ID   OFD1_DANRE              Reviewed;         901 AA.
AC   Q7SZK7;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Centriole and centriolar satellite protein ofd1 {ECO:0000305};
DE   AltName: Full=Oral-facial-digital syndrome 1 protein homolog;
GN   Name=ofd1; ORFNames=zgc:92562;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR
RP   LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=12782125; DOI=10.1016/s0888-7543(03)00091-0;
RA   Ferrante M.I., Barra A., Truong J.P., Banfi S., Disteche C.M., Franco B.;
RT   "Characterization of the OFD1/Ofd1 genes on the human and mouse sex
RT   chromosomes and exclusion of Ofd1 for the Xpl mouse mutant.";
RL   Genomics 81:560-569(2003).
CC   -!- FUNCTION: Component of the centrioles controlling mother and daughter
CC       centrioles length. Involved in the biogenesis of the cilium, a
CC       centriole-associated function. The cilium is a cell surface projection
CC       found in many vertebrate cells required to transduce signals important
CC       for development and tissue homeostasis. Plays an important role in
CC       development by regulating Wnt signaling and the specification of the
CC       left-right axis. {ECO:0000269|PubMed:12782125}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome, centriole {ECO:0000269|PubMed:12782125}. Cytoplasm,
CC       cytoskeleton, microtubule organizing center, centrosome, centriolar
CC       satellite {ECO:0000269|PubMed:12782125}. Cytoplasm, cytoskeleton,
CC       cilium basal body {ECO:0000269|PubMed:12782125}. Nucleus
CC       {ECO:0000250|UniProtKB:O75665}. Note=Localizes to centriole distal
CC       ends. {ECO:0000250|UniProtKB:O75665}.
CC   -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:12782125}.
CC   -!- DISRUPTION PHENOTYPE: Embryos display several alterations during
CC       development including perturbed intravesicular fluid flow in Kuppfer's
CC       vesicle, convergent extension defects and randomization of laterality
CC       of organs. {ECO:0000269|PubMed:12782125}.
CC   -!- SIMILARITY: Belongs to the OFD1 family. {ECO:0000305}.
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DR   EMBL; AJ534306; CAD58827.1; -; mRNA.
DR   AlphaFoldDB; Q7SZK7; -.
DR   SMR; Q7SZK7; -.
DR   STRING; 7955.ENSDARP00000000952; -.
DR   PaxDb; Q7SZK7; -.
DR   PRIDE; Q7SZK7; -.
DR   ZFIN; ZDB-GENE-030131-5427; ofd1.
DR   eggNOG; ENOG502QQR5; Eukaryota.
DR   InParanoid; Q7SZK7; -.
DR   PRO; PR:Q7SZK7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR   GO; GO:0005813; C:centrosome; IDA:ZFIN.
DR   GO; GO:0036064; C:ciliary basal body; IDA:ZFIN.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005576; C:extracellular region; IEA:GOC.
DR   GO; GO:0005634; C:nucleus; IDA:ZFIN.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   GO; GO:0060026; P:convergent extension; IMP:ZFIN.
DR   GO; GO:0060027; P:convergent extension involved in gastrulation; IMP:ZFIN.
DR   GO; GO:0061371; P:determination of heart left/right asymmetry; IMP:ZFIN.
DR   GO; GO:0060287; P:epithelial cilium movement involved in determination of left/right asymmetry; IMP:ZFIN.
DR   InterPro; IPR006594; LisH.
DR   Pfam; PF16045; LisH_2; 1.
DR   PROSITE; PS50896; LISH; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Coiled coil;
KW   Cytoplasm; Cytoskeleton; Nucleus; Reference proteome.
FT   CHAIN           1..901
FT                   /note="Centriole and centriolar satellite protein ofd1"
FT                   /id="PRO_0000394660"
FT   DOMAIN          65..97
FT                   /note="LisH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00126"
FT   REGION          541..563
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          585..697
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          709..901
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          164..512
FT                   /evidence="ECO:0000255"
FT   COILED          564..600
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        602..621
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        630..644
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        667..683
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        710..755
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        786..802
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        803..828
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        855..874
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        875..901
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   901 AA;  103862 MW;  C7B162DF6413490A CRC64;
     MSASKEESLS PDEMRQKLYQ TFKSRGLLDT LKTQLRNQLI QELQAPVRRG ESASRRSADH
     TDSVLVSACN SVVVDHLRSA GYEYTLSVFQ PECGLSKDKV LSSRDVLQIM KISPHMPLYK
     SLVSNIQSGQ SGFLKSLLME LTDHSVYRDC SDNSTQTTSI AAHKESLVEK MQLIDEEYEV
     LRHRGDRWAS VEAKLAEYRK EIQEQAQIEL NAKLQHFMDV EIAKVKQEEK ERSRKEILEL
     RRDMEKTYEL KSEALISREK NAIERLQKHQ EIEEKDIYAQ RQAVLREIES VRSREMELRQ
     RMEAFDKSCA LHEEKVKTME DLLRRRELSV KTMEDSFEQK LKSELLKYQL ELKEENMKRP
     EKLTENEERI RAEAARLQKE AAVVDAKTED YERKSSEVKQ LLMELESSRS QASLLKQQKE
     LLREQLENMR DYPELKKHTL ELQTRISLLK QQLEEKQQHN QRLTQELSAP SHEHLMLQAE
     LRRLEAEHKL EKEELETQKN VLHTQLQHEV QQCALLKTQL MECEERTKWM NTHTEELKLQ
     LQQTQQGPAL RGPKSRTVAP EHDSDMVISA LSRIRELEQE AERLEEAYRS HQQRALSAED
     PTLHRGSQNY SRATAAQQHR VISRSPIFAG RPIEEEHEEF SRTPSPAERL ASPPARRLSS
     TPQSASRSKR RADEEHDEHS LNPECVKGSS NTDRPALMFP ERLISPIPAE ELSSSISPNS
     PVMKSTTRHT QSPAKLQEIL LSSSSQESSP QPEKITLHDL TEPIQMVSAD QPCLLKDCEP
     ELQQDHPDVQ ISSSSSSSSS SQREEEQQRE THTLQQQPHE EQTQEQRDDA GGHVTSAASP
     TGGAEEANPL QRYMQMLMQD KQQEQSPNKE SSGSHEENLQ SESHEHSAGV ISHDEADDDF
     W