OEP37_ARATH
ID OEP37_ARATH Reviewed; 343 AA.
AC O80565; F4IT23; F4IT24; Q94AM0;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Outer envelope pore protein 37, chloroplastic;
DE AltName: Full=Chloroplastic outer envelope pore protein of 37 kDa;
DE Short=AtOEP37;
DE Flags: Precursor;
GN Name=OEP37; OrderedLocusNames=At2g43950; ORFNames=F6E13.8;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY.
RX PubMed=12649433; DOI=10.1110/ps.0237503;
RA Schleiff E., Eichacker L.A., Eckart K., Becker T., Mirus O., Stahl T.,
RA Soll J.;
RT "Prediction of the plant beta-barrel proteome: a case study of the
RT chloroplast outer envelope.";
RL Protein Sci. 12:748-759(2003).
RN [5]
RP FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND SUBCELLULAR
RP LOCATION.
RC STRAIN=cv. Columbia;
RX PubMed=16624824; DOI=10.1074/jbc.m600700200;
RA Goetze T.A., Philippar K., Ilkavets I., Soll J., Wagner R.;
RT "OEP37 is a new member of the chloroplast outer membrane ion channels.";
RL J. Biol. Chem. 281:17989-17998(2006).
CC -!- FUNCTION: Voltage-dependent peptide-sensitive high conductance
CC rectifying cation channel with a strong affinity for TIC32 that is
CC imported into the chloroplast. Conductance is pH-dependent decreasing
CC with decreasing pH values. {ECO:0000269|PubMed:16624824}.
CC -!- SUBUNIT: Forms an hourglass-shaped multimeric complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast outer membrane
CC {ECO:0000269|PubMed:16624824}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:16624824}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O80565-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O80565-2; Sequence=VSP_042323;
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed at low levels. Mostly
CC present in cotyledons, and accumulates in seedlings and embryos.
CC {ECO:0000269|PubMed:16624824}.
CC -!- DEVELOPMENTAL STAGE: During seed development, confined to green
CC cotyledons of mature embryos. In germinating seedlings, detected in
CC cotyledons and the root hair zone of the primary root. In older
CC seedlings, restricted to cotyledons. {ECO:0000269|PubMed:16624824}.
CC -!- SIMILARITY: Belongs to the plastid outer envelope porin OEP37 (TC
CC 1.B.47) family. {ECO:0000305}.
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DR EMBL; AC004005; AAC23403.2; -; Genomic_DNA.
DR EMBL; CP002685; AEC10352.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC10354.1; -; Genomic_DNA.
DR EMBL; AY045937; AAK76611.1; -; mRNA.
DR EMBL; AY079409; AAL85140.1; -; mRNA.
DR PIR; T00675; T00675.
DR RefSeq; NP_566003.1; NM_129957.4. [O80565-1]
DR RefSeq; NP_850405.2; NM_180074.3. [O80565-2]
DR AlphaFoldDB; O80565; -.
DR BioGRID; 4336; 1.
DR IntAct; O80565; 2.
DR STRING; 3702.AT2G43950.1; -.
DR TCDB; 1.B.47.1.2; the plastid outer envelope porin of 37 kda (oep37) family.
DR SwissPalm; O80565; -.
DR PaxDb; O80565; -.
DR PRIDE; O80565; -.
DR ProteomicsDB; 239017; -. [O80565-1]
DR EnsemblPlants; AT2G43950.1; AT2G43950.1; AT2G43950. [O80565-1]
DR EnsemblPlants; AT2G43950.2; AT2G43950.2; AT2G43950. [O80565-2]
DR GeneID; 819000; -.
DR Gramene; AT2G43950.1; AT2G43950.1; AT2G43950. [O80565-1]
DR Gramene; AT2G43950.2; AT2G43950.2; AT2G43950. [O80565-2]
DR KEGG; ath:AT2G43950; -.
DR Araport; AT2G43950; -.
DR TAIR; locus:2051844; AT2G43950.
DR eggNOG; ENOG502QQCE; Eukaryota.
DR HOGENOM; CLU_069482_0_0_1; -.
