OFP12_ARATH
ID OFP12_ARATH Reviewed; 226 AA.
AC F4I8R6; Q9ZVZ6;
DT 09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Transcription repressor OFP12;
DE AltName: Full=Ovate family protein 12;
DE Short=AtOFP12;
GN Name=OFP12; OrderedLocusNames=At1g05420;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP INTERACTION WITH KNAT1; KNAT2; KNAT3 AND KNAT4.
RX PubMed=15781858; DOI=10.1073/pnas.0501181102;
RA Hackbusch J., Richter K., Muller J., Salamini F., Uhrig J.F.;
RT "A central role of Arabidopsis thaliana ovate family proteins in networking
RT and subcellular localization of 3-aa loop extension homeodomain proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:4908-4912(2005).
RN [4]
RP FUNCTION, TISSUE SPECIFICITY, AND GENE FAMILY.
RX PubMed=21886836; DOI=10.1371/journal.pone.0023896;
RA Wang S., Chang Y., Guo J., Zeng Q., Ellis B.E., Chen J.G.;
RT "Arabidopsis ovate family proteins, a novel transcriptional repressor
RT family, control multiple aspects of plant growth and development.";
RL PLoS ONE 6:E23896-E23896(2011).
CC -!- FUNCTION: Transcriptional repressor that regulates multiple aspects of
CC plant growth and development through the regulation of BEL1-LIKE (BLH)
CC and KNOX TALE (KNAT) homeodomain transcription factors.
CC {ECO:0000269|PubMed:21886836}.
CC -!- SUBUNIT: Interacts with KNAT1, KNAT2, KNAT3 and KNAT4.
CC {ECO:0000269|PubMed:15781858}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, shoots, stems, flower buds and
CC siliques. {ECO:0000269|PubMed:21886836}.
CC -!- MISCELLANEOUS: Plants over-expressing OFP12 have no visible phenotype.
CC {ECO:0000305|PubMed:21886836}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF79723.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC005106; AAF79723.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002684; AEE27838.1; -; Genomic_DNA.
DR PIR; A86189; A86189.
DR RefSeq; NP_001323411.1; NM_001331548.1.
DR RefSeq; NP_172033.1; NM_100421.2.
DR AlphaFoldDB; F4I8R6; -.
DR BioGRID; 22285; 8.
DR IntAct; F4I8R6; 7.
DR STRING; 3702.AT1G05420.1; -.
DR PaxDb; F4I8R6; -.
DR PRIDE; F4I8R6; -.
DR EnsemblPlants; AT1G05420.1; AT1G05420.1; AT1G05420.
DR GeneID; 837043; -.
DR Gramene; AT1G05420.1; AT1G05420.1; AT1G05420.
DR KEGG; ath:AT1G05420; -.
DR Araport; AT1G05420; -.
DR TAIR; locus:2201011; AT1G05420.
DR eggNOG; ENOG502S0CD; Eukaryota.
DR HOGENOM; CLU_069722_1_0_1; -.
DR InParanoid; F4I8R6; -.
DR OMA; KDFRFSM; -.
DR OrthoDB; 1531622at2759; -.
DR PRO; PR:F4I8R6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4I8R6; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:TAIR.
DR InterPro; IPR038933; Ovate.
DR InterPro; IPR006458; Ovate_C.
DR PANTHER; PTHR33057; PTHR33057; 1.
DR Pfam; PF04844; Ovate; 1.
DR TIGRFAMs; TIGR01568; A_thal_3678; 1.
DR PROSITE; PS51754; OVATE; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..226
FT /note="Transcription repressor OFP12"
FT /id="PRO_0000429681"
FT DOMAIN 152..217
FT /note="OVATE"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01090"
FT REGION 68..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 226 AA; 24968 MW; 4482E6FF1117472E CRC64;
MPRVMWKNFH LCFPSNLTKP SSSPSGATSD DPNRPSILLI NNFNLLYDDS SAAHRRLSKP
LIHDVEPSST FTASTSTAAN SSSSSASYDD SDNYGFAPDD DSPPPDLTAV LASRRFFFSS
PGCSNSITDS PDLRCRDNYD TATRLLTGGT AVKHYVQSPD PYNDFRRSMQ EMIDAVTNAG
DLRRYEFLHE LLLSYLSLNA ADTHKFIIRA FADILVSLLS DGHRIS
