ID   OE27_NPVOP              Reviewed;         297 AA.
AC   O10372;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Occlusion-derived virus envelope protein E27;
DE            Short=ODV-E27;
GN   ORFNames=ORF141;
OS   Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=262177;
OH   NCBI_TaxID=33414; Orgyia pseudotsugata (Douglas-fir tussock moth).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9126251; DOI=10.1006/viro.1997.8448;
RA   Ahrens C.H., Russell R.R., Funk C.J., Evans J., Harwood S., Rohrmann G.F.;
RT   "The sequence of the Orgyia pseudotsugata multinucleocapsid nuclear
RT   polyhedrosis virus genome.";
RL   Virology 229:381-399(1997).
CC   -!- FUNCTION: Acts as a cyclin-like protein and plays a role in the
CC       modulation of host cell cycle. May promote G2/S arrest by interacting
CC       with host mus209/PCNA, cdc2 and cdk6. The cell cycle arrest is
CC       characterized by an intact nuclear envelope, concomitant with sustained
CC       activity of host cdc2. However, viral DNA replication still occurs in
CC       the arrested cells (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with host mus209/PCNA, cdc2 and cdk6. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the baculoviridae E27 family. {ECO:0000305}.
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DR   EMBL; U75930; AAC59140.1; -; Genomic_DNA.
DR   RefSeq; NP_046297.1; NC_001875.2.
DR   GeneID; 912081; -.
DR   KEGG; vg:912081; -.
DR   Proteomes; UP000009248; Genome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0060153; P:modulation by virus of host cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR007978; Baculo_ODV-E27.
DR   Pfam; PF05314; Baculo_ODV-E27; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction; Membrane;
KW   Modulation of host cell cycle by viral cyclin-like protein;
KW   Modulation of host cell cycle by virus; Viral envelope protein; Virion.
FT   CHAIN           1..297
FT                   /note="Occlusion-derived virus envelope protein E27"
FT                   /id="PRO_0000132922"
SQ   SEQUENCE   297 AA;  34330 MW;  FB23F3C29988C032 CRC64;
     MKRVRCNKVR TVTEVKPNNA KIRKTYDLNE FDLKNLSSLE SFENTKVKLA LSKYMAMINT
     LEMTQPLLEV FRNRADTRQI VAVVQATMGF VHNRFNPLVT HFTNKMEFVT TETAETIIPG
     EPILFTENDG ALLCAIDRPS IVKMLSREFD LSVAAEPQTS NREVLVAKTL VSNKRKRRSS
     NDEGYEFIKR PRTFSEYNQC MDALSDFNVT EIETTQYLLL LLIVEHAYLH YYIFKNYGAL
     EYSKSLMDHS LFVNKLRSST NAKMHNLLLS KFRFTVEESD KTSSGTTSKF TVYNFNK