ID   A28_SHEVK               Reviewed;         140 AA.
AC   P16718;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Envelope protein A28 homolog;
DE   AltName: Full=Protein HM3;
GN   ORFNames=HM3;
OS   Sheeppox virus (strain KS-1) (SPPV) (Capripoxvirus (strain KS-1)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Capripoxvirus.
OX   NCBI_TaxID=10269;
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2795717; DOI=10.1128/jvi.63.11.4703-4708.1989;
RA   Gershon P.D., Ansell D.M., Black D.N.;
RT   "A comparison of the genome organization of capripoxvirus with that of the
RT   orthopoxviruses.";
RL   J. Virol. 63:4703-4708(1989).
CC   -!- FUNCTION: Envelope protein required for virus entry into host cell and
CC       for cell-cell fusion (syncytium formation). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass type
CC       II membrane protein {ECO:0000305}. Note=Component of the intracellular
CC       mature virion (IMV) membrane. {ECO:0000250}.
CC   -!- PTM: Contains two intramolecular disulfide bonds. They are created by
CC       the viral disulfide bond formation pathway, a poxvirus-specific pathway
CC       that operates on the cytoplasmic side of the MV membranes (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae A28 protein family.
CC       {ECO:0000305}.
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DR   EMBL; M30039; AAC32899.1; -; Genomic_DNA.
DR   PIR; C33325; WMVZM3.
DR   RefSeq; NP_659690.1; NC_004002.1.
DR   GeneID; 944593; -.
DR   KEGG; vg:944593; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0039663; P:membrane fusion involved in viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR007664; Poxvirus_A28.
DR   Pfam; PF04584; Pox_A28; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Fusion of virus membrane with host membrane; Late protein;
KW   Membrane; Signal-anchor; Transmembrane; Transmembrane helix;
KW   Viral envelope protein; Viral penetration into host cytoplasm; Virion;
KW   Virus entry into host cell.
FT   CHAIN           1..140
FT                   /note="Envelope protein A28 homolog"
FT                   /id="PRO_0000099287"
FT   TRANSMEM        1..21
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        22..140
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   140 AA;  16203 MW;  AB22777F3A99094A CRC64;
     MNAITIFFII LSTVAVCIII FQLYSIYLNY DNIKEFNSAH SAFEFSKSVN TLSLDRTIKD
     PNDDIYDPKQ KWRCVKLDND YVSVSMFGFK SNGSEIRKFK NLESCIDYTF SQSTHSDIKN
     PCILQNGIKS KECIFLKSMF