OFP18_ARATH
ID OFP18_ARATH Reviewed; 282 AA.
AC Q9SVD5; Q8L8M7;
DT 09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 100.
DE RecName: Full=Transcription repressor OFP18;
DE AltName: Full=Ovate family protein 18;
DE Short=AtOFP18;
GN Name=OFP18; OrderedLocusNames=At3g52540; ORFNames=F22O6.80;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION, TISSUE SPECIFICITY, AND GENE FAMILY.
RX PubMed=21886836; DOI=10.1371/journal.pone.0023896;
RA Wang S., Chang Y., Guo J., Zeng Q., Ellis B.E., Chen J.G.;
RT "Arabidopsis ovate family proteins, a novel transcriptional repressor
RT family, control multiple aspects of plant growth and development.";
RL PLoS ONE 6:E23896-E23896(2011).
CC -!- FUNCTION: Transcriptional repressor that regulates multiple aspects of
CC plant growth and development through the regulation of BEL1-LIKE (BLH)
CC and KNOX TALE (KNAT) homeodomain transcription factors.
CC {ECO:0000269|PubMed:21886836}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in roots and shoots.
CC {ECO:0000269|PubMed:21886836}.
CC -!- MISCELLANEOUS: Plants over-expressing OFP18 show small rosette size,
CC late flowering, reduced fertilization and blunt-end siliques.
CC {ECO:0000305|PubMed:21886836}.
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DR EMBL; AL050300; CAB43415.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE78957.1; -; Genomic_DNA.
DR EMBL; AY088906; AAM67212.1; -; mRNA.
DR PIR; T08445; T08445.
DR RefSeq; NP_566967.1; NM_115114.4.
DR AlphaFoldDB; Q9SVD5; -.
DR BioGRID; 9738; 8.
DR IntAct; Q9SVD5; 8.
DR STRING; 3702.AT3G52540.1; -.
DR PaxDb; Q9SVD5; -.
DR PRIDE; Q9SVD5; -.
DR EnsemblPlants; AT3G52540.1; AT3G52540.1; AT3G52540.
DR GeneID; 824420; -.
DR Gramene; AT3G52540.1; AT3G52540.1; AT3G52540.
DR KEGG; ath:AT3G52540; -.
DR Araport; AT3G52540; -.
DR TAIR; locus:2079969; AT3G52540.
DR eggNOG; ENOG502RFQ4; Eukaryota.
DR HOGENOM; CLU_066339_1_0_1; -.
DR InParanoid; Q9SVD5; -.
DR OMA; WFLKVNV; -.
DR OrthoDB; 1441585at2759; -.
DR PRO; PR:Q9SVD5; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9SVD5; baseline and differential.
DR Genevisible; Q9SVD5; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:TAIR.
DR InterPro; IPR038933; Ovate.
DR InterPro; IPR006458; Ovate_C.
DR PANTHER; PTHR33057; PTHR33057; 1.
DR Pfam; PF04844; Ovate; 1.
DR TIGRFAMs; TIGR01568; A_thal_3678; 1.
DR PROSITE; PS51754; OVATE; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..282
FT /note="Transcription repressor OFP18"
FT /id="PRO_0000429687"
FT DOMAIN 139..199
FT /note="OVATE"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01090"
FT REGION 1..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..85
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 78
FT /note="S -> F (in Ref. 3; AAM67212)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 282 AA; 31519 MW; 257F2A585B702A85 CRC64;
MVRKMKLPFL NKNTSSSSFS SNSSSSSSSW PWPSSHQQNL KTISSKASFI VNKPKDVYEP
EPPPRSFSSS PSSSSYSSFS STSHAIENPP EIESIENVIK GLKSSKRLIF ERRGTSNSIL
EEATKRDDHE EEEDGLMLLS LESNDPYTDF KNSMEKMVEV HVLHHDWISL EKLLFWFLKV
NVKASHRYIF AAFVDLVLNL AVGPSKDVAG EPNSDVVVED SLSSSWPVSL YSSSDENSST
SVRFLPETSI GEKGRDVCCL SSLFELEEKI KDNIDPNDYV SS
