEQTDGNPGE FDNDAAHQQT APFMTHFFPR IGLQFPDFTE
YQRFNGFQRN AFFPNPFGSQ FTGQAFAQSF PLHNSMTTMD GFNLTHAPHP FSTNTNSTKP
KDIENTVQST IKHSSENIQD KPPVLSVEYP VKYDSELKFD ANVDFTAVPK QESSDDSTLK
NLKKSDQQLQ QPQQFTFPPP LLAEKSFEQP RMREDVLPFH PQFYPAPLDM GTNFKQEMRT
PPIDGHIDYR KFDASGKRME FQPPGALHDC QVCLSTHANG LHFGARTCAA CAAFFRRTIS
DDKRYVCKRN QRCNNASRDG TGYRKICRSC RMKRCLEIGM LPENVQHKRN RRDSGSPPRK
TPFDTFFNGF YPSFQPSGSA AQPITVSSSE SPRHTTN
