OFP2_ARATH
ID OFP2_ARATH Reviewed; 320 AA.
AC O04351;
DT 09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Transcription repressor OFP2;
DE AltName: Full=Ovate family protein 2;
DE Short=AtOFP2;
GN Name=OFP2; OrderedLocusNames=At2g30400; ORFNames=T9D9.21;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP INTERACTION WITH BLH1; BLH2; BLH3; BLH4; BLH6; BLH10; KNAT1; KNAT3; KNAT4;
RP KNAT5; KNAT6 AND KNAT7.
RX PubMed=15781858; DOI=10.1073/pnas.0501181102;
RA Hackbusch J., Richter K., Muller J., Salamini F., Uhrig J.F.;
RT "A central role of Arabidopsis thaliana ovate family proteins in networking
RT and subcellular localization of 3-aa loop extension homeodomain proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:4908-4912(2005).
RN [4]
RP FUNCTION, TISSUE SPECIFICITY, AND GENE FAMILY.
RX PubMed=21886836; DOI=10.1371/journal.pone.0023896;
RA Wang S., Chang Y., Guo J., Zeng Q., Ellis B.E., Chen J.G.;
RT "Arabidopsis ovate family proteins, a novel transcriptional repressor
RT family, control multiple aspects of plant growth and development.";
RL PLoS ONE 6:E23896-E23896(2011).
CC -!- FUNCTION: Transcriptional repressor that regulates multiple aspects of
CC plant growth and development through the regulation of BEL1-LIKE (BLH)
CC and KNOX TALE (KNAT) homeodomain transcription factors.
CC {ECO:0000269|PubMed:21886836}.
CC -!- SUBUNIT: Interacts with BLH1, BLH2, BLH3, BLH4, BLH6, BLH10, KNAT1,
CC KNAT3, KNAT4, KNAT5, KNAT6 and KNAT7. {ECO:0000269|PubMed:15781858}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, stems, flower buds and
CC siliques. {ECO:0000269|PubMed:21886836}.
CC -!- MISCELLANEOUS: Plants over-expressing OFP2 show kidney-shaped
CC cotyledons, round and curled leaves, small rosette size, late
CC flowering, reduced fertilization and round seeds.
CC {ECO:0000305|PubMed:21886836}.
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DR EMBL; AC002338; AAM14819.1; -; Genomic_DNA.
DR EMBL; U93215; AAB63094.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC08382.1; -; Genomic_DNA.
DR PIR; A84708; A84708.
DR RefSeq; NP_180599.1; NM_128593.2.
DR AlphaFoldDB; O04351; -.
DR BioGRID; 2940; 16.
DR IntAct; O04351; 16.
DR STRING; 3702.AT2G30400.1; -.
DR PaxDb; O04351; -.
DR PRIDE; O04351; -.
DR EnsemblPlants; AT2G30400.1; AT2G30400.1; AT2G30400.
DR GeneID; 817591; -.
DR Gramene; AT2G30400.1; AT2G30400.1; AT2G30400.
DR KEGG; ath:AT2G30400; -.
DR Araport; AT2G30400; -.
DR TAIR; locus:2064382; AT2G30400.
DR eggNOG; ENOG502RTS2; Eukaryota.
DR HOGENOM; CLU_036558_0_0_1; -.
DR InParanoid; O04351; -.
DR OMA; ECITEKK; -.
DR OrthoDB; 1209787at2759; -.
DR PhylomeDB; O04351; -.
DR PRO; PR:O04351; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O04351; baseline and differential.
DR Genevisible; O04351; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:TAIR.
DR InterPro; IPR025830; DNA_bnd_dom_ovate.
DR InterPro; IPR038933; Ovate.
DR InterPro; IPR006458; Ovate_C.
DR PANTHER; PTHR33057; PTHR33057; 1.
DR Pfam; PF13724; DNA_binding_2; 1.
DR Pfam; PF04844; Ovate; 1.
DR TIGRFAMs; TIGR01568; A_thal_3678; 1.
DR PROSITE; PS51754; OVATE; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..320
FT /note="Transcription repressor OFP2"
FT /id="PRO_0000429671"
FT DOMAIN 256..315
FT /note="OVATE"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01090"
FT REGION 25..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 178..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..87
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 320 AA; 36788 MW; F2870512D102E69E CRC64;
MGNYKFRISE MLPNAWFHKL KDVTKHSKPK NKASSSSSNT CSKKKPSSDS LPQHSYFSNS
LVANNPPHHN SPRNSLHTKK MSKRKTLYKP SLKPLTPPPL LVSASFNKSK INDQDSSYSL
FPAIETSPES FVYSFYEEDD DDEFVEFSNF KINTKNKAFT KQKVKVIDSV EKACTASKPI
KKPQKSHLSV KISRDEDDNE YKAEKKYQRQ VSSGRKPSAG INLKRVNSPR IQLSGTRRST
SRRSESKQDV LESFAVMKRS VDPKKDFRES MIEMIEENNI RASKDLEDLL ACYLTLNPKE
YHDLIIHVFE QIWLQLTKTK