DR InParanoid; O80565; -.
DR OMA; DSNYWSA; -.
DR PhylomeDB; O80565; -.
DR PRO; PR:O80565; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O80565; baseline and differential.
DR Genevisible; O80565; AT.
DR GO; GO:0009507; C:chloroplast; IDA:TAIR.
DR GO; GO:0009941; C:chloroplast envelope; HDA:TAIR.
DR GO; GO:0009706; C:chloroplast inner membrane; IDA:TAIR.
DR GO; GO:0005829; C:cytosol; HDA:TAIR.
DR GO; GO:0031359; C:integral component of chloroplast outer membrane; IDA:UniProtKB.
DR GO; GO:0009536; C:plastid; HDA:TAIR.
DR GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR GO; GO:0005216; F:ion channel activity; IDA:TAIR.
DR GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR GO; GO:0006812; P:cation transport; IDA:TAIR.
DR InterPro; IPR038951; OEP37-like.
DR PANTHER; PTHR35484; PTHR35484; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Chloroplast; Ion transport; Membrane; Plastid;
KW Plastid outer membrane; Porin; Reference proteome; Transit peptide;
KW Transmembrane; Transmembrane beta strand; Transport.
FT TRANSIT 1..73
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN 74..343
FT /note="Outer envelope pore protein 37, chloroplastic"
FT /id="PRO_0000415711"
FT TOPO_DOM 74..76
FT /note="Cytoplasmic"
FT TRANSMEM 77..86
FT /note="Beta stranded; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 87..103
FT /note="Chloroplast intermembrane"
FT TRANSMEM 104..113
FT /note="Beta stranded; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..129
FT /note="Cytoplasmic"
FT TRANSMEM 130..137
FT /note="Beta stranded; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..154
FT /note="Chloroplast intermembrane"
FT TRANSMEM 155..164
FT /note="Beta stranded; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..169
FT /note="Cytoplasmic"
FT TRANSMEM 170..178
FT /note="Beta stranded; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 179..219
FT /note="Chloroplast intermembrane"
FT TRANSMEM 220..228
FT /note="Beta stranded; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 229..230
FT /note="Cytoplasmic"
FT TRANSMEM 231..240
FT /note="Beta stranded; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 241
FT /note="Chloroplast intermembrane"
FT TRANSMEM 242..250
FT /note="Beta stranded; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 251..257
FT /note="Cytoplasmic"
FT TRANSMEM 258..267
FT /note="Beta stranded; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 268..269
FT /note="Chloroplast intermembrane"
FT TRANSMEM 270..279
FT /note="Beta stranded; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 280..286
FT /note="Cytoplasmic"
FT TRANSMEM 287..296
FT /note="Beta stranded; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..316
FT /note="Chloroplast intermembrane"
FT TRANSMEM 317..326
FT /note="Beta stranded; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 327..343
FT /note="Cytoplasmic"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 302..343
FT /note="GDEAGKVKTTPMKMKVQFMLQVPQDDIKSSVLMFRVKKRWDI -> NHQPLV
FT FFSLFSHQRNLFTRLSPNPSHTSKML (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_042323"
SQ SEQUENCE 343 AA; 38835 MW; FB26B8C037EF7169 CRC64;
MADPSSQNPN LATPPPPSSP SPTHQIQSGT SELSPPSRPP CSTLSFLKTA NRPKLRVTSE
FDSDSLLFLN KVSCKLFDNL AKLKLSFQNN SQREISQPQV SFTSKHVSVL YDVEEKNTFI
KSTLDVHPRL QLRALHNVKA QQGEVAMEAN LTEPGYSLEL SSPVPIGYPR ATLKFPLGEI
SLQEKDEEEE EKQKRTLSVN GILKRQVMNG VCTALYTDEE LRLRYAYKDD ALSFIPSISL
PSNAASFAFK RRFSPSDKLS YWYNFDSNMW SAVYKRTYGK DYKLKAGYDS DVRLGWASLW
VGDEAGKVKT TPMKMKVQFM LQVPQDDIKS SVLMFRVKKR WDI
